ORIGINAL ARTICLE Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 Carolyn T. Bramante, Jared D. Huling, Christopher J. Tignanelli, et al N Engl J Med 2022; 387:599-610DOI: 10.1056/NEJMoa2201662 Abstract BACKGROUND Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. METHODS In ...

Original Investigation  August 16, 2022 Association of COVID-19 vs Influenza With Risk of Arterial and Venous Thrombotic Events Among Hospitalized Patients Vincent Lo Re III, Sarah K. Dutcher, John G. Connolly, et al JAMA. 2022;328(7):637-651. doi:10.1001/jama.2022.13072 Key Points Question  Is the 90-day incidence of arterial thromboembolism and venous thromboembolism higher in patients hospitalized with COVID-19 vs in patients ...

ORIGINAL ARTICLEFREE PREVIEW A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries Daren K. Heyland, Lucy Wibbenmeyer, Jonathan A. Pollack, et al N Engl J Med 2022; 387:1001-1010DOI: 10.1056/NEJMoa2203364 Abstract BACKGROUND Glutamine is thought to have beneficial effects on the metabolic and stress response to severe injury. Clinical trials involving patients with burns and other critically ill patients have shown conflicting results re...

Original Investigation  August 9, 2022 Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis Sigrid Sandner, Björn Redfors, Dominick J. Angiolillo, et al JAMA. 2022;328(6):554-562. doi:10.1001/jama.2022.11966 Key Points Question  Is ticagrelor dual antiplatelet therapy (DAPT) for patients undergoing coronary artery bypass ...

Original Investigation  August 16, 2022 Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial Hui-Sheng Chen, Yu Cui, Xiao-Qiu Li, et al JAMA. 2022;328(7):627-636. doi:10.1001/jama.2022.13123 Key Points Question  Does remote ischemic conditioning, which involves repeated occlusion/release cycles on bilateral upper limb art...

ORIGINAL ARTICLEFREE PREVIEW Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis Enrique de-Madaria, James L. Buxbaum, Patrick Maisonneuve, et al N Engl J Med 2022; 387:989-1000DOI: 10.1056/NEJMoa2202884 Abstract BACKGROUND Early aggressive hydration is widely recommended for the management of acute pancreatitis, but evidence for this practice is limited. METHODS At 18 centers, we randomly assigned patients who presented with acute pan...

Original Investigation  August 9, 2022 Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial RESCUE BT Trial Investigators JAMA. 2022;328(6):543-553. doi:10.1001/jama.2022.12584 Key Points Question  Among patients with large vessel occlusion acute ischemic stroke, does administration of intravenous tirofiban befo...

Research Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study Isobel L Ward, Charlotte Bermingham, Daniel Ayoubkhani, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070695 (Published 02 August 2022)Cite this as: BMJ 2022;378:e070695 Abstract Objective To assess the risk of covid-19 death after infection with omicron BA.1 compared with delta (B.1.617.2). Design ...

Research Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose: OpenSAFELY cohort study using linked electronic health records Elsie M F Horne, William J Hulme, Ruth H Keogh, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071249 (Published 20 July 2022)Cite this as: BMJ 2022;378:e071249 Abstract Objective To estimate waning of covid-19 vaccine effectiveness over six months after second dose. Desi...

Original Investigation  September 6, 2022 Effect of Clinical Decision Support With Audit and Feedback on Prevention of Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Randomized Clinical Trial Matthew T. James, Bryan J. Har, Benjamin D. Tyrrell, et al JAMA. 2022;328(9):839-849. doi:10.1001/jama.2022.13382 Key Points Question  What is the effectiveness of clinical decision support, accompanied by audit and feedb...