Research Comparison of short term surgical outcomes of male and female gastrointestinal surgeons in Japan: retrospective cohort study Kae Okoshi, Hideki Endo, Sachiyo Nomura, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070568 (Published 28 September 2022)Cite this as: BMJ 2022;378:e070568 Abstract Objective To compare short term surgical outcomes between male and female gastrointestinal surgeons in Japan. Design Retrospective coho...

Research Letter  August 22, 2022 Compassionate Use of Tecovirimat for the Treatment of Monkeypox Infection Angel N. Desai, George R. Thompson III, Sonja M. Neumeister, et al JAMA. 2022;328(13):1348-1350. doi:10.1001/jama.2022.15336 Monkeypox is a zoonotic orthopoxvirus in the same genus as variola (the causative agent of smallpox).1 A recent global outbreak has led to more than 39 000 cases reported as of August 18, 2022.2 Monkeypox is typica...

Original Investigation  October 4, 2022 Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial The NO PAin Investigators JAMA. 2022;328(13):1326-1335. doi:10.1001/jama.2022.16844 Key Points Question  Does a multimodal opioid-sparing postoperative pain protocol reduce postoperative opioid consump...

Original Investigation  October 4, 2022 Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial Keith S. Kaye, Adam Belley, Philip Barth, et al JAMA. 2022;328(13):1304-1314. doi:10.1001/jama.2022.17034 Key Points Question  How does the efficacy of cefepime/enmetazobactam c...

ORIGINAL RESEARCH|ARTICLES IN PRESS Recall of awareness during paralysis among emergency department patients undergoing tracheal intubation Brian E. Driver, Matthew E. Prekker, Emily Wagner, et al Chest Published:September 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.08.2232 ABSTRACT Background Critically ill patients sometimes remember periods of neuromuscular blockade. Research Question What is the prevalence of recalled awareness during ...

ARTICLES|ONLINE FIRST Artificial intelligence-guided screening for atrial fibrillation using electrocardiogram during sinus rhythm: a prospective non-randomised interventional trial Peter A Noseworthy, Zachi I Attia, Emma M Behnken, et al  Lancet Published:September 27, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)01637-3 Summary Background Previous atrial fibrillation screening trials have highlighted the need for more targeted approaches. We did a...

ORIGINAL ARTICLE A Bivalent Omicron-Containing Booster Vaccine against Covid-19 Spyros Chalkias, Charles Harper, Keith Vrbicky, et al N Engl J Med September 16, 2022DOI: 10.1056/NEJMoa2208343 Abstract BACKGROUND The safety and immunogenicity of the bivalent omicron-containing mRNA-1273.214 booster vaccine are not known. METHODS In this ongoing, phase 2–3 study, we compared the 50-μg bivalent vaccine mRNA-1273.214 (25 μg each of ancestral Wuhan-Hu-1...

Original Investigation  September 27, 2022 Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19: The SOHO-COVID Randomized Clinical Trial Jean-Pierre Frat, Jean-Pierre Quenot, Julio Badie, et al JAMA. 2022;328(12):1212-1222. doi:10.1001/jama.2022.15613 Key Points Questions  In patients with respiratory failure due to COVID-19, does the use of high-fl...

CORRESPONDENCE IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination Lorenz Thurner, Christoph Kessel, Natalie Fadle, et al N Engl J Med September 21, 2022DOI: 10.1056/NEJMc2205667 TO THE EDITOR: Myocarditis associated with messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) predominantly affects male adolescents and young male adults (14 to <30 years of age) and typically occurs after receipt of the...

Original Investigation  September 20, 2022 Effect of Helmet Noninvasive Ventilation vs Usual Respiratory Support on Mortality Among Patients With Acute Hypoxemic Respiratory Failure Due to COVID-19: The HELMET-COVID Randomized Clinical Trial Yaseen M. Arabi, Sara Aldekhyl, Saad Al Qahtani, et al JAMA. 2022;328(11):1063-1072. doi:10.1001/jama.2022.15599 Key Points Question  What is the effect of noninvasive ventilation delivered b...