Original Research13 December 2022 Nirmatrelvir Plus Ritonavir for Early COVID-19 in a Large U.S. Health System: A Population-Based Cohort Study Scott Dryden-Peterson, Andy Kim, Arthur Y. Kim, et al Ann Intern Med https://doi.org/10.7326/M22-2141 Abstract Background: In the EPIC-HR (Evaluation of Protease Inhibition for Covid-19 in High-Risk Patients) trial, nirmatrelvir plus ritonavir led to an 89% reduction in hospitalization or death among unvaccinated...

Original Investigation  September 18, 2022 Routine Ultrasonography Guidance for Femoral Vascular Access for Cardiac ProceduresThe UNIVERSAL Randomized Clinical Trial Sanjit S. Jolly, Sulaiman AlRashidi, Marc-André d’Entremont, et al JAMA Cardiol. 2022;7(11):1110-1118. doi:10.1001/jamacardio.2022.3399 Key Points Question  Does routine ultrasonography guidance for femoral arterial access for cardiac procedures reduce bleeding or vascular com...

Original Investigation  September 19, 2022 Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial Fredrik Piehl, Ann Eriksson-Dufva, Anna Budzianowska, et al JAMA Neurol. 2022;79(11):1105-1112. doi:10.1001/jamaneurol.2022.2887 Key Points Question  Is a single infusion with rituximab associated with greater probability of having minimal disease manifestations at 4 months in recent...

Original Investigation  November 28, 2022 Autoimmune Encephalitis Misdiagnosis in Adults Eoin P. Flanagan, Michael D. Geschwind, A. Sebastian Lopez-Chiriboga, et al JAMA Neurol. Published online November 28, 2022. doi:10.1001/jamaneurol.2022.4251 Question  What diseases are misdiagnosed as autoimmune encephalitis and which factors contribute to misdiagnosis? Findings  In this case series of 107 outpatients misdiagnosed ...

Original Investigation  November 2, 2022 Electroacupuncture vs Sham Electroacupuncture in the Treatment of Postoperative Ileus After Laparoscopic Surgery for Colorectal Cancer: A Multicenter, Randomized Clinical Trial Yu Wang, Jing-Wen Yang, Shi-Yan Yan, et al JAMA Surg. Published online November 2, 2022. doi:10.1001/jamasurg.2022.5674 Key Points Question  In the current medical practice adopting the Enhanced Recovery After Surge...

RTICLES|ONLINE FIRST Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial Christopher C Butler, F D Richard Hobbs, Oghenekome A Gbinigie, et al Lancet AccessPublished:December 22, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02597-1 Summary Background The safety, effectiveness, and cost-effective...

Original Investigation  September 21, 2022 Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomized Clinical Trial Niloofar Dehghan, Aaron Nauth, Emil Schemitsch, et al JAMA Surg. 2022;157(11):983-990. doi:10.1001/jamasurg.2022.4299 Question  Does surgical treatment of unstable chest wall injuries improve ventilator-free days and outcomes compared to nonoperative treatment? Findings  In this randomi...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalImpact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trialBagshaw S.M. et al.OPEN ACCESS ~ OriginalModel-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trialEwoldt T.M.J. et al.Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study...

Original Investigation  November 30, 2022 Association Between Hemorrhage Control Interventions and Mortality in US Trauma Patients With Hemodynamically Unstable Pelvic Fractures Tanya Anand, Khaled El-Qawaqzeh, Adam Nelson, et al JAMA Surg. Published online November 30, 2022. doi:10.1001/jamasurg.2022.5772 Question  What is the current variation in nationwide practices for the management of pelvic fracture–related hemorrhage? Fin...

Research Letter  November 28, 2022 Analysis of Failure Rates for COVID-19 Entrance Screening at a US Academic Medical Center Scott C. Roberts, Ridwan N. Faruq, Anne K. Wilkinson, et al JAMA Intern Med. Published online November 28, 2022. doi:10.1001/jamainternmed.2022.5426 Many health care facilities use entrance screening to prevent individuals with acute COVID-19 from entering. In ambulatory settings, 1 study found failures (defined as an e...