Original Investigation  February 7, 2023 Association Between Drug Characteristics and Manufacturer Spending on Direct-to-Consumer Advertising Michael J. DiStefano, Jenny M. Markell, Caroline C. Doherty, et al JAMA. 2023;329(5):386-392. doi:10.1001/jama.2022.23968 Key Points Question  What drug characteristics are associated with larger proportions of promotional spending allocated to direct-to-consumer advertising? Findings&nb...

Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial Kazuma Nagata, Takeo Horie, Naohiko Chohnabayashi, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1326-1335 DOI: 10.1164/rccm.202201-0199OC Abstract Rationale: The long-term effects of using a high-flow nasal cannula for chronic hypercapnic respiratory failure caused by chronic obstructive pulmonary disease remain unclear. Object...

Original Investigation  November 23, 2022 Safety and Efficacy of Robotic vs Open Liver Resection for Hepatocellular Carcinoma Fabrizio Di Benedetto, Paolo Magistri, Stefano Di Sandro, et al JAMA Surg. Published online November 23, 2022. doi:10.1001/jamasurg.2022.5697 Key Points Question  Is the robotic approach a safe strategy for hepatocellular carcinoma (HCC) resection with good long-term outcomes? Findings  In thi...

ARTICLES|ONLINE FIRST Effectiveness and durability of BNT162b2 vaccine against hospital and emergency department admissions due to SARS-CoV-2 omicron sub-lineages BA.1 and BA.2 in a large health system in the USA: a test-negative, case-control study Sara Y Tartof, Jeff M Slezak, Laura Puzniak, et al Lancet Respir Med Published:October 07, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00354-X Summary Background The SARS-CoV-2 omicron (B.1.1.529 BA.1) ...

ARTICLES|ONLINE FIRST Transfusion practice in patients receiving VV ECMO (PROTECMO): a prospective, multicentre, observational study Gennaro Martucci, Matthieu Schmidt, Cara Agerstrand, et al. Lancet Respir Med Published:October 11, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00353-8 Summary Background In patients receiving venovenous (VV) extracorporeal membrane oxygenation (ECMO) packed red blood cell (PRBC) transfusion thresholds are usually hig...

ARTICLES|ONLINE FIRST Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis Alexandre Tran, Shannon M Fernando, Bram Rochwerg, et al. Lancet Respir Med Published: October 10, 2022 DOI: https://doi.org/10.1016/S2213-2600(22)00296-X Summary Background Venovenous extracorporeal membrane oxygenation (ECMO) can be considered for patients with ...

ARTICLES|ONLINE FIRST The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study Joanne G Wildenbeest, Marie-Noëlle Billard, Roy P Zuurbier, et al. Lancet Respir Med Published:November 10, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00414-3 Summary Background Respiratory syncytial virus (RSV) is a major cause of hospitalisation in infants. The burden of RSV infection in healthy term infants ha...

ARTICLES|ONLINE FIRST In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study Roberto Lorusso, Maria Elena De Piero, Silvia Mariani, et al. Lancet Respir Med Published:November 16, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00403-9 Summary Background Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with ...

ARTICLES|ONLINE FIRST Favipiravir in patients hospitalised with COVID-19 (PIONEER trial): a multicentre, open-label, phase 3, randomised controlled trial of early intervention versus standard care Pallav L Shah, Christopher M Orton, Beatriz Grinsztejn, et al. Lancet Respir Med Published:December 14, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00412-X Summary Background COVID-19 has overwhelmed health services globally. Oral antiviral therapies are ...

ARTICLES|ONLINE FIRST Comparative outcomes of extracorporeal membrane oxygenation for COVID-19 delivered in experienced European centres during successive SARS-CoV-2 variant outbreaks (ECMO-SURGES): an international, multicentre, retrospective cohort study Matthieu Schmidt, David Hajage, Micha Landoll, et al. Lancet Respir Med Published:January 11, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00438-6 Summary Background To inform future research and ...