Original Investigation  Critical Care Medicine Physician Variation in Early Sepsis Management Ithan D. Peltan, Danielle Groat, Jorie Butler, et al JAMA Netw Open 2026;9;(2):e2556945. doi:10.1001/jamanetworkopen.2025.56945 Key Points Question  Are sepsis treatment practice patterns characterized by faster antimicrobial initiation associated with increased overtreatment, and what are their mechanisms? Fi...

Article Health outcomes according to severity of acute kidney injury at ICU admission: a population-based cohort study Hundemer, G.L., Dumicho, A.Y., Knoll, G.A. et al. Intensive Care Med(2026). Published: 05 February 2026 https://doi.org/10.1007/s00134-026-08317-5 Abstract Purpose The presence and severity of acute kidney injury (AKI) upon ICU admission provides important short- and long-term prognostic information. Existing reports have been limited...

Articles Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial Joseph P Broderick, Andrew M Naidech, Jordan J Elm, et al Lancet Available online 4 February 2026 https://doi.org/10.1016/S0140-6736(26)00097-8 Summary Background Recombinant factor VIIa has been shown to slow bleeding in patients with intracerebral h...

Article The comparison of circuit lifespan between integration and separation approach in extracorporeal membrane oxygenation patients requiring continuous renal replacement therapy support: a randomized controlled trial (E-CRRT Trial) Tangjitaree, P., Thanapongsatorn, P., Sinjira, T. et al. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08302-y Abstract Background The estimated incidence of acute kidney injury requiring renal replacement ...

HUMANITIES: ORIGINAL RESEARCHVolume 169, Issue 2P486-495February 2026 Post-Intensive Care Syndrome Awareness and Communication: Surveys of ICU Providers and Patients Mark L. Rolfsen, Matthew F. Mart, Hannah Kieffer, et al Chest 2026; 169: 486-495 DOI: 10.1016/j.chest.2025.08.048 Abstract Background Survivors of critical illness often experience new or worsening impairments in various domains of health after discharge, collectively referred to as post-...

JOURNAL ARTICLE EDITOR'S CHOICE Retreatment With Nirmatrelvir/Ritonavir Following Return of COVID-19 Symptoms and SARS-CoV-2 Positivity Wuyan Zhang, Steven G Terra, Edward Alan Weinstein, et al Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e33–e40, https://doi.org/10.1093/cid/ciaf548 Abstract Background Rebound of coronavirus disease 2019 (COVID-19) is defined as return of symptoms and/or viral positivity af...

JOURNAL ARTICLE Comparing Generative Artificial Intelligence vs Experts for Detection of Catheter-Associated Urinary Tract Infection Shatha Alshanqeeti, Karen Coffey, Karrie Mcdermott, et al Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 148–150, https://doi.org/10.1093/cid/ciaf486 Abstract A retrospective cohort study compared generative artificial intelligence (GenAI) versus infection control expert for catheter-as...

Original Investigation  Association of VA Surgeons Delayed Diagnosis of Anastomotic Leak and Failure to Rescue After Colon Resection Samantha L. Savitch, Kiran H. Lagisetty, Pasithorn A. Suwanabol JAMA Surg Published Online: February 11, 2026 doi: 10.1001/jamasurg.2025.6551 Key Points Question  Is delay in detection of anastomotic leak after colon resection associated with failure to rescue? Fi...

Original Investigation  Targeted Oxygen for Initial Resuscitation of Preterm Infants: The TORPIDO 30/60 Randomized Clinical Trial Ju Lee Oei, Adrienne Kirby, Javeed Travadi, et al JAMA 2026;335;(6):523-530. doi:10.1001/jama.2025.23327 Key Points Question  Does initiating resuscitation of extremely preterm newborns with a higher level of fraction of inspired oxygen (Fio2; 0.6) reduce risk of death or brain in...

Research Reliability of urological telesurgery compared with local surgery: multicentre randomised controlled trial Ye Wang, Dan Xia, Wanhai Xu, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2024-083588 (Published 28 January 2026)Cite this as: BMJ 2026;392:e083588 Abstract Objective To investigate whether the reliability of telesurgery is non-inferior to that of standard local surgery in patients undergoing urological robotic operations. Desi...