ORIGINAL ARTICLE Health Consequences of Thymus Removal in Adults Kameron A. Kooshesh, Brody H. Foy, David B. Sykes, et al N Engl J Med 2023; 389:406-417DOI: 10.1056/NEJMoa2302892 Abstract BACKGROUND The function of the thymus in human adults is unclear, and routine removal of the thymus is performed in a variety of surgical procedures. We hypothesized that the adult thymus is needed to sustain immune competence and overall health. METHODS We evalua...

ORIGINAL ARTICLE Extracorporeal Life Support in Infarct-Related Cardiogenic Shock Holger Thiele, Uwe Zeymer, Ibrahim Akin, et al N Engl J Med August 26, 2023DOI: 10.1056/NEJMoa2307227 Abstract BACKGROUND Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack of evidence regarding its effect on mortality. METHODS In this multicenter trial, patients with acute myocardial infarction...

ARTICLES|ONLINE FIRST Mortality associated with third-generation cephalosporin resistance in Enterobacterales bloodstream infections at eight sub-Saharan African hospitals (MBIRA): a prospective cohort study Alexander M Aiken, Andrea M Rehman, Marlieke E A de Kraker, et al Lancet Infect Dis Published:July 13, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00233-5 Summary Background Bacteria of the order Enterobacterales are common pathogens causing bl...

ARTICLES| VOLUME 23, ISSUE 8, P945-955, AUGUST 2023Download Full Issue Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial Nathan J Brendish, Kate R Beard, Ahalya K Malachira, et al Lancet Infect Dis 2023; 8: 945-955 Published:April 25, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00066-X ...

Original Investigation  August 15, 2023 Door-in-Door-out Times for Interhospital Transfer of Patients With Stroke Brian Stamm, Regina Royan, Mihai Giurcanu, et al JAMA. 2023;330(7):636-649. doi:10.1001/jama.2023.12739 Key Points Question  What is the median door-in-door-out time for interhospital transfer of patients with stroke, and what patient and hospital-level factors are associated with door-in-door-out time? Findings&nb...

ARTICLES|ONLINE FIRST Ultra-low tidal volume ventilation for COVID-19-related ARDS in France (VT4COVID): a multicentre, open-label, parallel-group, randomised trial Jean-Christophe Richard, Nicolas Terzi, Hodane Yonis, et al Lancet Respir Med Published:July 12, 2023DOI:https://doi.org/10.1016/S2213-2600(23)00221-7 Summary Background COVID-19-related acute respiratory distress syndrome (ARDS) is associated with a high mortality rate and longer mechanical ...

Original Investigation  Less Is More July 3, 2023 Hospital Culture and Intensity of End-of-Life Care at 3 Academic Medical Centers Elizabeth Dzeng, Jason N. Batten, Daniel Dohan, et al JAMA Intern Med. Published online July 3, 2023. doi:10.1001/jamainternmed.2023.2450 Key Points Question  What is the role of hospital culture and institutional structures in the provision of potentially nonbeneficial, high-intensity life-sustain...

Original Investigation  July 25, 2023 Identifying Children Likely to Benefit From Antibiotics for Acute Sinusitis: A Randomized Clinical Trial Nader Shaikh, Alejandro Hoberman, Timothy R. Shope, et al JAMA. 2023;330(4):349-358. doi:10.1001/jama.2023.10854 Key Points Question  In children aged 2 to 11 years with acute sinusitis, does the efficacy of antibiotic treatment differ based on nasopharyn...

Research Associations between self-reported healthcare disruption due to covid-19 and avoidable hospital admission: evidence from seven linked longitudinal studies for England Mark A Green, Martin McKee, Olivia KL Hamilton, et al BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2023-075133 (Published 19 July 2023)Cite this as: BMJ 2023;382:e075133 Abstract Objectives To examine whether there is an association between people who experienced disrupted acce...

Research Evaluating trends in private equity ownership and impacts on health outcomes, costs, and quality: systematic review Alexander Borsa, Geronimo Bejarano, Moriah Ellen, et al BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2023-075244 (Published 19 July 2023)Cite this as: BMJ 2023;382:e075244 Abstract Objective To review the evidence on trends and impacts of private equity (PE) ownership of healthcare operators. Design Systematic review. ...