COVID-19: The Surviving Sepsis Campaign Guidelines The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing rapidly spreading illness, and COVID-19 has now affected thousands of people around the world. Clinicians are in urgent need of guidance to deal with this crisis. A panel of 36 experts from 12 countries proposed 53 questions, reviewed literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ...

JAMA Clinical Guidelines Synopsis March 26, 2020 Management of Critically Ill Adults With COVID-19 Jason T. Poston, Bhakti K. Patel, Andrew M. Davis JAMA. Published online March 26, 2020. doi:10.1001/jama.2020.4914 Guideline title Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults With COVID-19 Developer Surviving Sepsis Campaign (SSC) Release date March 23, 2020 Target population Critic...

Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU Both acute liver failure (ALF) and acute on chronic liver failure (ACLF) are associated with high morbidity and mortality. Even today, medical treatment of these two disorders has limited benefits and for those who fail to respond, the only viable treatment is a liver transplant. Both ALF and ACLF rarely occur in isolation and in most cases there is multiple organ involvement. As with many critical...

Practice | Rapid Recommendations Gastrointestinal bleeding prophylaxis for critically ill patients: a clinical practice guideline Zhikang Ye, Annika Reintam Blaser, Lyubov Lytvyn, et al BMJ 2020; 368:l6722 doi: https://doi.org/10.1136/bmj.l6722 Abstract Clinical question 临床问题 What is the role of gastrointestinal bleeding prophylaxis (stress ulcer prophylaxis) in critically ill patients? This guideline was prompted by the publication of a new large ra...

ICU Management & Practice, Volume 19 - Issue 3, 2019 New ESPEN Guidelines for Nutrition in the Critically Ill: Help, What Happened!? ESPEN guidelines for nutrition in critical illness have shifted from optimistic anticipative nutritional pharmacotherapy towards cautious and balanced metabolic support. This important new orientation in ICU nutrition management is a consequence of recent strong RCT-based evidence. Introduction Recently, the new ESPEN gu...

JAMA Clinical Guidelines Synopsis September 23, 2019 Prevention and Management of Venous Thromboembolism Jonathan D. Paul, Adam S. Cifu JAMA. Published online September 23, 2019. doi:10.1001/jama.2019.13853 Guideline title 指南题目 2018 Guidelines for Management of Venous Thromboembolism 2018静脉血栓栓塞治疗指南 Developers 制定者 American Society of Hematology (ASH) and McMaster University GRADE Centre 美国血液病学会(ASH)及McM...

Viewpoint July 19, 2019 Evidence vs Consensus in Clinical Practice Guidelines Benjamin Djulbegovic, Gordon Guyatt JAMA. 2019;322(8):725-726. doi:10.1001/jama.2019.9751 Clinical practice guidelines have become increasingly prominent in clinical medicine over the last 4 decades, and represent one of the most important tools for potentially improving clinical decision-making and, in turn, potentially improving patients’ outcomes.1 Historically, many organ...

Editorial August 27, 2019 Reporting and Interpretation of Randomized Clinical Trials Howard Bauchner, Robert M. Golub, Phil B. Fontanarosa JAMA. 2019;322(8):732-735. doi:10.1001/jama.2019.12056 High-quality randomized clinical trials (RCTs) occupy the highest position on the evidence pyramid, either as stand-alone studies or as part of meta-analyses. However, the interpretation of an RCT is often complicated and involves an understanding of the ...

JAMA Clinical Guidelines Synopsis July 18, 2019 Management of Patients With Acute Ischemic Stroke James R. Brorson, Adam S. Cifu JAMA. Published online July 18, 2019. doi:10.1001/jama.2019.10436 Guideline title 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Release date January 24, 2018 Prior version 2013 Developer American Heart Association (AHA)/American Stroke Association (ASA) Funding ...

JAMA Network Clinical Guideline Synopsis April 17, 2019 The Society of Vascular Surgery Practice Guidelines on the Care of Patients With Abdominal Aortic Aneurysms Michol A. Cooper, Gilbert R. Upchurch Jr JAMA Surg. Published online April 17, 2019. doi:10.1001/jamasurg.2019.0566 Guideline title: The Society for Vascular Surgery Practice Guidelines on the Care of Patients with an Abdominal Aortic Aneurysm 指南标题：血管外科学会腹主动脉瘤患者诊...