Reducing Diagnostic Errors in Critical Illness  In ICU Fri, 31 Oct 2025 Accurate diagnosis underpins safe and effective critical care, yet the diagnostic process in acute illness is inherently vulnerable. Time pressure, evolving physiology and limited patient history often converge when illness is most severe. Critical illness is also encountered beyond intensive care units (ICUs) and in some cases follows earlier diagnostic missteps that escalate...

Optimal Timing of Anticoagulation After Ischaemic Stroke and Atrial Fibrillation In ICU Wed, 25 Jun 2025 Atrial fibrillation (AF) accounts for about 20–30% of ischaemic strokes. Direct oral anticoagulants (DOACs) are very effective for long-term secondary prevention of ischaemic stroke in AF patients, reducing the risk of intracranial haemorrhage by about half compared to vitamin K antagonists. However, the best timing to start anticoagulation after an...

Viewpoint  AI in Medicine Artificial Intelligence Is Not the End of the Physician Canio Martinelli, Vincenzo Carnevale, Alfredo Ercoli, et al JAMA Published Online: April 29, 2026 doi: 10.1001/jama.2026.4356 No one predicted that artificial intelligence (AI) would first surpass physicians on empathy—diagnostic accuracy, perhaps; imaging interpretation, certainly. Empathy was supposed to be the last refuge...

#LIVES2025: Proactive vs Reactive Treatment of Hypotension During Surgery  In ICU Tue, 28 Oct 2025 Intraoperative hypotension affects over 75% of surgical patients and is linked to serious complications, including myocardial ischaemia, kidney failure, and death. Despite this prevalence, uncertainty remains about optimal blood pressure management during surgery.  The PRETREAT (Proactive vs Reactive Treatment of Hypo...

EDITORIAL Same Pill, Different Impact — Reassessing the Efficacy of Nirmatrelvir–Ritonavir H. Clifford Lane, Anthony S. Fauci N Engl J Med 2026;394:1649-1650 DOI: 10.1056/NEJMe2603127 The first cases of Covid-19 were reported at the end of 2019, and from January 20, 2020, to May 5, 2023, Covid-19 was considered to be a public health emergency of international concern. The total number of cases worldwide exceeded 1 million by early April 2020. In the United ...

Sepsis Onset Timing Linked to Mortality and Hospital Burden In Sepsis Tue, 10 Mar 2026 Sepsis remains a major cause of hospital mortality and prolonged admission, placing sustained pressure on clinical teams and hospital resources. The timing of sepsis onset during hospitalisation influences both detection and outcomes. Community-onset sepsis (COS), identified early in admission, and hospital-onset sepsis (HOS), developing later in a hospital stay, ref...

Invited Commentary  To Tube or Not to Tube—A Case for Early Enteral Nutrition Yuqi Zhang, Krista Haines, Suresh Agarwal JAMA Surg Published Online: April 22, 2026 doi: 10.1001/jamasurg.2026.1058 The early introduction of enteral feeding after surgery is well recognized as a cornerstone of Enhanced Recovery After Surgery (ERAS) protocols, consistently shown to reduce postoperative infections and mortality across multiple surgical domains. Although prior...

Editorial  New Pathways to Treat Staphylococcus aureus Bacteremia: Connecting the DOTS Erin K. McCreary, Preeti N. Malani JAMA 2025;334;(10):861-863. doi:10.1001/jama.2025.13717 Staphylococcus aureus bacteremia is a leading cause of infection-related death worldwide.1 Roughly 30% of patients who develop S aureus bacteremia will die within a year of index culture, yet relatively few randomized clinical trials have evaluated optimal antibiotic therapy.2 Con...

Alarm Fatigue Linked to Compassion Fatigue in Surgical ICUs  In ICU Tue, 14 Oct 2025 Intensive care units rely on dense constellations of monitors, ventilators and infusion devices that generate frequent alarms to protect patients. Persistent exposure to these sounds can desensitise clinicians and reduce responsiveness, a phenomenon described as alarm fatigue. In parallel, sustained emotional demands and exposure to suffering can erode the capacit...

Invited Commentary  Fecal Microbiota Transplant for Multidrug Resistance—No Benefit Without Disruption? Brendan J. Kelly, Michael H. Woodworth, Jennie H. Kwon JAMA Intern Med Published Online: April 20, 2026 doi: 10.1001/jamainternmed.2026.0668 Fecal microbiota transplant (FMT) has transformed the medical treatment of recurrent Clostridium difficile infection (R-CDI). An explosion of randomized clinical trials during the 2010s demonstrated the effectiv...