Editorial  Moving the Field Forward to Safely Do Less With Febrile Neonates Justin B. Searns, Sean T. O’Leary JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.23133 Newborns with suspected infections are a common source of anxiety for pediatricians.1,2 As the adage goes, “never trust a newborn,” and for good reason. Young infants are immunologically vulnerable and at risk for rapid progression of bacterial infections during their postnata...

Federated LLMs Advance Adverse Drug Reaction Prediction  In ICU Sat, 13 Sep 2025 Adverse drug reactions remain a persistent threat to patient safety, ranging from mild discomfort to life-threatening events. Surveillance data underlines the scale of the problem, with large volumes of serious events reported and substantial mortality recorded alongside the growing complexity of modern pharmacotherapy. At the same time, the most informative clinical ...

ABCDEF-MT: Music Therapy and ICU Liberation In ICU Thu, 24 Jul 2025 ICU Management & Practice, Volume 25 - Issue 3, 2025 Music therapy’s (MT) integration into the ICU liberation bundle is underexplored. We highlight existing literature, present vignettes illustrating MT in action, and offer recommendations to optimise ICU MT across the lifespan.  Introduction The Intensive Care Unit (ICU) Liberation Bundle (A-F) is a comprehensive se...

Association Between Ventilator-Associated Events and Mortality In ICU Wed, 10 Sep 2025 In 2013, the Centers for Disease Control and Prevention (CDC)/National Healthcare Safety Network (NHSN) introduced ventilator-associated events (VAEs) as a surveillance-based quality indicator for monitoring respiratory complications in mechanically ventilated patients. VAEs are defined by sustained increases in PEEP or FiO₂, regardless of underlying pathology, ...

Managing Radiation Exposure in ICU Imaging  In ICU Tue, 9 Sep 2025 Imaging is integral to intensive care, where frequent X-rays, fluoroscopy, CT and nuclear medicine guide day-to-day decisions for critically ill patients. Repeated examinations during prolonged admissions can drive cumulative effective dose to levels that warrant careful management, with CT the dominant contributor. Safe delivery relies on robust justification, disciplined optimisa...

Peripheral Vasopressor Use for Sepsis-Induced Hypotension In Sepsis Wed, 10 Sep 2025 Vasopressors are standard therapy for sepsis-induced hypotension and shock, traditionally given via central venous catheters (CVCs) due to concerns about tissue injury from peripheral intravenous catheter (PIV) extravasation. Recent studies, however, suggest that peripheral vasopressors are safe, with low extravasation rates and minimal tissue injury, while offering ad...

Plasma Proteomics to Identify Molecular Subtypes in Sepsis In Sepsis Thu, 4 Sep 2025 Sepsis remains a leading cause of ICU mortality, with therapeutic progress limited to infection control and supportive care, as molecularly targeted treatments have failed in clinical trials due to the syndrome’s heterogeneity. Personalised medicine requires accurate biomarkers and mechanistic insights, and mass spectrometry–based plasma proteomics offers a promising a...

Sepsis Phenotyping and Differential Response to Fluid Resuscitation In Sepsis Thu, 4 Sep 2025 Sepsis is a life-threatening, dysregulated immune response often leading to hypotension and multisystem organ dysfunction, with acute kidney injury (AKI) being the most common organ failure in critically ill patients. Traditional broad therapies for sepsis have largely failed due to the heterogeneity of the syndrome. Recent approaches focus on identifying biol...

Extracorporeal CPR for Refractory Cardiac Arrest In ICU Thu, 4 Sep 2025 Sudden cardiac arrest is a major global cause of death, with around 640,000 cases annually in the USA (350,000 out-of-hospital, 290,000 in-hospital). Survival remains low, typically under 10% for OHCA and 15–34% for IHCA, varying widely across countries. Extracorporeal cardiopulmonary resuscitation (ECPR), which uses venoarterial ECMO during refractory cardiac arrest, may restor...

Editorial  The Importance of Real-World Evidence to Inform RSV Vaccine Guidance Anna Hung, Lona Mody JAMA Intern Med Published Online: November 24, 2025 doi: 10.1001/jamainternmed.2025.6364 Respiratory syncytial virus (RSV) is associated with increased risks of hospitalization and death in older adults with chronic conditions. To reduce risks in this population, 3 RSV vaccines are approved in adults 60 years and older. In June ...