Invited Commentary  From Balanced Blood Products to Personalized Medicine in Acute Resuscitation of Trauma Patients Taylor E. Wallen, John B. Holcomb JAMA Surg Published Online: March 11, 2026 doi: 10.1001/jamasurg.2026.0195 Resuscitation of patients experiencing hemorrhagic shock has changed tremendously over the last 30 years, moving from crystalloid and red blood cells to balanced components, and now with whole blood (WB) administration gaining favo...

Weaning from VV-ECMO: Data from ESICM-Endorsed WEAN-ECMO Survey In ICU Thu, 15 Jan 2026 The use of venovenous extracorporeal membrane oxygenation (VV ECMO) for severe acute respiratory distress syndrome (ARDS) has risen substantially, and current guidelines recommend VV ECMO in selected patients to maintain adequate gas exchange while limiting ventilator-induced lung injury. Despite this, several critical components of ECMO management remain poorly sta...

Invited Commentary  Pediatrics Respiratory Management of Neonatal Acute Respiratory Distress Syndrome Lucy Loft, David G. Tingay JAMA Netw Open 2026;9;(3):e260220. doi:10.1001/jamanetworkopen.2026.0220 High frequency oscillatory ventilation (HFOV) has been used to treat respiratory failure in neonates since the early 1990s.1 HFOV supports gas exchange by delivering very low tidal volumes at fast rates (>2 Hz). Theoretically, these characteristics of HF...

Antibiotic De-Escalation in Patients Hospitalised With Community-Onset Sepsis Sepsis is a critical medical emergency that requires prompt treatment with broad-spectrum antibiotics (BSAs) to cover potential multidrug-resistant organisms (MDROs). While early empiric BSA therapy has been associated with reduced mortality in high-risk patients and is recommended by the 2021 Surviving Sepsis Campaign Guidelines, prolonged exposure to these agents carries significant ris...

Invited Commentary  Cardiology Preventing ARDS, Not Treating It—Lessons From Sivelestat After Cardiopulmonary Bypass Warren L. Lee, Arthur S. Slutsky JAMA Netw Open 2026;9;(3):e261201. doi:10.1001/jamanetworkopen.2026.1201 Pan and colleagues1 report the findings of a large, blinded, placebo-controlled single-center randomized clinical trial of sivelestat for the prevention of acute respiratory distress syndrome (ARDS) among pat...

Blood Biomarkers for Prediction of Outcome After Cardiac Arrest A study published in The Lancet Respiratory Medicine has identified neurofilament light (NFL) as the most accurate blood biomarker for predicting long-term neurological outcomes in patients who remain unconscious following cardiac arrest. This research, conducted within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial, represents the largest prospective int...

ANDROMEDA-SHOCK 1 to ANDROMEDA-SHOCK 2: Capillary Refill Time & Personalised Haemodynamic Management In ICU Wed, 3 Dec 2025 ICU Management & Practice, Volume 25 - Issue 5, 2025 From ANDROMEDA-SHOCK 1 to ANDROMEDA-SHOCK 2, capillary refill time evolved from a bedside sign to a personalised, physiology-based resuscitation target with direct implications for clinical practice and ICU organisation. Introduction The evolution of haemodynamic re...

Rethinking Delirium in Critical Care In ICU Tue, 14 Oct 2025 ICU Management & Practice, Volume 25 - Issue 4, 2025 Delirium is a common but under-recognised ICU complication with short and long term cognitive, psychological, and functional consequences. It urges for a cultural change in critical care using routine screening, multidisciplinary prevention, and patient and family centred interventions to prioritise mental recovery alongside physical sur...

Respiratory Mechanics and Effort During SBTs to Predict Extubation Failure In ICU Thu, 11 Dec 2025 A study recently published in the American Journal of Respiratory and Critical Care Medicine investigated whether noninvasive monitoring of respiratory mechanics during spontaneous breathing trials (SBTs) could predict extubation failure in high-risk patients. The research was conducted across five general intensive care units in Italy between September 2022 ...

Human-Centred AI in Critical Care  In ICU Thu, 11 Dec 2025 A recent review advocates for a fundamental shift in how artificial intelligence is integrated into intensive care units, moving away from a narrow focus on model development towards comprehensive human-centred AI system design. The discussion is based on the World Health Organization’s 2021 ethical framework, which establishes six core principles for AI in healthcare: protecting human aut...