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Editorial May 5, 2022 Strategic Opportunities to Improve Stroke Systems of Care Kori S. Zachrison, Lee H. Schwamm JAMA. 2022;327(18):1765-1767. doi:10.1001/jama.2022.3820 Restoring reperfusion to the brain as quickly as possible during acute ischemic stroke is important to reduce long-term disability and optimize clinical outcomes for patients, although hospital and resource availability are frequently not well matched with patient location. Accordingly, ...
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Editorial March 22, 2022 Thromboinflammation and Antithrombotics in COVID-19: Accumulating Evidence and Current Status Jean M. Connors, Paul M Ridker JAMA. Published online March 22, 2022. doi:10.1001/jama.2022.2361 Thrombotic complications of SARS-CoV-2 infection were recognized early in the pandemic, when infected patients often presented with abnormal coagulation findings and acute macrovascular obstruction, and evidence of pulmonary microvas...
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News News Analysis Covid-19: Stockpiling antivirals risks repeating Tamiflu mistakes, experts warn Gareth Iacobucci BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o1053 (Published 27 April 2022)Cite this as: BMJ 2022;377:o1053 The UK government has made a huge investment in antivirals to fight covid, but some experts are concerned the waste and overspending of the 2000s will recur. Gareth Iacobucci reports The government’s Antivirals Taskforc...
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ICU Management & Practice, Volume 22 - Issue 2, 2022 Gastric Residual Volume – Monitoring and Management An overview of critical care guidelines for enteral nutrition (EN) and the use of gastric residual volume (GRV) management and monitoring as an essential component of EN patient care to help prevent complications. Malnutrition in Critically Ill and the Use of Enteral or Parenteral Nutrition Disease-related malnutrition is a common problem amon...
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ICU Management & Practice, Volume 22 - Issue 2, 2022 Septic Shock and Vasopressor Initiation: Why Earlier is Better An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock for reversing hypotension by increasing systemic vascular resistance and improving organ perfusion. The Surviving Sepsis Ca...
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electronic Poor Outcome Screening (ePOS) Score The number of elderly and multimorbid patients admitted to the ICU continues to increase. These patients are at a high risk of dying and are likely to suffer from poor long-term outcomes such as functional and cognitive impairment, psychological distress and 6-month mortality. In addition, these patients have complex palliative care needs and could benefit from specialised palliative care consultation, which could redu...
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Editorials Acute hepatitis of unknown origin in children Muge Cevik, Angela L Rasmussen, Isaac I Bogoch, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o1197 (Published 17 May 2022)Cite this as: BMJ 2022;377:o1197 Many leads but few clear answers Recent reports of severe acute hepatitis of unknown aetiology in previously healthy children across multiple countries have resulted in health alerts and a race to identify the underlying cause. By 11 May,...
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COMMENT|ONLINE FIRST When and which patients should receive remdesivir? Carolina Garcia-Vidal, Maurizio Sanguinetti Lancet Published: May 02, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00789-9 Despite 2 years having passed since the start of the COVID-19 pandemic, there is still intense debate about the best therapeutic strategy for patients with COVID-19. Multiple randomised studies have evaluated the efficacy of different antiviral,1, 2 anti-inflammat...
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Awake Prone Positioning for Non-Intubated COVID-19 Patients Prone positioning can improve oxygenation and mortality for intubated patients with moderate to severe acute respiratory distress syndrome (ARDS). Prone positioning of non-intubated patients called awake prone positioning has been used for non-intubated patients with COVID-19 related acute hypoxaemic respiratory failure. It has been proven to improve oxygenation and potentially avoid intubation. Multiple s...
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Findings from the COVID-VENT Trial Many patients with COVID-19-associated acute respiratory failure fulfil the criteria of acute respiratory distress syndrome (ARDS) and require invasive mechanical ventilation. Therefore, it is important to understand the features of gas exchange abnormalities, respiratory mechanics and lung recruitability in these patients to provide an appropriate adjustment of positive end-expiratory pressure (PEEP), the tidal volume (VT) and th...
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