SESAR Trial: Inhaled Sedation in Acute Respiratory Distress Syndrome In ICU Tue, 18 Mar 2025 Acute respiratory distress syndrome (ARDS) is common in ICU patients and has high mortality rates (35%-46%). Mechanical ventilation is essential for ARDS management and often requires sedation, though the optimal sedative choice remains unclear. Guidelines suggest light sedation with nonbenzodiazepine sedatives like propofol or dexmedetomidine, but specific rec...

EDITORIAL Baloxavir Treatment to Reduce Influenza Virus Transmission Timothy M. Uyeki, Vivien G. Dugan, Demetre C. Daskalakis N Engl J Med 2025;392:1652-1654 Antiviral treatment of influenza is recommended as soon as possible for hospitalized patients and for outpatients who are at increased risk for influenza-related complications.1,2 The Food and Drug Administration–approved oral antiviral agent oseltamivir is the most widely used antiviral medication f...

Anaesthesia Workforce Shortage: Reasons and Potential Solutions In ICU Mon, 10 Mar 2025 ICU Management & Practice, Volume 25 - Issue 1, 2025 PRINT OPTIMISED SCREEN OPTIMISED The shortage of anaesthetists poses significant challenges in healthcare. Potential short- and long-term solutions, oriented to ensure adequate patient care and safety are the topic of this article. It is becoming increasingly challenging for the directors of anaes...

Editorial  March 3, 2025 Protein S Genomics and Proteomics Refine Thrombosis Risk Margaret V. Ragni JAMA. 2025;333(16):1401-1402. doi:10.1001/jama.2025.1883 Protein S is a vitamin K–dependent protein named after Seattle, where it was isolated and characterized. Subsequently recognized as a multifunctional enzyme that plays a critical role in the regulation of coagulation, protein S limits excessive clot formation through its action on clot initiation a...

The Value of Viewing Burnout as a Relationship Crisis In ICU Mon, 10 Mar 2025 ICU Management & Practice, Volume 25 - Issue 1, 2025 Understanding burnout in the ICU setting requires a nuanced approach that goes beyond recognising its symptoms. It demands that leaders address the structural and environmental factors that contribute to chronic stress, in addition to interventions that support resilience and well-being. The intensive care enviro...

Net Albumin Leakage in Patients With Suspected Sepsis In Sepsis Wed, 12 Mar 2025 Sepsis is a major cause of mortality worldwide, with intravenous crystalloid infusion being the first-line treatment to maintain organ perfusion. However, fluid overload is associated with poor outcomes, and restrictive fluid therapy has not shown benefits. Albumin, due to its molecular properties, may help retain fluid intravascularly, but its volume-sparing effect in sep...

Invited Commentary  April 10, 2025 Cutting the Antibiotic Spectrum for Low-Risk Abdominal Infection Joshua B. Brown JAMA Surg. Published online April 10, 2025. doi:10.1001/jamasurg.2025.1107 The rise of antibiotic stewardship efforts has seen success, but evidence is heterogeneous across different conditions. Intra-abdominal infection is one such area where there is a relative paucity of data for effective stewardship interventions. Given the...

Editorial  Patient, Treatment, Outcome, Large Simple Trials of Common Therapies Kevin P. Seitz, Jonathan D. Casey, Matthew W. Semler JAMA Published Online: June 12, 2025 doi: 10.1001/jama.2025.9657 Each year, as many as 20 million critically ill adults receive mechanical ventilation worldwide, and approximately 1 in 3 die before hospital discharge.1-3 For every patient receiving mechanical ventilation, the fraction of inspired oxygen (Fio2) must b...

Benefit From Adjuvant Therapy With Corticosteroids in Community-Acquired Pneumonia In ICU Wed, 12 Mar 2025 Community-acquired pneumonia (CAP) is a leading cause of hospitalisation with high mortality. It can be caused by various pathogens, including viruses, bacteria, and fungi, complicating treatment. Adjuvant corticosteroid treatment may help reduce excessive inflammation, which is linked to higher mortality.  While RCTs and a meta-analysis s...

Update: Guidelines on Adult Critical Care Ultrasonography In ICU Tue, 4 Mar 2025 Critical care ultrasonography (CCUS) is a point-of-care tool used by clinicians to aid diagnosis, manage care, and guide procedures for critically ill patients. It has become widely adopted in critical care, but its impact on patient outcomes remains uncertain. This executive summary updates previous CCUS guidelines by comparing clinical outcomes with and without CCUS i...