Risk Factors and Outcome Associated With Fungal Infections in Patients With Severe Burn Injury: 10-year Retrospective IFI-BURN Study  Emmanuel Dudoignon,  Sylvie Chevret,  Sorel Tsague,  et al Clinical Infectious Diseases, Volume 79, Issue 3, 15 September 2024, Pages 682–689, https://doi.org/10.1093/cid/ciae337 Abstract Background In burn patients, skin barrier disruption and immune dysfunctions increase susceptibilit...

Editorials Immunotherapies for sepsis and the impact of study design John H Powers III, Charles Natanson BMJ 2025; 388 doi: https://doi.org/10.1136/bmj.r48 (Published 15 January 2025)Cite this as: BMJ 2025;388:r48 Enrolling the right number and type of patient is crucial Sepsis is a life threatening syndrome initiated by microorganisms.1 Severe and often lethal injuries (eg, shock, multiorgan failure, and metabolic derangements) are the manifestation o...

Early Mobilisation, Delirium Prevention and Long-Term Cognitive Function In ICU Tue, 1 Oct 2024 ICU Management & Practice, Volume 24 - Issue 4, 2024 Early mobilisation showed promising positive effects in preventing and shortening delirium and improving long-term cognitive function. Further research is required to confirm its benefits and to identify the best protocol. Introduction In recent years, an increasing demand for critical care s...

Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial Walsham, J., Hammond, N., Blumenthal, A. et al. Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07616-z Abstract Background The combination of intravenous hydrocortisone and enteral fludrocortisone may reduce mortality in patients with septic shock. The optimal dose and reliability of absorption of fludrocortisone in critically ill patients are unclear. ...

Treatment Outcomes Among Patients With a Positive Candida Culture Close to Randomization Receiving Rezafungin or Caspofungin in the ReSTORE Study  Alex Soriano,  Patrick M Honore,  Oliver A Cornely,  et al Clinical Infectious Diseases, Volume 79, Issue 3, 15 September 2024, Pages 672–681, https://doi.org/10.1093/cid/ciae363 Abstract Background Rezafungin, a novel, once-weekly echinocandin for the treatment o...

Research The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial Jianfeng Wu, Fei Pei, Lixin Zhou, et al BMJ 2025; 388 doi: https://doi.org/10.1136/bmj-2024-082583 (Published 15 January 2025)Cite this as: BMJ 2025;388:e082583 Abstract Objective To evaluate whether the immunomodulatory drug thymosin α1 reduces mortality in adults with sepsis. Design Multicentre, double...

Antimicrobial Dosing in Critically Ill Patients on ECMO In ICU Mon, 14 Oct 2024 Extracorporeal membrane oxygenation (ECMO) is used to support critically ill patients, but its impact on antimicrobial pharmacokinetics (PK) and pharmacodynamics (PD) presents significant challenges. ECMO circuits can affect drug delivery, leading to the sequestration of drugs, changes in the volume of distribution (Vd), decreased clearance, and longer elimination half-life...

Original Investigation  Pacific Coast Surgical Association September 4, 2024 Mentorship of Junior Surgical Faculty Across Academic Programs in Surgery Jingjing Yu, Perisa Ruhi-Williams, Christian de Virgilio, et al JAMA Surg. 2024;159(11):1252-1260. doi:10.1001/jamasurg.2024.3390 Key Points Question  What is the current mentorship experience for junior surgical faculty and what are the challenges to re...

Original Investigation  August 21, 2024 High Fresh Frozen Plasma to Red Blood Cell Ratio and Survival Outcomes in Blunt Trauma Gaku Fujiwara, Yohei Okada, Wataru Ishii, et al JAMA Surg. 2024;159(11):1272-1280. doi:10.1001/jamasurg.2024.3097 Key Points Question  What is the association of a high fresh frozen plasma (FFP) to red blood cell (RBC) ratio with survival outcomes in patients with severe blunt tra...

Distinct Clinical Endpoints of Staphylococcus aureus Bacteraemia Complicate Assessment of Outcome  Clark D Russell,  Karla Berry,  George Cooper,  et al Clinical Infectious Diseases, Volume 79, Issue 3, 15 September 2024, Pages 604–611, https://doi.org/10.1093/cid/ciae281 Abstract Background We aimed to test the hypothesis that development of metastatic infection represents a distinct clinical endpoint from death due to&nb...