Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study Megan Bailey, Graeme Fairchild, Gemma Hammerton, et al Lancet Global Health 2025; 13: e309-e318 https://doi.org/10.1016/S2214-109X(24)00452-2 Summary Background The mental health consequences of exposure to childhood trauma have been little studied among adolescents in low-income and-middle-income countries (LMICs), de...

Evaluating culture-free targeted next-generation sequencing for diagnosing drug-resistant tuberculosis: a multicentre clinical study of two end-to-end commercial workflows Rebecca E Colman, Marva Seifert, Andres De la Rossa, et al Lancet Infect Dis Available online 29 October 2024 https://doi.org/10.1016/S1473-3099(24)00586-3 Summary Background Drug-resistant tuberculosis remains a major obstacle in ending the global tuberculosis epidemic. Deployment of ...

The prevalence of hypoxaemia in paediatric and adult patients in health-care facilities in low-income and middle-income countries: a systematic review and meta-analysis Hamish R Graham, Esrat Jahan, Rami Subhi, et al Lancet Global Health 2025; 13: e222-e231 https://doi.org/10.1016/S2214-109X(24)00469-8 Summary Background Hypoxaemia (low oxygen saturation in blood) is a key predictor of in-hospital mortality, affecting people of all ages with many differe...

Leadership in Healthcare Emergency Teams In ICU Tue, 10 Dec 2024 Leadership in emergency healthcare teams is pivotal to ensuring optimal team performance and deserves significant attention. In a recent review, Steinbach et al. (2024) highlight the critical importance of leadership within ad hoc critical care teams. However, their findings reveal that despite substantial efforts to improve teamwork in healthcare, poor leadership persists. This stagnatio...

Effectiveness of 2023 southern hemisphere influenza vaccines against severe influenza-associated illness: pooled estimates from eight countries using the test-negative design Radhika Gharpure, Annette K Regan, Francisco Nogareda, et al Lancet Global Health 2025; 13: e203-e211 https://doi.org/10.1016/S2214-109X(24)00473-X Summary Background Annual estimates of seasonal influenza vaccine effectiveness can guide global risk communication and vaccination str...

Invited Commentary  January 29, 2025 Benzodiazepines Not Main Suspect in Cardiac Surgery Delirium Amanda M. Kleiman, Michael P. Calgi, John S. McNeil JAMA Surg. Published online January 29, 2025 doi:10.1001/jamasurg.2024.6603 Delirium after cardiac surgery continues to confound. Hypotension, emboli, hemorrhage, nonpulsatile flow, medications, preexisting vulnerabilities—the list of likely contributors is robust enough that 1 prime suspect ...

Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study Teresa B Kortz, Adrian Holloway, Asya Agulnik, et al Lancet Global Health 2025; 13: e212-e221 https://doi.org/10.1016/S2214-109X(24)00450-9 Summary Background Children in resource-constrained settings (RCS) have disproportionately high illness and mo...

Safety and efficacy of nipocalimab in adults with generalised myasthenia gravis (Vivacity-MG3): a phase 3, randomised, double-blind, placebo-controlled study Carlo Antozzi, Tuan Vu, Sindhu Ramchandren, et al Lancet Neurol 2025; 24: 105-116 https://doi.org/10.1016/S1474-4422(24)00498-8 Summary Background Given burdensome side-effects and long latency for efficacy with conventional agents, there is a continued need for generalised myasthenia gravis treatme...

Three-Year Mortality of ICU Survivors With Sepsis In Sepsis Tue, 10 Dec 2024 Sepsis is a common cause of ICU admissions and mortality, with its incidence increasing over recent decades. Although hospital mortality has declined, long-term mortality remains high, with 1-year mortality rates for survivors ranging from 7% to 44% and over 2-year mortality exceeding 53%. Factors contributing to this risk are debated, including the direct effects of sepsis, c...

Editor's Note  January 27, 2025 Decision Rules for Termination of Resuscitation—A Roadmap for Challenging Terrain Ilana B. Richman, Sharon K. Inouye, Tracy Wang JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7823 Cardiopulmonary resuscitation (CPR) algorithms generally begin with clear instructions: in the absence of a pulse, begin CPR. When to end resuscitative efforts, though, is much less obvious. Curren...