Oxygen Reactivity Index in Traumatic Brain Injury In ICU Tue, 14 Jan 2025 Moderate-to-severe traumatic brain injury (TBI) often results in impaired cerebral autoregulation (CA), making patients vulnerable to both ischaemia and hyperaemia. The capacity for CA varies between patients and can change over time, complicating the determination of an optimal cerebral perfusion pressure (CPP) target. The pressure reactivity index (PRx), a measure of CA based o...

Research Letter  Health Policy February 19, 2025 Health Care Staffing Shortages and Potential National Hospital Bed Shortage Richard K. Leuchter, Benjo A. Delarmente, Sitaram Vangala, et al JAMA Netw Open. 2025;8(2):e2460645. doi:10.1001/jamanetworkopen.2024.60645 Introduction Between August 2020 and April 2024, US hospitals were mandated to report weekly occupancy to the Department of Health and Human...

Emergency Department Admitting Practices and Mortality In ICU Tue, 7 Jan 2025 Emergency department patients treated by physicians with a high tendency to admit them to the hospital are more likely to be discharged after a short stay, raising concerns about potentially unnecessary admissions. However, new research indicates that these patients are no less likely to die than those treated by low-admitting physicians. A recent study suggests that physi...

A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficile Infection Dimitri M Drekonja, Aasma Shaukat, Yuan Huang, et al Clinical Infectious Diseases, Volume 80, Issue 1, 15 January 2025, Pages 52–60, https://doi.org/10.1093/cid/ciae467 Abstract Background Clostridioides difficile infection (CDI) is the most common cause of healthcare–associated in...

Original Investigation  Critical Care Medicine February 10, 2025 Response to Inhaled Nitric Oxide and Mortality Among Very Preterm Neonates With Pulmonary Hypertension Michelle Baczynski, Dany Weisz, Laura Thomas, et al JAMA Netw Open. 2025;8(2):e2458843. doi:10.1001/jamanetworkopen.2024.58843 Key Points Question  Is there an association between inhaled nitric oxide (iNO) responsiveness and m...

Population Sepsis Incidence, Mortality, and Trends in Hong Kong Between 2009 and 2018 Using Clinical and Administrative Data  Lowell Ling, Jack Zhenhe Zhang, Lok Ching Chang,  et al Clinical Infectious Diseases, Volume 80, Issue 1, 15 January 2025, Pages 91–100, https://doi.org/10.1093/cid/ciad491 Abstract Background Sepsis surveillance using electronic health record (EHR)–based data may provide more accurate epidemiologic esti...

Opportunity Cost of Artificial Intelligence Hesitancy in the ICU In ICU Tue, 7 Jan 2025 Healthcare systems face challenges like increasing patient loads, rising costs, and staff shortages, which hinder consistent, high-quality care. Without integrating artificial intelligence (AI), these issues could worsen, leading to greater disparities in access and care quality. AI offers transformative potential by automating administrative tasks, supporting clini...

Epidemiology and Outcomes of Antibiotic De-escalation in Patients With Suspected Sepsis in US Hospitals Kai Qian Kam, Tom Chen, Sameer S Kadri, et al Clinical Infectious Diseases, Volume 80, Issue 1, 15 January 2025, Pages 108–117, https://doi.org/10.1093/cid/ciae591 Abstract Background Little is known about the frequency, hospital-level variation, predictors, and outcomes of antibiotic de-escalation in suspected sepsis. Methods We...

Comment Effect of normobaric hyperoxia in ischaemic stroke Diederik W J Dippel, Paula M Janssen Lancet 2025; 405: 442-443 DOI: https://doi.org/10.1016/S0140-6736(25)00153-9 In ischaemic stroke, discontinuation of local arterial blood supply to the brain leads to neurological deficits. The assumption that increased delivery of oxygen in patients with acute ischaemic stroke might lead to amelioration of neurological deficit is interesting, but almost all larg...

Original Investigation  Caring for the Critically Ill Patient December 10, 2024 Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial Tobias Arleth, Josefine Baekgaard, Volkert Siersma, et al JAMA. 2025;333(6):479-489. doi:10.1001/jama.2024.25786 Key Points Question  Does an early, 8-hour restrictive oxygen strategy compared with a liberal oxygen stra...