Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial Francis Couturaud, Jeannot Schmidt, Olivier Sanchez, et al Lancet 2025; 405: 725-735 Summary Background In patients with venous thromboembolism at high risk of recurrence for whom extended treatment with direct oral anticoagulants has ...

Editor's Note  February 24, 2025 Patient Portals—Balancing Workload and Opportunity Ilana B. Richman, Ishani Ganguli, Eve Rittenberg JAMA Intern Med. Published online February 24, 2025. doi:10.1001/jamainternmed.2024.8135 Soon after the earliest email systems were developed in the late 1960s, electronic messages began to pile up. The onslaught of messages surprised early adopters and spurred the development of message management systems from ...

Artificial Intelligence to Treat Acute Kidney Injury In ICU Tue, 14 Jan 2025 Acute kidney injury (AKI) often complicates critical illness, with management focusing on supportive care per the Kidney Disease Improving Global Outcomes (KDIGO) guideline due to the lack of specific reversing therapies. Although timely implementation of these guidelines can reduce postoperative moderate and severe AKI, adherence in routine clinical practice remains low. A...

Research Letter  Physician Work Environment and Well-Being February 24, 2025 Trends in Physician Electronic Health Record Time and Message Volume A Jay Holmgren, Nate C. Apathy, Christine A. Sinsky, et al JAMA Intern Med. Published online February 24, 2025. doi:10.1001/jamainternmed.2024.8138 Physician work is increasingly centered around the electronic health record (EHR), which consumes nearly 50% of sc...

Original Investigation  Physician Work Environment and Well-Being February 24, 2025 Mortality Among US Physicians and Other Health Care Workers Vishal R. Patel, Michael Liu, Christopher M. Worsham, et al JAMA Intern Med. Published online February 24, 2025. doi:10.1001/jamainternmed.2024.8432 Key Points Question  How do mortality rates differ by sex, race, and ethnicity among physicians and ot...

The African Critical Illness Outcomes Study (ACIOS): a point prevalence study of critical illness in 22 nations in Africa The African Critical Illness Outcomes Study (ACIOS) Investigators Lancet 2025; 405: 715-724 Summary Background Critical illness represents a major global health-care burden and critical care is an essential component of hospital care. There are few data describing the prevalence, treatment, and outcomes of critically ill patients in Afri...

Research Discrepancies in neglected tropical diseases burden estimates in China: comparative study of real-world data and Global Burden of Disease 2021 data (2004-2020) Guo-Jing Yang, Han-Qi Ouyang, Zi-Yu Zhao, et al BMJ 2025; 388 doi: https://doi.org/10.1136/bmj-2024-080969 (Published 18 February 2025)Cite this as: BMJ 2025;388:e080969 Abstract Objectives To assess the discrepancies between real-world data and the Global Burden of Disease (GBD) 2021 e...

Role of Artificial Intelligence in Scientific Research and Review In ICU Tue, 14 Jan 2025 Recent advances in large language models (LLMs) and generative artificial intelligence (AI) have led to the rapid integration of AI tools into research. These tools are now used to assist with literature reviews, data management and analysis, data synthesis, and editing scientific writing. Additionally, many medical journals utilise AI for tasks such as plagiarism...

Research Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial Leilei Wang, Yuanyuan Zhang, Dan Han, et al BMJ 2025; 388 doi: https://doi.org/10.1136/bmj-2024-080795 (Published 11 February 2025)Cite this as: BMJ 2025;388:e080795 Abstract Objective To determine whether high flow nasal cannula (HFNC) oxygenation can reduce the incid...

Research Letter  February 17, 2025 Heterogeneity of Primary Outcomes in Large Atherosclerotic Cardiovascular Disease Trials Published in Prominent Medical Journals Daniel Shepshelovich, Dafna Yahav, Danielle R. Rome, et al JAMA Intern Med. Published online February 17, 2025. doi:10.1001/jamainternmed.2024.7694 The extent of heterogeneity in end points reported by randomized clinical trials (RCTs) of atherosc...