Original Investigation  Pediatrics March 6, 2025 Trends in Respiratory Pathogen Testing at US Children’s Hospitals Matthew J. Molloy, Matthew Hall, Jessica L. Markham, et al JAMA Netw Open. 2025;8(3):e250160. doi:10.1001/jamanetworkopen.2025.0160 Key Points Question  How have respiratory pathogen testing rates and costs changed over time for children and adolescents with acute respiratory inf...

AI-Guided Lung Ultrasound Performed by Non-Experts In ICU Mon, 27 Jan 2025 Lung ultrasound (LUS) is increasingly used for diagnosing and monitoring shortness of breath due to its portability, low cost, and lack of radiation exposure. It provides real-time lung assessments and is more accurate than chest radiography in detecting conditions such as pneumonia, pneumothorax, pleural effusion, and pulmonary oedema. LUS is particularly useful in emergency de...

Comment Anticoagulation for extended venous thromboembolism treatment: less is really more Saskia Middeldorp, Jenneke Leentjens Lancet 2025; 405: 676-677 Venous thromboembolism, comprising pulmonary embolism and deep vein thrombosis, is a common disease with considerable mortality and morbidity, such as post-thrombotic and post-pulmonary-embolism syndrome.1, 2 Anticoagulation is the main treatment for venous thromboembolism, although the decision on ...

Original Investigation  March 5, 2025 Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage: A Randomized Clinical Trial Juha K. A. Rinne, Heikki Huhta, Tarja Pinta, et al JAMA Surg. Published online March 5, 2025. doi:10.1001/jamasurg.2025.0006 Key Points Question  Does the routine use of indocyanine green (ICG) fluorescence imaging decrease the rate of anastomo...

Original Investigation  March 3, 2025 Population-Scale Studies of Protein S Abnormalities and Thrombosis Sharjeel A. Chaudhry, Amelia K. Haj, Justine Ryu, et al JAMA. Published online March 3, 2025. doi:10.1001/jama.2025.0155 Key Points Question  What is the thrombosis risk conferred by deficiency in protein S? Findings  In this analysis of more than 600 000 individuals, we found th...

Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock In Sepsis Mon, 27 Jan 2025 Over 50 RCTs have examined resuscitation strategies in sepsis, but the optimal approach remains unclear. Early goal-directed therapy (EGDT), a 6-hour protocol involving fluids, vasopressors, inotropes, and blood products, showed a significant reduction in mortality in a landmark trial. However, subsequent larger trials did not replicate these benefits...

Understanding the scale of critical illness in Africa and the need for universal access to emergency and critical care Nazir I Lone, John A Masterson, Swagata Tripathy Lancet 2025; 405: 674-675 Timely access to critical care saves lives in any health-care context. In high-income settings, the term critical care is associated with a geographically defined location within a hospital, equipped with advanced technologies requiring substantial financial resourcing. Ho...

Original Investigation  March 3, 2025 Multivitamins After Myocardial Infarction in Patients With Diabetes: A Randomized Clinical Trial Francisco Ujueta, Gervasio A. Lamas, Kevin J. Anstrom, et al JAMA Intern Med. Published online March 3, 2025. doi:10.1001/jamainternmed.2024.8408 Key Points Question  In participants with diabetes and prior myocardial infarction (MI), do oral multivitamins and mu...

Original Investigation  January 13, 2025 Antiviral Medications for Treatment of Nonsevere Influenza: A Systematic Review and Network Meta-Analysis Ya Gao, Yunli Zhao, Ming Liu, et al JAMA Intern Med. 2025;185(3):293-301. doi:10.1001/jamainternmed.2024.7193 Key Points Question  What is the optimal antiviral drug in the treatment of patients with nonsevere influenza virus infection? Findings  I...

Weaning of NIV in Children With a Nurse-Driven Protocol  In ICU Thu, 28 Nov 2024 ICU Management & Practice, Volume 24 - Issue 5, 2024 Shortening the weaning process of children receiving non-invasive ventilation (NIV) is challenging. We present the results of implementing a nurse-guided weaning protocol in our PICU.  Introduction   Given the low mortality rate in paediatrics, the management of acute respiratory insufficienc...