Editor's Note  January 13, 2025 The Limited Role for Antiviral Therapy in Influenza Jonathan D. Baghdadi, Deborah Grady, Daniel J. Morgan JAMA Intern Med. Published online January 13, 2025. doi:10.1001/jamainternmed.2024.7258 Influenza is associated with substantial morbidity and mortality. Given this, antiviral therapy is commonly prescribed in an effort to prevent these outcomes. We therefore found it surprising that antivirals seem to make...

Original Investigation  Infectious Diseases January 15, 2025 Blood Culture Use in Medical and Surgical Intensive Care Units and Wards Valeria Fabre, Yea-Jen Hsu, Karen C. Carroll, et al JAMA Netw Open. 2025;8(1):e2454738. doi:10.1001/jamanetworkopen.2024.54738 Key Points Question  What is the blood culture use rate of medical and medical-surgical intensive care units (ICUs) and wards in the U...

Rethinking Septic Shock Management: Potential of Early Vasopressin Use to Enhance Patient Outcomes In ICU Thu, 28 Nov 2024 ICU Management & Practice, Volume 24 - Issue 5, 2024 Vasopressin timing, patient selection, optimal vasopressin use in septic shock, and potential mortality benefits in selected patient populations. Septic Shock Overview and Current Treatments Septic shock is a severe, life-threatening response to infection, character...

Original Investigation  January 15, 2025 Palliative Care Initiated in the Emergency Department: A Cluster Randomized Clinical Trial Corita R. Grudzen, Nina Siman, Allison M. Cuthel, et al JAMA. Published online January 15, 2025. doi:10.1001/jama.2024.23696 Key Points Question  What is the effect of a multicomponent intervention to initiate palliative care in the emergency department on hospital ...

Invited Commentary  Medical Education January 9, 2025 Another Resident Survey—Useful to Whom? Julie L. Oyler, Jason T. Alexande JAMA Netw Open. 2025;8(1):e2454054. doi:10.1001/jamanetworkopen.2024.54054 Grbic and colleagues1 performed a cross-sectional study examining whether program director (PD) assessments of postgraduate year 1 (PGY-1) resident performance during the transition to residency differed by specialt...

Hypotension and Adverse Outcomes in Traumatic Brain Injury In ICU Mon, 18 Nov 2024 Traumatic brain injury (TBI) is a major cause of death and disability, with 60 million cases annually and 8.1 million years of disability worldwide. Hypotension, a common secondary injury in TBI, often results from blood loss or neurogenic causes like myocardial depression or brainstem herniation disrupting autonomic control. Hypotension significantly worsens outcomes, i...

Original Investigation  January 13, 2025 Antiviral Medications for Treatment of Nonsevere Influenza: A Systematic Review and Network Meta-Analysis Ya Gao, Yunli Zhao, Ming Liu, et al JAMA Intern Med. Published online January 13, 2025. doi:10.1001/jamainternmed.2024.7193 Key Points Question  What is the optimal antiviral drug in the treatment of patients with nonsevere influenza virus infection? ...

Invited Commentary  January 2, 2025 Silent Cost of Private Equity Hospitals Aaron R. Dezube, Virginia R. Litle JAMA Surg. Published online January 2, 2025. doi:10.1001/jamasurg.2024.5983 As private equity acquisition of acute care hospitals increases across the US,1,2 it is time we examine not only the finance differentials of hospital ownership, but also the cost for patient surgical outcomes. Quality of care has appropriately become a ...

Original Investigation  Public Health January 8, 2025 Irritability and Social Media Use in US Adults Roy H. Perlis, Ata Uslu, Jonathan Schulman, et al JAMA Netw Open. 2025;8(1):e2452807. doi:10.1001/jamanetworkopen.2024.52807 Key Points Question  Is social media use by adults associated with irritability, or being prone to anger? Findings  In this survey study of 42 597 US adults...

Original Investigation  November 27, 2024 Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery: A Randomized Clinical Trial Hugh Paterson, Thenmalar Vadiveloo, Karen Innes, et al JAMA. 2025;333(1):39-48. doi:10.1001/jama.2024.23898 Key Points Question  Does perioperative administration of 2% intravenous (IV) lidocaine affect postoperative return of gut function in adult patients un...