Original Investigation  January 29, 2025 Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium: A Cluster Randomized Crossover Trial Jessica Spence, P. J. Devereaux, Shun-Fu Lee, et al JAMA Surg. Published online January 29, 2025 doi:10.1001/jamasurg.2024.6602 Key Points Question  Does an institutional policy restricting benzodiazepines during cardiac anesthesia reduc...

Current Approaches to Non-Invasive Ventilation in Critically Ill Patients In ICU Thu, 28 Nov 2024 ICU Management & Practice, Volume 24 - Issue 5, 2024 Non-invasive ventilation is extensively employed in the management of acute hypoxaemic and hypercapnic respiratory failure, offering a potential means to circumvent intubation in carefully selected patients under vigilant supervision. Non-Invasive Ventilation Non-invasive ventilation (NIV) ...

Research Letter  January 27, 2025 Cardiac Biomarker Testing in US Emergency Departments Cian P. McCarthy, Nathan W. Watson, Jason H. Wasfy, et al JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7554 Patient characteristics and presenting symptoms are used in risk stratification for individuals evaluated in the emergency department (ED) as to their likelihood of having acute...

Original Investigation  January 27, 2025 Termination of Resuscitation Rules for In-Hospital Cardiac Arrest Mathias J. Holmberg, Asger Granfeldt, Ari Moskowitz, et al JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7814 Key Points Question  Can a clinical decision rule guide termination of resuscitation efforts during in-hospital cardiac arrest? Findings ...

Invited Commentary  January 15, 2025 Tranexamic Acid in General Surgery—Who Benefits the Most? Marjorie Liggett, Hasan Alam JAMA Surg. Published online January 15, 2025. doi:10.1001/jamasurg.2024.6060 Tranexamic acid (TXA) is not a new drug. First discovered by Utako Okamoto in 1962,1 it regained attention decades later after the CRASH-2 (Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma pati...

Original Investigation  January 27, 2025 Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial SUNRRISE Trial Study Group JAMA. Published online January 27, 2025. doi:10.1001/jama.2024.24764 Key Points Question  Among patients undergoing emergency laparotomy, is there a difference in surgical site infection (SSI) rates when the wound is treated with ...

Tracheostomy Management: From Intensive Care to Community In ICU Thu, 28 Nov 2024 ICU Management & Practice, Volume 24 - Issue 5, 2024 Tracheostomies are widely performed for a variety of reasons in the ICU. This article outlines the process of transitioning from critical care to the community with proactive management by a multidisciplinary team to wean patients from the ventilator and from the tracheostomy.  Introduction Approximat...

Invited Commentary  January 15, 2025 Turning Stress Into Success—Surgery as Professional Sport Steven Yule, Jennifer Yule, Calum Arthur JAMA Surg. Published online January 15, 2025. doi:10.1001/jamasurg.2024.6041 In the latest issue of JAMA Surgery, Awtry et al1 report that elevated surgeon stress, measured by heart rate variability (HRV) within the first 5 minutes of operating, is inversely associated ...

Original Investigation  Diabetes and Endocrinology January 21, 2025 Use of Albumin-Adjusted Calcium Measurements in Clinical Practice Noémie Desgagnés, James A. King, Gregory A. Kline, et al JAMA Netw Open. 2025;8(1):e2455251. doi:10.1001/jamanetworkopen.2024.55251 Key Points Question  How accurate are the calcium adjustment formulas that are used in clinical practice? Findings  ...

Editorial  March 18, 2025 Sevoflurane Sedation in Acute Respiratory Distress Syndrome: Time to Put It to Sleep Balasubramanian Venkatesh, Naomi Hammond, Anthony Delaney JAMA. Published online March 18, 2025. doi:10.1001/jama.2025.3023 Acute respiratory distress syndrome (ARDS) is characterized by hypoxemic respiratory failure and inflammatory injury to the lungs, and occurs in 10% of all intensive care unit admissions. ARDS accounts for nearl...