Original Investigation  January 27, 2025 Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial SUNRRISE Trial Study Group JAMA. 2025;333(10):853-863. doi:10.1001/jama.2024.24764 Key Points Question  Among patients undergoing emergency laparotomy, is there a difference in surgical site infection (SSI) rates when the wound is treated with incisional negative pre...

Invited Commentary  Pediatrics March 6, 2025 Changes in Respiratory Viral Testing Before and After the COVID-19 Pandemic Todd W. Lyons, Caroline G. Kahane JAMA Netw Open. 2025;8(3):e250168. doi:10.1001/jamanetworkopen.2025.0168 As an intern during the winter of 2008, I presented a full service of children admitted overnight with bronchiolitis. It had been 2 years since the initial publication of the American Academy of Pediatrics’ “Diagno...

Original Investigation  March 10, 2025 Awake Prone Positioning in Adults With COVID-19: An Individual Participant Data Meta-Analysis Jian Luo, Ivan Pavlov, Elsa Tavernier, et al JAMA Intern Med. Published online March 10, 2025. doi:10.1001/jamainternmed.2025.0011 Key Points Question  Is awake prone positioning (APP) associated with better odds of survival without intubation compared with supine ...

AI-Powered Prediction Model to Enhance Blood Transfusion Decision-Making  In ICU Fri, 24 Jan 2025 Researchers at Emory University have developed an advanced artificial intelligence (AI) model that accurately predicts the need for blood transfusions in non-traumatic ICU patients. Published in Health Data Science, the study tackles longstanding challenges in forecasting transfusion requirements across diverse patient populations with varying me...

ARTICLESVolume 405, Issue 10481P839-849March 08, 2025Download Full Issue Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in China Anwen Xiong, Lei Wang, Jianhua Chen, et al Lancet 2025; 405: 839-849 Summary Background Ivonescimab is a bispecific antibody against programmed cell death protein 1 and vascular endothelial growth factor, yielding promising clinical outc...

Invited Commentary  March 5, 2025 Indocyanine Green Fluorescence for Colectomy—Better Than the Naked Eye? Matthew Z. Wilson, David B. Stewart JAMA Surg. Published online March 5, 2025. doi:10.1001/jamasurg.2025.0015 Anastomotic leaks (ALs) are often devastating complications that frequently require unplanned reoperation, creation of a stoma that may be permanent, and months of management until the potential restoration of gut continuity.1&nbs...

ARTICLESVolume 405, Issue 10481P813-838March 08, 2025Open AccessDownload Full Issue Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021 GBD 2021 Adult BMI Collaborators Lancet 2025; 405: 813-838 Summary Background Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing...

In-hospital Mortality in Patients Admitted to IMCUs With and Without ICUs In ICU Mon, 27 Jan 2025 ICUs provide critical treatment for severely ill patients but are resource-intensive and costly, requiring efficient and equitable utilisation. Guidelines for ICU admission and discharge have been established in several countries to optimise resource use. Intermediate care units (IMCUs), also known as high-dependency or step-down units, offer care for pati...

ONLINE FIRST (FREE ACCESS) Artificial Intelligence in ICU Collection Editorial Setting the ventilator with AI support: challenges and perspectives Fritsch S. J. & Cecconi M. Natural language processing in critical care: opportunities, challenges, and future directionsMcNicholas B. A., Madden M. G. & Laffey J. G. Using AI to detect and treat delirium Young M., Kotfis K. & Bellomo R. OPEN ACCESS ~ Editorial How AI can help in erro...

ARTICLESVolume 405, Issue 10481P785-812March 08, 2025 Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021 GBD 2021 Adolescent BMI Collaborators Lancet 2025; 405: 785-812 Summary Background Despite the well documented consequences of obesity during childhood and adolescence and future risks of excess body mass on non-com...