Editor's Note  January 27, 2025 Decision Rules for Termination of Resuscitation—A Roadmap for Challenging Terrain Ilana B. Richman, Sharon K. Inouye, Tracy Wang JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7823 Cardiopulmonary resuscitation (CPR) algorithms generally begin with clear instructions: in the absence of a pulse, begin CPR. When to end resuscitative efforts, though, is much less obvious. Curren...

Effectiveness of ceftazidime–avibactam versus ceftolozane–tazobactam for multidrug-resistant Pseudomonas aeruginosainfections in the USA (CACTUS): a multicentre, retrospective, observational study Ryan K Shields, Lilian M Abbo, Renee Ackley, et al Lancet Infect Dis Available online 16 December 2024 https://doi.org/10.1016/S1473-3099(24)00648-0 Summary Background Ceftolozane–tazobactam and ceftazidime–avibactam are preferred treatment options for multidru...

Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021 GBD 2021 Diarrhoeal Diseases Collaborators Lancet Infectious Diseases Available online 18 December 2024 https://doi.org/10.1016/S1473-3099(24)00691-1 Summary Background Diarrhoeal diseases claim more than 1 million lives annually and...

Safety of AI in Real-World Clinical Care In ICU Tue, 10 Dec 2024 The integration of AI tools into clinical practice is advancing rapidly, but mechanisms to ensure their safety and effectiveness remain insufficient. That is why healthcare organisations (HCOs) and clinicians face challenges in adopting AI responsibly.  Risks like model drift, algorithmic errors, biases, and overfitting have already been observed in early AI applications, resultin...

Robust Meta-Model for Predicting the Likelihood of Receiving Blood Transfusion in Non-traumatic Intensive Care Unit Patients ALIREZA RAFIEI , RONALD MOORE, TILENDRA CHOUDHARY, et al HEALTH DATA SCIENCE 2024; 4: 0197 DOI: 10.34133/hds.0197 Abstract Background: Blood transfusions, crucial in managing anemia and coagulopathy in intensive care unit (ICU) settings, require accurate prediction for effective resource allocation and patient risk assessment. However...

Editorials Surgical adverse events in the US Helen Haskell BMJ 2024; 387 doi: https://doi.org/10.1136/bmj.q2437 (Published 13 November 2024)Cite this as: BMJ 2024;387:q2437 After all these years, why has patient safety not improved? In late 1999, the US Institute of Medicine’s report “To Err is Human: Building a Safer Health System” galvanized the nascent patient safety movement into action with its assertion that as many ...

Original Investigation  January 29, 2025 Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium: A Cluster Randomized Crossover Trial Jessica Spence, P. J. Devereaux, Shun-Fu Lee, et al JAMA Surg. Published online January 29, 2025 doi:10.1001/jamasurg.2024.6602 Key Points Question  Does an institutional policy restricting benzodiazepines during cardiac anesthesia reduc...

Current Approaches to Non-Invasive Ventilation in Critically Ill Patients In ICU Thu, 28 Nov 2024 ICU Management & Practice, Volume 24 - Issue 5, 2024 Non-invasive ventilation is extensively employed in the management of acute hypoxaemic and hypercapnic respiratory failure, offering a potential means to circumvent intubation in carefully selected patients under vigilant supervision. Non-Invasive Ventilation Non-invasive ventilation (NIV) ...

Research Letter  January 27, 2025 Cardiac Biomarker Testing in US Emergency Departments Cian P. McCarthy, Nathan W. Watson, Jason H. Wasfy, et al JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7554 Patient characteristics and presenting symptoms are used in risk stratification for individuals evaluated in the emergency department (ED) as to their likelihood of having acute...

Original Investigation  January 27, 2025 Termination of Resuscitation Rules for In-Hospital Cardiac Arrest Mathias J. Holmberg, Asger Granfeldt, Ari Moskowitz, et al JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7814 Key Points Question  Can a clinical decision rule guide termination of resuscitation efforts during in-hospital cardiac arrest? Findings ...