Original Investigation  January 15, 2025 Safety and Efficacy of Tranexamic Acid in General Surgery Lily J. Park, Maura Marcucci, Sandra N. Ofori, et al JAMA Surg. Published online January 15, 2025. doi:10.1001/jamasurg.2024.6048 Key Points Question  What is the safety and efficacy profile of prophylactic tranexamic acid (TXA) use in general surgery? Findings  In this substudy of a r...

Monitoring and ICP-Driven Therapies in TBI Using nICP Systems In ICU Tue, 4 Feb 2025 Intracranial hypertension after traumatic brain injury (TBI) leads to secondary brain damage, high mortality, and poor outcomes. Invasive intracranial pressure (ICP) monitoring using intraparenchymal or intraventricular systems is the gold standard for guiding TBI treatment. The Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) developed...

Research Safety of inpatient care in surgical settings: cohort study Antoine Duclos, Michelle L Frits, Christine Iannaccone, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-080480 (Published 13 November 2024)Cite this as: BMJ 2024;387:e080480 Abstract Objectives To estimate the frequency, severity, and preventability of adverse events associated with perioperative care, and to describe the setting and professions concerned. Design Mul...

Ventilatory Support for Asthma - An Overview of Critical Asthma Management In ICU Thu, 28 Nov 2024 ICU Management & Practice, Volume 24 - Issue 5, 2024 Critical asthma is relatively uncommon, with its incidence on the decline; however, it can require intensive care, including mechanical ventilation. This article provides an overview of critical asthma management. Critical asthma (CA) is an umbrella term embracing different definitions, all r...

Adverse Prehospital Events and Outcomes After TBI In ICU Tue, 4 Feb 2025 Traumatic brain injury (TBI) is a major global health issue, affecting approximately 70 million people annually. Severe TBI can lead to death or irreversible disability within hours. Emergency medical services (EMS) provide initial care guided by the Brain Trauma Foundation (BTF) guidelines, which focus on preventing secondary brain injury by managing hypoxia, hypotension, and hyp...

Original Investigation  Infectious Diseases March 14, 2025 Antimicrobial-Resistant Infections in Hospitalized Patients Hannah Wolford, Natalie L. McCarthy, James Baggs, et al JAMA Netw Open. 2025;8(3):e2462059. doi:10.1001/jamanetworkopen.2024.62059 Key Points Question  How has antimicrobial resistance changed from 2012 to 2022? Findings  In this cohort study of 7 158 139 culture...

Invited Commentary  March 10, 2025 Awake Prone Positioning in COVID-19—Is There a New Standard of Care? Michael A. Matthay, Katherine D. Wick, Narges Alipanah-Lechner JAMA Intern Med. Published online March 10, 2025. doi:10.1001/jamainternmed.2025.0021 In this issue of JAMA Internal Medicine, Luo et al1 presented compelling evidence for awake prone positioning for patients with acute hypoxemic respiratory failure from COVID-19. Thei...

Original Investigation  Infectious Diseases March 14, 2025 Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial Silvia Bettocchi, Anna Comotti, Marina Elli, et al JAMA Netw Open. 2025;8(3):e250669. doi:10.1001/jamanetworkopen.2025.0669 Key Points Question  Does a probiotic mixture containing Bifidobacterium breve M-16V, ...

SUNRRISE: Negative Pressure Dressings to Prevent SSI After Emergency Laparotomy In ICU Tue, 4 Feb 2025 Surgical site infections (SSI) occur in up to 40% of patients after emergency laparotomy, leading to delayed healing, wound dehiscence, hernia risk, longer hospital stays, and higher readmission rates. These infections are a significant burden on patients, hospitals, and healthcare systems. Emergency laparotomies are critical for treating conditions l...

Original Investigation Emergency Medicine March 14, 2025 Therapy Dogs for Anxiety in Children in the Emergency Department: A Randomized Clinical Trial Heather P. Kelker, Huma K. Siddiqui, Alan M. Beck, et al JAMA Netw Open. 2025;8(3):e250636. doi:10.1001/jamanetworkopen.2025.0636 Key Points Question  Can adjunctive use of therapy dogs in child-life therapy reduce both child-reported anxiety and pa...