ARTIFICIAL INTELLIGENCE IN ICU Editorial Using AI to detect and treat delirium Young M., Kotfis K. & Bellomo R. LATEST ARTICLES Original ESICM consensus-based recommendations for the management of very old patients in intensive care Beil M., Alberto L., Bourne R. S., et al. Serum chloride concentration and outcomes in adults receiving intravenous fluid therapy with a balanced crystalloid solution or 0.9% sodium chloride Ramanan M., Hammond N...

Original Investigation  Oncology March 27, 2025 Late-Onset Immune-Related Adverse Events After Immune Checkpoint Inhibitor Therapy Sienna M. Durbin, Leyre Zubiri, Katherine Perlman, et al JAMA Netw Open. 2025;8(3):e252668. doi:10.1001/jamanetworkopen.2025.2668 Key Points Question  What is the frequency of late-onset immune-related adverse events (irAEs) among patients treated with immune chec...

Editorial  May 19, 2025 The Case for Economic Analyses in Trials With a No Effect Primary Outcome Brian H. Cuthbertson, Gordon Rubenfeld JAMA Netw Open. 2025;8(5):e2517477. doi:10.1001/jamanetworkopen.2025.17477 In this edition of JAMA Network Open, the article “Cost-Effectiveness of α2-Agonists for Intravenous Sedation in Patients With Critical Illness”1 derives from an in-trial cost-utility analysis of a 3-drug regimen for...

Original Investigation  March 26, 2025 Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis Writing Committee for the PERSIST Collaborators JAMA. Published online March 26, 2025. doi:10.1001/jama.2025.2033 Key Points Question  What is the long-term risk of stroke after transient ischemic attack (TIA) or minor stroke? Findings  In this systematic review a...

Invited Commentary  Surgery March 25, 2025 Robotic-Assisted Cholecystectomy—for Whom? David R. Urbach JAMA Netw Open. 2025;8(3):e251711. doi:10.1001/jamanetworkopen.2025.1711 To assess whether robotic-assisted cholecystectomy is superior to laparoscopic cholecystectomy in the prevention of bile duct injury, Mullens and colleagues1 conducted a retrospective study of 737 908 Medicare beneficiaries, including 295 807 in an experimental c...

Original Investigation  Caring for the Critically Ill Patient April 14, 2025 Use of Life Support and Outcomes Among Patients Admitted to Intensive Care Units Emily E. Moin, Nicholas J. Seewald, Scott D. Halpern JAMA. Published online April 14, 2025. doi:10.1001/jama.2025.2163 Key Points Question  How have intensive care unit (ICU) care and outcomes changed in the United States over the past decade? Findings  In th...

Editorial  May 19, 2025 The Search for the Single Best Sedative Edward T. Qian, Todd W. Rice JAMA. Published online May 19, 2025. doi:10.1001/jama.2025.7359 Critically ill patients receiving invasive mechanical ventilation often require continuous infusion of sedation to address pain and anxiety. The search for the single best sedative agent for critically ill patients has been the topic of investigations for decades. Propofol, a lipid-based ...

Original Investigation  March 26, 2025 Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing: The PREPARE Pilot Randomized Clinical Trial Joseph Francis De Luca, Sara Vogrin, Natasha Elizabeth Holmes, et al JAMA Surg. Published online March 26, 2025. doi:10.1001/jamasurg.2025.0279 Key Points Question  Can penicillin and cephalosporin allergy delabeling be performed...

Original Investigation  Critical Care Medicine May 19, 2025 Cost-Effectiveness of α2 Agonists for Intravenous Sedation in Patients With Critical Illness Stephen Morris, Nazir I. Lone, Cathrine A. McKenzie, et al JAMA Netw Open. 2025;8(5):e2517533. doi:10.1001/jamanetworkopen.2025.17533 Key Points Question  What is the cost-effectiveness of dexmedetomidine, clonidine, and propofol for intravenous sedation in patients with ...

Original Investigation  Critical Care Medicine March 25, 2025 Recovery Potential in Patients After Cardiac Arrest Who Die After Limitations or Withdrawal of Life Support Jonathan Elmer, Patrick J. Coppler, Cecelia Ratay, et al JAMA Netw Open. 2025;8(3):e251714. doi:10.1001/jamanetworkopen.2025.1714 Key Points Question  How often do experts believe that there was recovery potential in patients who had limitations or withdrawal ...