The Value of Viewing Burnout as a Relationship Crisis In ICU Mon, 10 Mar 2025 ICU Management & Practice, Volume 25 - Issue 1, 2025 Understanding burnout in the ICU setting requires a nuanced approach that goes beyond recognising its symptoms. It demands that leaders address the structural and environmental factors that contribute to chronic stress, in addition to interventions that support resilience and well-being. The intensive care enviro...

ORIGINAL ARTICLE Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis Kathryn Maitland, San Maurice Ouattara, Hadiza Sainna, et al N Engl J Med Published June 13, 2025 DOI: 10.1056/NEJMoa2505752 Abstract BACKGROUND International recommendations advise against the use of intravenous rehydration therapy in children with severe acute malnutrition because of the concern about fluid overload, but evidence to support this concern is la...

ORIGINAL ARTICLE Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation Karen J. Bosma, Karen E.A. Burns, Claudio M. Martin, et al N Engl J Med Published June 13, 2025 DOI: 10.1056/NEJMoa2505708 Abstract BACKGROUND In critically ill patients, acceleration of liberation from mechanical ventilation is important in order to reduce the risk of complications and to improve long-term outcomes. Whether the use of proportional-a...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original A consensus of European experts on the definition of ventilator-associated pneumonia recurrences obtained by the Delphi method: the RECUVAP study Gaillet A., Luyt C-E., Timsit J-F. et al. Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database Gajdos L., Buetti N., Tabah A. et al. ...

ORIGINAL ARTICLE Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza Arnold S. Monto, Klaus Kuhlbusch, Corrado Bernasconi, et al N Engl J Med 2025;392:1582-1593 Abstract BACKGROUND Baloxavir marboxil (baloxavir) rapidly reduces influenza virus shedding, which suggests that it may reduce transmission. Studies of treatment with neuraminidase inhibitors have not shown sufficient evidence that they prevent transmission to contacts. MET...

The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance Hatim Sati, Elena Carrara, Alessia Savoldi, et al Lancet Infect Dis 2025 https://doi.org/10.1016/S1473-3099(25)00118-5 Summary Background The 2017 WHO Bacterial Priority Pathogens List (BPPL) has been instrumental in guiding global policy, research and development, and investments to address the...

Net Albumin Leakage in Patients With Suspected Sepsis In Sepsis Wed, 12 Mar 2025 Sepsis is a major cause of mortality worldwide, with intravenous crystalloid infusion being the first-line treatment to maintain organ perfusion. However, fluid overload is associated with poor outcomes, and restrictive fluid therapy has not shown benefits. Albumin, due to its molecular properties, may help retain fluid intravascularly, but its volume-sparing effect in sep...

Research Letter  February 12, 2025 Trends in Travel Time to Obtain Surgical Care for Rural Patients Cody Lendon Mullens, Reagan A. Collins, Nicholas Kunnath, et al JAMA. 2025;333(16):1453-1455. doi:10.1001/jama.2025.0447 Timely access to health care services is increasingly threatened for rural residents, with 151 rural hospitals closing between 2010 and 2024.1,2 Compared with nonprocedural services, provision of surgical care faces unique ongoing...

Original Investigation  Caring for the Critically Ill Patient Augmented Enteral Protein During Critical Illness: The TARGET Protein Randomized Clinical Trial Matthew J. Summers, Lee-anne S. Chapple, Amalia Karahalios, et al JAMA Published Online: June 11, 2025 doi: 10.1001/jama.2025.9110 Key Points Question  Does augmentation of enteral protein improve outcomes in critically ill patients? Findings  In this cluster randomize...

Invited Commentary  April 10, 2025 Cutting the Antibiotic Spectrum for Low-Risk Abdominal Infection Joshua B. Brown JAMA Surg. Published online April 10, 2025. doi:10.1001/jamasurg.2025.1107 The rise of antibiotic stewardship efforts has seen success, but evidence is heterogeneous across different conditions. Intra-abdominal infection is one such area where there is a relative paucity of data for effective stewardship interventions. Given the...