In-hospital Mortality in Patients Admitted to IMCUs With and Without ICUs In ICU Mon, 27 Jan 2025 ICUs provide critical treatment for severely ill patients but are resource-intensive and costly, requiring efficient and equitable utilisation. Guidelines for ICU admission and discharge have been established in several countries to optimise resource use. Intermediate care units (IMCUs), also known as high-dependency or step-down units, offer care for pati...

ONLINE FIRST (FREE ACCESS) Artificial Intelligence in ICU Collection Editorial Setting the ventilator with AI support: challenges and perspectives Fritsch S. J. & Cecconi M. Natural language processing in critical care: opportunities, challenges, and future directionsMcNicholas B. A., Madden M. G. & Laffey J. G. Using AI to detect and treat delirium Young M., Kotfis K. & Bellomo R. OPEN ACCESS ~ Editorial How AI can help in erro...

ARTICLESVolume 405, Issue 10481P785-812March 08, 2025 Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021 GBD 2021 Adolescent BMI Collaborators Lancet 2025; 405: 785-812 Summary Background Despite the well documented consequences of obesity during childhood and adolescence and future risks of excess body mass on non-com...

Original Investigation  Pediatrics March 6, 2025 Trends in Respiratory Pathogen Testing at US Children’s Hospitals Matthew J. Molloy, Matthew Hall, Jessica L. Markham, et al JAMA Netw Open. 2025;8(3):e250160. doi:10.1001/jamanetworkopen.2025.0160 Key Points Question  How have respiratory pathogen testing rates and costs changed over time for children and adolescents with acute respiratory inf...

AI-Guided Lung Ultrasound Performed by Non-Experts In ICU Mon, 27 Jan 2025 Lung ultrasound (LUS) is increasingly used for diagnosing and monitoring shortness of breath due to its portability, low cost, and lack of radiation exposure. It provides real-time lung assessments and is more accurate than chest radiography in detecting conditions such as pneumonia, pneumothorax, pleural effusion, and pulmonary oedema. LUS is particularly useful in emergency de...

Comment Anticoagulation for extended venous thromboembolism treatment: less is really more Saskia Middeldorp, Jenneke Leentjens Lancet 2025; 405: 676-677 Venous thromboembolism, comprising pulmonary embolism and deep vein thrombosis, is a common disease with considerable mortality and morbidity, such as post-thrombotic and post-pulmonary-embolism syndrome.1, 2 Anticoagulation is the main treatment for venous thromboembolism, although the decision on ...

Original Investigation  March 5, 2025 Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage: A Randomized Clinical Trial Juha K. A. Rinne, Heikki Huhta, Tarja Pinta, et al JAMA Surg. Published online March 5, 2025. doi:10.1001/jamasurg.2025.0006 Key Points Question  Does the routine use of indocyanine green (ICG) fluorescence imaging decrease the rate of anastomo...

Original Investigation  March 3, 2025 Population-Scale Studies of Protein S Abnormalities and Thrombosis Sharjeel A. Chaudhry, Amelia K. Haj, Justine Ryu, et al JAMA. Published online March 3, 2025. doi:10.1001/jama.2025.0155 Key Points Question  What is the thrombosis risk conferred by deficiency in protein S? Findings  In this analysis of more than 600 000 individuals, we found th...

Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock In Sepsis Mon, 27 Jan 2025 Over 50 RCTs have examined resuscitation strategies in sepsis, but the optimal approach remains unclear. Early goal-directed therapy (EGDT), a 6-hour protocol involving fluids, vasopressors, inotropes, and blood products, showed a significant reduction in mortality in a landmark trial. However, subsequent larger trials did not replicate these benefits...

Understanding the scale of critical illness in Africa and the need for universal access to emergency and critical care Nazir I Lone, John A Masterson, Swagata Tripathy Lancet 2025; 405: 674-675 Timely access to critical care saves lives in any health-care context. In high-income settings, the term critical care is associated with a geographically defined location within a hospital, equipped with advanced technologies requiring substantial financial resourcing. Ho...