Original Investigation  Infectious Diseases March 21, 2025 Seven vs Fourteen Days of Antibiotics for Gram-Negative Bloodstream Infection: A Systematic Review and Noninferiority Meta-Analysis Todd C. Lee, Connor J. Prosty, Michael Fralick, et al JAMA Netw Open. 2025;8(3):e251421. doi:10.1001/jamanetworkopen.2025.1421 Key Points Question  Are 7 days of antibiotic therapy adequate for the treatm...

Balancing Risk and Benefit: The Role of CT in Sepsis Management In Sepsis Sun, 2 Feb 2025 Sepsis remains a leading cause of morbidity and mortality, requiring rapid and precise intervention to improve patient outcomes. Early detection and management are critical, as delayed treatment can significantly increase the risk of progression to septic shock and multiple organ failure. Computed tomography (CT) is widely used to identify infectious foci, providi...

riginal Investigation  Health Policy March 19, 2025 Complex Sepsis Presentations, SEP-1 Compliance, and Outcomes Chanu Rhee, Sarah E. Train, Michael R. Filbin, et al JAMA Netw Open. 2025;8(3):e251100. doi:10.1001/jamanetworkopen.2025.1100 Key Points Question  Are sepsis presentations associated with Severe Sepsis and Septic Shock Management Bundle (SEP-1) compliance and mortality? Findings...

Original Investigation  January 15, 2025 Safety and Efficacy of Tranexamic Acid in General Surgery Lily J. Park, Maura Marcucci, Sandra N. Ofori, et al JAMA Surg. Published online January 15, 2025. doi:10.1001/jamasurg.2024.6048 Key Points Question  What is the safety and efficacy profile of prophylactic tranexamic acid (TXA) use in general surgery? Findings  In this substudy of a r...

Monitoring and ICP-Driven Therapies in TBI Using nICP Systems In ICU Tue, 4 Feb 2025 Intracranial hypertension after traumatic brain injury (TBI) leads to secondary brain damage, high mortality, and poor outcomes. Invasive intracranial pressure (ICP) monitoring using intraparenchymal or intraventricular systems is the gold standard for guiding TBI treatment. The Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) developed...

Research Safety of inpatient care in surgical settings: cohort study Antoine Duclos, Michelle L Frits, Christine Iannaccone, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-080480 (Published 13 November 2024)Cite this as: BMJ 2024;387:e080480 Abstract Objectives To estimate the frequency, severity, and preventability of adverse events associated with perioperative care, and to describe the setting and professions concerned. Design Mul...

Ventilatory Support for Asthma - An Overview of Critical Asthma Management In ICU Thu, 28 Nov 2024 ICU Management & Practice, Volume 24 - Issue 5, 2024 Critical asthma is relatively uncommon, with its incidence on the decline; however, it can require intensive care, including mechanical ventilation. This article provides an overview of critical asthma management. Critical asthma (CA) is an umbrella term embracing different definitions, all r...

Adverse Prehospital Events and Outcomes After TBI In ICU Tue, 4 Feb 2025 Traumatic brain injury (TBI) is a major global health issue, affecting approximately 70 million people annually. Severe TBI can lead to death or irreversible disability within hours. Emergency medical services (EMS) provide initial care guided by the Brain Trauma Foundation (BTF) guidelines, which focus on preventing secondary brain injury by managing hypoxia, hypotension, and hyp...

Original Investigation  Infectious Diseases March 14, 2025 Antimicrobial-Resistant Infections in Hospitalized Patients Hannah Wolford, Natalie L. McCarthy, James Baggs, et al JAMA Netw Open. 2025;8(3):e2462059. doi:10.1001/jamanetworkopen.2024.62059 Key Points Question  How has antimicrobial resistance changed from 2012 to 2022? Findings  In this cohort study of 7 158 139 culture...

Invited Commentary  March 10, 2025 Awake Prone Positioning in COVID-19—Is There a New Standard of Care? Michael A. Matthay, Katherine D. Wick, Narges Alipanah-Lechner JAMA Intern Med. Published online March 10, 2025. doi:10.1001/jamainternmed.2025.0021 In this issue of JAMA Internal Medicine, Luo et al1 presented compelling evidence for awake prone positioning for patients with acute hypoxemic respiratory failure from COVID-19. Thei...