CRITICAL CARE: ORIGINAL RESEARCH Normosol-R vs Lactated Ringers in the Critically Ill: A Randomized Trial Edward T. Qian, Ryan M. Brown, Karen E. Jackson, et al Chest 2025; 168: 336-345 Abstract Background Balanced crystalloid solutions may improve clinical outcomes compared with saline for some critically ill adults, but it is unclear whether differences in composition between balanced crystalloid solutions affect outcomes. Research Question Does ...

OPTPRESS: Targeting High Mean Arterial Pressure for Patients With Septic Shock  In Sepsis Tue, 3 Jun 2025 Sepsis is a serious global health issue, with septic shock carrying a high mortality rate (~38.5%). The optimal blood pressure target for managing septic shock remains unclear. Recent trials show that maintaining a mean arterial pressure (MAP) above 65 mmHg isn’t always beneficial, but higher targets (80–85 mmHg) may help patients with chronic...

Original Investigation  Occupational Health Smartwatch Use and Physician Well-Being: A Randomized Clinical Trial Liselotte N. Dyrbye, Colin P. West, Angelina R. Wilton, et al JAMA Netw Open Published Online: August 18, 2025 2025;8;(8):e2527275. doi:10.1001/jamanetworkopen.2025.27275 Key Points Question  Does wearing a smartwatch and having access to its physiological data (eg, sleep, ste...

Original Investigation  Health Policy Variation, Overlap, and Stability in Defining Safety Net Hospitals Paula Chatterjee, Joshua M. Liao, Kano Amagai, et al JAMA Netw Open 2025;8;(7):e2523923. doi:10.1001/jamanetworkopen.2025.23923 Key Points Question  To what extent do different definitions for safety net hospitals overlap, change over time, and represent similar types of facilities? Findings &n...

Editor's Note  What if Readmission Prevents Death?—The Challenge of Composite Outcomes Deborah Grady, Raegan W. Durant, Timothy S. Anderson JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3709 Composite outcomes, which combine several different events into a single outcome, are frequently used in clinical trials. Clinical trials testing transition of care interventions often measure distinct outcomes such as readmissio...

Original Investigation  Proactive Telehealth-Based Sepsis Transition and Recovery Support, Hospital Readmission, and Mortality: A Randomized Clinical Trial Stephanie Parks Taylor, Tara Eaton, Aleta Rios, et al JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3699 Key Points Question  Does a multicomponent, navigator-led sepsis transition and recovery (STAR) progr...

#EA25: Managing the Bloody AirwayIn ICUMon, 26 May 2025 Difficult airway management is a core competency for any anaesthesiologist and can often mean the difference between life and death. Among the most complex and high-risk scenarios is the bloody airway, where active bleeding significantly impairs visibility and complicates even standard difficult airway techniques. Failure to control bleeding in the airway is a major contributor to airway-related mortality. ...

Research Letter  Trends in Utilization of Microaxial Flow Pump and Intra-Aortic Balloon Pump Across 3 Countries Dennis T. Ko, Sharon Ayayo, Amitava Banerjee, et al JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3881 Rising health care spending is threatening the sustainability of health systems in many high-income countries.1While health technology assessment (HTA) is used ...

Invited Commentary  Antibiotic Prophylaxis in Variceal Hemorrhage—Time to Stop? Catherine Mezzacappa, Guadalupe Garcia-Tsao JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3841 In their systematic review and bayesian meta-analysis published in this issue of JAMA Internal Medicine, Prosty et al1 assess the evidence supporting the universally recommended practice of administering prophylactic broad-spectrum ant...

Original Investigation  Global Burden of Disease Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021 GBD 2021 Global Subarachnoid Hemorrhage Risk Factors Collaborators JAMA Neurol 2025;82;(8):765-787. doi:10.1001/jamaneurol.2025.1522 Key Points Question  What is the global burden of nontraumatic subarachnoid hemorrhage (SAH)? Findings  Results of this cross-...