C-EASIE Trial: Early Administration of Vitamin C in Sepsis or Septic Shock In Sepsis Mon, 28 Apr 2025 Sepsis and septic shock represent critical conditions frequently encountered in emergency medicine, carrying significant risks of morbidity and mortality. Vitamin C has been proposed as a potential therapeutic agent due to its antioxidant, anti-inflammatory, and immunomodulatory properties.  The C-EASIE trial was conducted to evaluate whether e...

JOURNAL ARTICLE Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes: How Much Does Getting It Right With Empiric Antibiotics Matter? Jonathan D Baghdadi, Katherine E Goodman, Laurence S Magder, et al Clin Infect Dis 2025; 80: 949-958 https://doi.org/10.1093/cid/ciaf039 Abstract Background Clinicians often start unnecessarily broad-spectrum empiric gram-negative antibiotics out of the concern that delayi...

Timing of anticoagulation after ischaemic stroke and atrial fibrillation: better swift than sorry Wendy C Ziai, Georgios Tsivgoulis Lancet Available online 23 June 2025 https://doi.org/10.1016/S0140-6736(25)00676-2 Non-valvular atrial fibrillation accounts for 13–26% of acute ischaemic strokes.1 Direct oral anticoagulants (DOACs) are highly effective in reducing the risk of ischaemic stroke with significantly lower rates of intracranial haemorrhage compar...

Research Letter  Randomized Experiment of Recruitment Letter Design to Maximize Clinical Trial Enrollment Niklas Dyrby Johansen, David Preiss, Marion Mafham, et al JAMA Published Online: June 25, 2025 doi: 10.1001/jama.2025.9170 Most new medical therapies only offer small to moderate benefits above high-level standard care and require increasingly large trials to demonstrate efficacy in light of generally de...

Burden of Brain Tissue Hypoxia, Metabolic Dysfunction in SAH  In ICU Mon, 28 Apr 2025 Non-traumatic subarachnoid haemorrhage (SAH) is a significant cause of death and disability globally, with an incidence of around 6 per 100,000 person-years. The initial treatment focuses on early aneurysm repair to prevent re-bleeding and reduce early brain injury risk. Management also addresses secondary brain injuries, including hydrocephalus, elevated intracr...

JOURNAL ARTICLE Performance of Diagnostic Algorithms in Patients With Invasive Pulmonary Aspergillosis Stefan Hatzl, Christina Geiger, Lisa Kriegl, et al Clin Infect Dis 2025: 80: 1080-1087 https://doi.org/10.1093/cid/ciae633 Abstract Background Invasive pulmonary aspergillosis (IPA), once limited to immunocompromised patients, is now a severe complication in critically ill ICU patients without classic risk factors. Due to the difficulty of ...

Original Investigation  AI in Medicine Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning Gregory Holste, Evangelos K. Oikonomou, Márton Tokodi, et al JAMA Published Online: June 23, 2025 doi: 10.1001/jama.2025.8731 Key Points Question  Can artificial intelligence (AI) fully automate echocardiogram interpretation? Findings  This study reports the dev...

Non-Burn Dermatological Emergencies in Critical Care In ICU Tue, 22 Apr 2025 Non-burn dermatologic emergencies, although less common than burn injuries, are associated with high morbidity and mortality due to the extensive loss of the skin barrier. These conditions often mimic burn-related pathophysiology and demand urgent, multidisciplinary care. Optimal outcomes are typically achieved at specialised burn centres, but limited availability means that i...

Original Investigation  Emergency Medicine Serious Illness Conversations in the Emergency Department for Older Adults With Advanced Illnesses: A Randomized Clinical Trial Kei Ouchi, Susan D. Block, Dorene M. Rentz, et al JAMA Netw Open 2025;8;(6):e2516582. doi:10.1001/jamanetworkopen.2025.16582 Key Points Question  Does an emergency department (ED)–based intervention to discuss serious illness care goals ...

Research Letter  Continuous Medical Knowledge Assessment Progress Report Score and Hospitalized Patient Outcomes Bradley M. Gray, Jonathan L. Vandergrift, Rebecca S. Lipner, et al JAMA Intern Med Published Online: June 16, 2025 doi: 10.1001/jamainternmed.2025.1730 The American Board of Internal Medicine started offering a Longitudinal Knowledge Assessment (LKA) in 2022 as an alternative to the 10-year long-f...