Original Investigation September 3, 2019 N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial Lewis J. Radonovich Jr, Michael S. Simberkoff, Mary T. Bessesen, et al JAMA. 2019;322(9):824-833. doi:10.1001/jama.2019.11645 Abstract Importance 背景 Clinical studies have been inconclusive about the effectiveness of N95 respirators and medical m...

ICU Management & Practice, Volume 19 - Issue 2, 2019 Use of sedation and controlled paralysis in ICU patients with ARDS According to a National Institutes of Health sponsored clinical trial that was conducted at several North American hospitals and was led by clinician-scientists at the University of Pittsburgh and University of Colorado schools of medicine, reversibly paralysing and sedating hospitalised patients with severe breathing problems does not pro...

Original Investigation August 27, 2019 Association Between Educational Attainment and Causes of Death Among White and Black US Adults, 2010-2017 Isaac Sasson, Mark D. Hayward JAMA. 2019;322(8):756-763. doi:10.1001/jama.2019.11330 Abstract Importance 背景 There are substantial and increasing educational differences in US adult life expectancy. To reduce social inequalities in mortality, it is important to understand...

ARTICLES| VOLUME 7, ISSUE 8, P699-709, AUGUST 01, 2019 Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial Pradeesh Sivapalan, Therese S Lapperre, Julie Janner, et al. Lancet Respir Med 2019; 7: 699-709 DOI:https://doi.org/10.1016/S2213-2600(19)30176-6 Summary Background 背景 Treatment with systemic corticost...

ICU Management & Practice, Volume 18 - Issue 3, 2018 Fluids in shock Fluid management during shock from physiology to bedside. Shock is a common life-threatening, generalised form of acute circulatory failure in critically ill patients, which is usually managed by infusing fluids to increase cardiac output and supply the systemic oxygen request. International guidelines recommend use of an aggressive fluid resuscitation in the early phases of shock. In t...

Liberation from Mechanical Ventilation Over 1 million people patients throughout the world receive mechanical ventilation for acute respiratory failure. The management of these critically ill patients and liberating them from invasive ventilation is one of the most important decisions clinicians have to make. Liberation from ventilation is also a major dilemma for clinicians because any error could result in significant harm to the patient. Premature or failed atte...

ICU Management & Practice, Volume 18 - Issue 4, 2018 Abdominal point-of-care ultrasound in critical care The secrets of the abdomen Overview of abdominal point-of-care ultrasound use in the ICU, potential diagnoses and findings common to the critical care patient population. The use of point-of-care ultrasound (POCUS) in critical care as a diagnostic and monitoring tool is rapidly expanding. While its role in cardiovascular and respiratory assessment ...

ORIGINAL ARTICLE Ambient Particulate Air Pollution and Daily Mortality in 652 Cities Cong Liu, Renjie Chen, Francesco Sera, et al Abstract BACKGROUND 背景 The systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias. 由于模型特征的差异以及发表偏倚，系统评估大气污染的时间序列研究受到挑战。 METHODS 方法学 We evaluated the associations of inhalable particulate...

ICU Management & Practice, Volume 18 - Issue 1, 2018 “Simulate, or not to simulate?” Evolution in medicine and the anaesthesia context.  A brief discussion about the importance and the state of the art of simulation in anaesthesia and intensive care medicine. Training in simulation plays a key role in complex systems such as aviation and the nuclear industry, to investigate predictable errors that lead to adverse outcomes. The advancement made by...

ORIGINAL ARTICLE Effects of Serelaxin in Patients with Acute Heart Failure Marco Metra, John R. Teerlink, Gad Cotter, et al N Engl J Med 2019; 381:716-726DOI: 10.1056/NEJMoa1801291 Abstract BACKGROUND 背景 Serelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in b...