Research Letter | April 22, 2020 Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection Giacomo Spinato, Cristoforo Fabbris,  Jerry Polesel, et al JAMA. 2020;323(20):2089-2090. doi:10.1001/jama.2020.6771 Since December 2019, a pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally.1 A spectrum of disease severity has been reported, with m...

Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report RECOVERY Collaborative Group ABSTRACT Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death. Methods: The Randomised Evaluation of COVID-19 therapy (RECOVERY) trial is a randomized, controlled, open-label, adaptive, platform ...

Original Investigation June 3, 2020 Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial Ling Li, Wei Zhang, Yu Hu, et al JAMA. Published online June 3, 2020. doi:10.1001/jama.2020.10044 Abstract Importance Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from rando...

Original Investigation Caring for the Critically Ill Patient Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-analysis Bruno L. Ferreyro, Federico Angriman, Laveena Munshi, et al JAMA. Published online June 4, 2020. doi:10.1001/jama.2020.9524 Abstract Importance Treatment with noninvasive oxygenation strategies such as noninvasive ventilation and hi...

ARTICLES| VOLUME 395, ISSUE 10241, P1927-1936, JUNE 20, 2020 Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial The HALT-IT Trial Collaborators Lancet Published: June 20, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)30848-5 Summary Background Tranexamic acid reduces surgical bleeding and...

Where Are the Most Effective Anti-COVID-19 Strategies? The majority of countries have introduced at least some nation-wide measures aimed at containing the spread of the novel coronavirus pandemic. The measures include stopping/limiting international and domestic movement, closing educational facilities, banning public gatherings or announcing quarantine, to name a few. You may also like: COVID-19: Quarantine Measures, Laws and Limits As ISGlobal&n...

Oxford University News Release EMBARGOED UNTIL 16 June 2020, 13:00 (UK Time)  Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 In March 2020, the RECOVERY (Randomised Evaluation of COVid-19 thERapY) trial was established as a randomised clinical trial to test a range of potential treatments for COVID-19, including low-dose dexamethasone (a steroid treatment). Over 11,500 patients h...

Hydroxychloroquine and QT Prolongation As the healthcare community attempts to deal with the coronavirus disease (COVID-19), there is an intense effort to develop an effective treatment strategy. While research on the development of a vaccine continues, clinicians have been forced to use treatments that lack robust clinical evidence. With many patients succumbing to acute respiratory distress syndrome, multi-organ failure, severe pneumonia, and a variety of cardiac com...

News Covid-19: Experts question guidance to reuse PPE Abi Rimmer BMJ 2020; 369: m1577 doi: https://doi.org/10.1136/bmj.m1577 (Published 20 April 2020) Doctors have expressed concern over new guidance from Public Health England that recommends reusing personal protective equipment in the face of shortages.1 The guidance, which also recommends alternatives for unavailable equipment, has been seen as an admission by the government of the PPE shortages facing h...

Association of ACE Inhibitors and COVID-19 Severity or Risk of Death The COVID-19 pandemic has resulted in a significant number of deaths worldwide. Clinicians are still unclear as to who might be more susceptible to the infection and the factors associated with increased mortality. Laboratory data have shown that the angiotensin-converting enzyme-2 (ACE-2) serves as the receptor for severe acute respiratory syndrome coronavirus to gain entry into airway cells. Thus, a...