ICU Management & Practice, Volume 20 - Issue 4, 2020 Treatment of Catecholamine Refractory Hypotension in Septic Shock: Beyond First Line Vasopressor Hypotension during septic shock is a strong indicator of patient outcome and mortality. Arginine vasopressin is a naturally produced human hormone with vasoconstriction effect via V1 receptor activation and a short 5-20 minutes half-life and is recommended by the Surviving Sepsis Campaign guidelines to be adde...

ORIGINAL ARTICLE Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 The REMAP-CAP Investigators N Engl J Med 2021; 384:1491-1502DOI: 10.1056/NEJMoa2100433 Abstract BACKGROUND The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adul...

Prevalence and Risk Factors for Delirium in COVID-19 ICU Patients According to findings from a large study, COVID-19 patients admitted to the ICU in the early months of the pandemic had a higher burden of delirium and coma than is typically found in patients with acute respiratory failure. The findings are published in The Lancet Respiratory Medicine. Study investigators tracked the incidence of delirium and coma in 2088 COVID-19 patients admitted in the ICU be...

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published:May 14, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00897-7 Summary Background Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to ho...

ARTICLES| VOLUME 397, ISSUE 10281, P1293-1300, APRIL 03, 2021 Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial Stéphane Gaudry, David Hajage, Laurent Martin-Lefevre, et al Lancet 2021; 397: 1293-1300 Summary Background Delaying renal replacement therapy (RRT) for some time in critically ill patients with severe acu...

Original Investigation May 6, 2021 Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers Yoel Angel, Avishay Spitzer, Oryan Henig, et al JAMA. Published online May 6, 2021. doi:10.1001/jama.2021.7152 Abstract Importance Randomized clinical trials have provided estimates of the effectiveness of the BNT162b2 vaccine against symptomatic SARS-CoV-2 infection,...

ARTICLES| VOLUME 397, ISSUE 10283, P1459-1469, APRIL 17, 2021 SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN) Victoria Jane Hall, Sarah Foulkes, Andre Charlett, et al Lancet 2021; 379: 1459-1469 DOI:https://doi.org/10.1016/S0140-6736(21)00675-9 Summary Background Increased understanding of whether individuals who have r...

Improving Survival of Critical Care Patients With COVID-19 in England Data from the UK suggests that there has been an improvement in the survival of hospitalised patients with COVID-19 in recent months. Case-fatality rate of hospitalised patients declined from 6% in April 2020 to 1.5% by July 2020.  A possible explanation for this shift may be the fact that there has been a shift in the demographics of people admitted with COVID-19. Patients are now younger an...

CORRESPONDENCE|ONLINE FIRST Thromboembolism and the Oxford–AstraZeneca COVID-19 vaccine: side-effect or coincidence? Søren Dinesen Østergaard, Morten Schmidt, Erzsébet Horváth-Puhó, et al Lancet Published: March 30, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00762-5 By mid March, 2021, vaccination against COVID-19 using the ChAdOx1 nCoV-19 (AZD1222) vaccine from Oxford–AstraZeneca1, 2was paused in a number of European countries due to reports of thrombo...

ORIGINAL ARTICLE A Microbiota-Directed Food Intervention for Undernourished Children Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, et al N Engl J Med April 7, 2021DOI: 10.1056/NEJMoa2023294 BACKGROUND More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed developme...