ICU Management & Practice, Volume 20 - Issue 3, 2020 Lessons from COVID-19: ICU Preparedness, Ethical Issues and Digital Congresses Jean-Louis Vincent is a Consultant in the Department of Intensive Care at Erasme University Hospital in Brussels and a Professor of Intensive Care at the Université libre de Bruxelles.He is the editor-in-chief of ICU Management & Practice, Critical Care, and Current Opinion in Critical Care and member of the editorial board...

Original | Published: 06 September 2020 Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial Robert M. Kacmarek, Jesús Villar, Dácil Parrilla, et al Intensive Care Med 2020 Abstract Purpose 背景 We hypothesized that neurally adjusted ventilatory assist (NAVA) compared to conventional lung-protective mechanical ventilation (MV) decreases duration of MV and mortality in patients with acute respiratory failure (AR...

ICU Management & Practice, Volume 20 - Issue 3, 2020 Lessons From the “Very Old Intensive Care Patients” (VIP) Project An overview of the VIP project that studies a subgroup of patients ≥ 80 years, the oldest old, since both ICU mortality and morbidity are increased with advanced age. During the last 10 years, we have observed an increased interest in research into our oldest intensive care patients. This is brought forward with the expectation...

ORIGINAL ARTICLE Interferon Beta-1b and Lopinavir–Ritonavir for Middle East Respiratory Syndrome Yaseen M. Arabi, Ayed Y. Asiri, Abdullah M. Assiri, et al N Engl J Med October 7, 2020DOI: 10.1056/NEJMoa2015294 Abstract 摘要 BACKGROUND 背景 Whether combined treatment with recombinant interferon beta-1b and lopinavir–ritonavir reduces mortality among patients hospitalized with Middle East respiratory syndrome (MERS) is unclear. 重组beta-1b干扰素与克立芝...

ARTICLES|ONLINE FIRST Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial Remo H M Furtado, Otavio Berwanger, Henrique A Fonseca, et al Lancet Published:September 04, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31862-6 Summary 摘要 Background 背景 The efficacy and safety of azithromycin in the treatmen...

ARTICLES|ONLINE FIRST Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial Toby Richards, Ravishankar Rao Baikady, Ben Clevenger, et al Lancet Published:September 04, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31539-7 Summary 摘要 Background 背景 Preoperative anaemia affects a high proportion of patients undergoing major elective surgery and is associated with poor outc...

COVID-19 and readjusting clinical trials The COVID-19 pandemic has disrupted clinical trials worldwide, with long-lasting effects on medical science. Aaron van Dorn reports. Lancet 2020; 396: 523-524 The COVID-19 pandemic has disrupted clinical trials worldwide, with long-lasting effects on medical science. Aaron van Dorn reports.The COVID-19 pandemic has created massive disruptions to clinical trial research across the world. As in other aspects of life, the vir...

HealthManagement, Volume 20 - Issue 5, 2020 COVID-19 Antibody Testing – Why it Matters and Factors to Consider As we move into the next phase of the COVID-19 pandemic, there will be a need to test a broad strata of population, much more than what molecular tests can handle. The solution lies with serological tests. As the world continues the fight against COVID-19, healthcare executives are in an uncomfortable position – having to make critical decisions wit...

PulmCrit – Splitting ventilators to provide titrated support to a large group of patients March 15, 2020 by Josh Farkas COVID-19 might out-strip the number of mechanical ventilators available to us.  This has led to interest in using a single ventilator to support multiple patients.  This post will review the theory and evidence regarding this (with the admission that I don’t have experience with this).  basic principles Bedrock principle: ...

COVID-19: Lessons to Learn from Public Discourse Regarding Hydroxychloroquine The COVID-19 pandemic has affected all aspects of our lives, including the economy, healthcare and scientific research. In the race to find effective and safe treatment for coronavirus disease, there has been a significant increase in scientific communication. However, the quality of this communication remains questionable. Preprints are not  peer-reviewed even though they are being...