ARTICLES|ONLINE FIRST Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial Alasdair P S Munro, Shuo Feng, Leila Janani, et al Lancet Infect Dis Published:May 09, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00271-7 Summary Background Some high-in...

ICU-Related Loss of Quality of Life After COVID-19 COVID-19 has had a significant impact on the number of hospital admissions, including many patients presenting acute respiratory failure. Approximately 15% of hospitalised COVID-19 patients require ICU admission.  It is well established that the physical and psychological impact of an ICU stay on patients can be quite significant and prolonged. Many ICU survivors report functional disability that can persis...

ARTICLES| VOLUME 399, ISSUE 10340, P2047-2064, MAY 28, 2022 Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis You Li, Xin Wang, Dianna M Blau, et al Lancet 2022; 399: 2047-2064 Summary Background Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infection in young...

ARTICLES|ONLINE FIRST Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study Edward Burn, Talita Duarte-Salles, Sergio Fernandez-Bertolin, et al Lancet Infect Dis Published:May 13, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00223-7 Summary Background There are few data on the incidence of thrombosis among COVID-19 cases, with most research concentrated on hospitalised patients. We aimed to estimate the incid...

Original Investigation May 15, 2022 Effect of Robot-Assisted Radical Cystectomy With Intracorporeal Urinary Diversion vs Open Radical Cystectomy on 90-Day Morbidity and Mortality Among Patients With Bladder Cancer: A Randomized Clinical Trial James W. F. Catto, Pramit Khetrapal, Federico Ricciardi, et al JAMA. Published online May 15, 2022. doi:10.1001/jama.2022.7393 Key Points Question  Does robot-assisted surgery improve periopera...

CORRESPONDENCE Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults Patrick E. Brown, Sze Hang Fu, Aiyush Bansal, et al N Engl J Med May 18, 2022DOI: 10.1056/NEJMc2202879 TO THE EDITOR: The incidence of the omicron BA.1/1.1 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which rapidly spread worldwide even among vaccinated persons, is incompletely defined.1 We quantified the incidence of SARS-CoV-2 infection d...

#ISICEM22: Vasodilatory Choice and Timing An article released in conjunction with the Intensive Care & Emergency Medicine (ISICEM) Congress helps clinicians understand the choice and timing of vasopressors in vasodilatory shock. It is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Vasodilatory shock is one of the most common forms encountered in patients admitted to the ICU. The predominant aetiology of th...

ARTICLES|ONLINE FIRST Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials National Institute of Health Research Unit on Global Surgery Lancet Infect Dis Published:May 26, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00133-5 Summary Background WHO and the UK's National Institute for Health and Care Excellence recommen...

JAMA Clinical Guidelines Synopsis May 16, 2022 Antithrombotic Therapy for Venous Thromboembolism Christopher D. Jackson, Adam S. Cifu, Desirée C. Burroughs-Ray JAMA. Published online May 16, 2022. doi:10.1001/jama.2022.7325 Guideline title Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report Developer and funding source American College of Chest Physicians Release date August 2...

ORIGINAL ARTICLE Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 Yair Goldberg, Micha Mandel, Yinon M. Bar-On, et al N Engl J Med May 25, 2022DOI: 10.1056/NEJMoa2118946 Abstract BACKGROUND Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides natural immunity against reinfection. Recent studies have shown waning of the immunity provided by the BNT162b2 vaccine. The time course of natural and hybrid immuni...