CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 2, P392-406, FEBRUARY 01, 2022 Effects of Compliance With the Early Management Bundle (SEP-1) on Mortality Changes Among Medicare Beneficiaries With Sepsis: A Propensity Score Matched Cohort Study Sean R. Townsend, Gary S. Phillips, Reena Duseja, et al Chest 2022; 161: 392-406 Background US hospitals have reported compliance with the SEP-1 quality measure to Medicare since 2015. Finding an a...

COMMENT| VOLUME 10, ISSUE 4, P319-320, APRIL 01, 2022 Bringing biological ARDS phenotypes to the bedside with machine-learning-based classifiers Stephen Whebell, J Zhang Lancet Respir Med Published:January 10, 2022 DOI:https://doi.org/10.1016/S2213-2600(21)00492-6 The identification of distinct phenotypes within heterogeneous disease states is a key component of personalised medicine, enabling enrichment of clinical trials, better prognostica...

#ISICEM22: HFNO Alone Versus HFNO Alternated With NIV (FLORALI-IM Study) Non-invasive ventilation (NIV) is recommended for immunocompromised patients with acute respiratory failure in the ICU. However, it can have harmful effects. High-flow nasal oxygen (HFNO) alone could be an alternative strategy to reduce mortality.  The HFNC Alone or Associated With NIV for Immunocompromised Patients Admitted to ICU for Acute Respiratory Failure (FLORALI-IM) study was conduc...

ARTICLES|ONLINE FIRST The first WHO global survey on infection prevention and control in health-care facilities Sara Tomczyk, Anthony Twyman, Marlieke E A de Kraker, et al Lancet Infect Dis Published: February 21, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00809-4 Summary Background WHO core components for infection prevention and control (IPC) are important building blocks for effective IPC programmes. To our knowledge, we did the first WHO globa...

CORRESPONDENCE|ONLINE FIRST Shanghai's life-saving efforts against the current omicron wave of the COVID-19 pandemic Xinxin Zhang, Wenhong Zhang, Saijuan Chen Lancet Published:May 06, 2022 DOI: https://doi.org/10.1016/S0140-6736(22)00838-8 In late February, 2022, a wave of SARS-CoV-2 infection rapidly appeared in Shanghai, China. According to the Shanghai Municipal Health Commission, as of May 4, 2022, 601 942 cases have been identified, including 547 056 a...

ARTICLES|ONLINE FIRST High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial Rémi Coudroy, Jean-Pierre Frat, Stephan Ehrmann, et al Lancet Respir Med Published:March 21, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00096-0 Summary Background Although non-invasive ventilation (NIV) is recommended for immunocompromised patients...

ICU Management & Practice, Volume 22 - Issue 1, 2022 Diagnostic and Prognostic Value of Estimated Plasma Volume Status An overview of estimated plasma volume (ePVS), recent evidence supporting the association of ePVS with clinical congestion and whether it can help improve outcomes in patients with heart failure (HF). Plasma volume (PV) is the level of intravascular fluid minus the red blood cells, white blood cells and platelets. PV in heart failure (HF...

ARTICLES|ONLINE FIRST Implementation of hand hygiene in health-care facilities: results from the WHO Hand Hygiene Self-Assessment Framework global survey 2019 Marlieke E A de Kraker, Ermira Tartari, Sara Tomczyk, et al Lancet Infect Dis Published: February 21, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00618-6 Summary Background Hand hygiene is at the core of effective infection prevention and control (IPC) programmes. 10 years after the developme...

Research Letter April 8, 2022 Systemic Corticosteroid Use for COVID-19 in US Outpatient Settings From April 2020 to August 2021 Marie C. Bradley, Silvia Perez-Vilar, Yoganand Chillarige, et al JAMA. Published online April 8, 2022. doi:10.1001/jama.2022.4877 In June 2020, preliminary results for the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial conducted in the UK indicated benefit from dexamethasone in severely ill hospitalized pati...

COMMENT| VOLUME 10, ISSUE 4, P314-315, APRIL 01, 2022 Baricitinib for patients with severe COVID-19—time to change the standard of care? Alexander Supady, Robert Zeiser Lancet Respir Med 2022; 10: 314-315 Mortality is high among patients with severe COVID-19 who require invasive mechanical ventilation (IMV) or extracorporeal membrane oxygenation (ECMO).1, 2 Therefore, further specific treatment options for these patients are urgently needed. ...