ORIGINAL ARTICLE Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants Natasha B. Halasa, Samantha M. Olson, Mary A. Staat, et al N Engl J Med 2022; 387:109-119DOI: 10.1056/NEJMoa2204399 Abstract BACKGROUND Infants younger than 6 months of age are at high risk for complications of coronavirus disease 2019 (Covid-19) and are not eligible for vaccination. Transplacental transfer of antibodies against severe acute respiratory syndrome ...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Sedation, Analgesia and Respiratory Drive in Mechanically Ventilated Adults An overview of the cardiovascular and respiratory effects of sedative agents commonly used in the ICU, emerging concepts of mechanical ventilation induced injury to the respiratory muscles and evolving concepts for sedation monitoring and sedation minimisation to achieve the goal of expeditious liberation from mechanical ventilati...

Research Letter  June 29, 2022 Internet Searches for Abortion Medications Following the Leaked Supreme Court of the United States Draft Ruling Adam Poliak, Nora Satybaldiyeva, Steffanie A. Strathdee, et al JAMA Intern Med. Published online June 29, 2022. doi:10.1001/jamainternmed.2022.2998 On May 2, 2022, a draft Supreme Court of the United States (SCOTUS) majority opinion was leaked,1 foreshadowing the decision to overturn the 1973 ...

PULMONARY VASCULAR: GUIDELINES AND CONSENSUS STATEMENTS| VOLUME 162, ISSUE 1, P213-225, JULY 01, 2022 Thromboprophylaxis in Patients With COVID-19: A Brief Update to the CHEST Guideline and Expert Panel Report Lisa K. Moores, Tobias Tritschler, Shari Brosnahan, et al Chest 2022; 162: 213-225 Published:February 12, 2022 DOI:https://doi.org/10.1016/j.chest.2022.02.006 Background Patients hospitalized with COVID-19 often exhibit markers of a ...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Nutrition Monitoring and Patient Data Management Systems An overview of nutritional targets and their impact on critically ill patients and the need to use a systematic approach to nutritional support for optimal patient outcomes. Critically ill patients are often hypermetabolic and catabolic and are at a higher risk of underfeeding. Nutritional support for these patients can prevent energy deficits an...

Research Letter  July 5, 2022 Leading Causes of Death in the US During the COVID-19 Pandemic, March 2020 to October 2021 Meredith S. Shiels, Anika T. Haque, Amy Berrington de González, et al JAMA Intern Med. Published online July 5, 2022. doi:10.1001/jamainternmed.2022.2476 In 2020, heart disease and cancer were the leading causes of death in the US, accounting for 1.29 million deaths, followed by COVID-19, accounting for 350 000 deaths.1-3&n...

Original Investigation  July 5, 2022 Association of the “Weekend Warrior” and Other Leisure-time Physical Activity Patterns With All-Cause and Cause-Specific Mortality: A Nationwide Cohort Study Mauricio dos Santos, Gerson Ferrari, Dong Hoon Lee, et al JAMA Intern Med. Published online July 5, 2022. doi:10.1001/jamainternmed.2022.2488 Key Points Question  Does performing the recommended levels of weekly physical activity in 1 to ...

Research Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital: systematic review and network meta-analysis Ruben J Eck, Tessa Elling, Alex J Sutton, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070022 (Published 04 July 2022)Cite this as: BMJ 2022;378:e070022 Abstract Objective To assess the benefits and harms of different types and doses of anticoagulant drugs for the prevention of venous thromboembolism ...

Original Investigation  July 5, 2022 High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure: The COVIDICUS Randomized Clinical Trial Lila Bouadma, Armand Mekontso-Dessap, Charles Burdet, et al JAMA Intern Med. Published online July 5, 2022. doi:10.1001/jamainternmed.2022.2168 Key Points Question  What are the effects of high-dose vs low-dose d...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Pain Assessment in Critical Illness This narrative paper reports the practical assessment of pain in critically ill (ICU) patients, based on current evidence and guidelines. Introduction Pain is one of the top stressful symptoms experienced by critically ill patients hospitalised in intensive care units (ICU) (Chanques et al. 2015). This is because critical pathologies are often severely painful (i....