Editorial  Caring for the Critically Ill Patient Precision Therapy for Sepsis: The End of the Beginning? Derek C. Angus JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.24099 Sepsis is a macabre dance between host and pathogen.1 With development of germ theory by Lister, Semmelweis, Pasteur, and Koch, pathogen eradication was the focus. Only in recent decades, with observations by Roger Bone2 and others that patients succumbed to sepsi...

Original Investigation  Caring for the Critically Ill Patient Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial Evangelos J. Giamarellos-Bourboulis, Antigone Kotsaki, Ioanna Kotsamidi, et al JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.24175 Key Points Question  Does immunotherapy tailored to the type of immune dysregulation improve outcomes among patients with sepsis? Findi...

Early Mobilisation and Rehabilitation Protocol and Outcomes in Trauma In ICU Wed, 6 Aug 2025 Traumatic injury remains a leading cause of death and disability globally, though mortality has decreased due to advances in surgery and centralised trauma care. Consequently, long-term outcomes like social reintegration have gained importance.  Early mobilisation and rehabilitation in the ICU are known to improve physical function, reduce ICU and hospi...

ARTICLES Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Causes of Death Collaborators Lancet 2025; 406: 1811-1872 DOI: 10.1016/S0140-6736(25)01330-3 External Link Summary Background Comprehensive, comparable, and timely estimates of demographic metrics—including life expectancy and age-specific mortality...

Articles Duration of the serological response and effectiveness of the inactivated influenza vaccine in healthy adults aged 18–65 years: a systematic review and meta-analysis Joshua Nazareth, Neyme Veli, Daniel Pan, et al Lancet Microbe Available online 7 October 2025 https://doi.org/10.1016/j.lanmic.2025.101136 Summary Background The protection provided by the inactivated influenza vaccine (IIV) in adults can wane during a single influenza season. We ai...

Rationale for Enteral Nutrition in Critically Ill Adults In ICU Tue, 22 Jul 2025 Mechanically ventilated adults cannot eat by mouth, making enteral nutrition (EN) a major part of supportive care. Over the past 20 years, research has improved understanding of critical illness phases, body responses, and the role of EN in critically ill adults. A recent narrative review provides an overview of EN by outlining the phases of critical illness, explaining...

Articles Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II): a multiregional, seasonal, hospital-based, cluster-randomised, controlled trial in China Craig S Anderson, Chang Hua, Zhiyan Wang, et al Lancet 2025; 406: 1020-1031 https://doi.org/10.1016/S0140-6736(25)01485-0 Summary Background Influenza vaccination is widely recommended to prevent death and serious illness in vulnerable people, including those with ...

ONLINE FIRST (FREE ACCESS) THE BRAIN IN THE LINE OF FIRE Editorial Neurotoxicity of sedative drugs: a matter of concern in adults?Landoni G., Kotani Y. & Lomivorotov V. Maintenance and resuscitation fluids for brain injury: keep them salty and not too sweet but mind the kidneyvan Regenmortel N., van der Jagt M. Transfusion targets after acute brain injury: the view of the trialistsTaccone, F. S., English, S. W. & Turgeon, A. F.  OPEN ACCESS ~ Wha...

Original Investigation  Pediatrics Antenatal Corticosteroids and Infectious Diseases Throughout Childhood Fabienne Decrue, Emily M. Frier, Chun Lin, et al JAMA Netw Open 2025;8;(10):e2536809. doi:10.1001/jamanetworkopen.2025.36809 Key Points Question  Is maternal antenatal corticosteroid treatment associated with increased susceptibility for respiratory and nonrespiratory infections in offspring from chil...

IsoCOMFORT: Inhaled Isoflurane for Sedation of Mechanically Ventilated Children  In ICU Tue, 22 Jul 2025 Current sedation for mechanically ventilated paediatric patients typically involves intravenous midazolam combined with opioids, and sometimes ketamine or α2-adrenergic agonists like clonidine or dexmedetomidine. Midazolam is the only drug officially approved for continuous sedation in this setting but is linked to prolonged wake-up times, with...