Research Letter  July 5, 2022 Leading Causes of Death in the US During the COVID-19 Pandemic, March 2020 to October 2021 Meredith S. Shiels, Anika T. Haque, Amy Berrington de González, et al JAMA Intern Med. Published online July 5, 2022. doi:10.1001/jamainternmed.2022.2476 In 2020, heart disease and cancer were the leading causes of death in the US, accounting for 1.29 million deaths, followed by COVID-19, accounting for 350 000 deaths.1-3&n...

Original Investigation  July 5, 2022 Association of the “Weekend Warrior” and Other Leisure-time Physical Activity Patterns With All-Cause and Cause-Specific Mortality: A Nationwide Cohort Study Mauricio dos Santos, Gerson Ferrari, Dong Hoon Lee, et al JAMA Intern Med. Published online July 5, 2022. doi:10.1001/jamainternmed.2022.2488 Key Points Question  Does performing the recommended levels of weekly physical activity in 1 to ...

Research Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital: systematic review and network meta-analysis Ruben J Eck, Tessa Elling, Alex J Sutton, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070022 (Published 04 July 2022)Cite this as: BMJ 2022;378:e070022 Abstract Objective To assess the benefits and harms of different types and doses of anticoagulant drugs for the prevention of venous thromboembolism ...

Original Investigation  July 5, 2022 High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure: The COVIDICUS Randomized Clinical Trial Lila Bouadma, Armand Mekontso-Dessap, Charles Burdet, et al JAMA Intern Med. Published online July 5, 2022. doi:10.1001/jamainternmed.2022.2168 Key Points Question  What are the effects of high-dose vs low-dose d...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Pain Assessment in Critical Illness This narrative paper reports the practical assessment of pain in critically ill (ICU) patients, based on current evidence and guidelines. Introduction Pain is one of the top stressful symptoms experienced by critically ill patients hospitalised in intensive care units (ICU) (Chanques et al. 2015). This is because critical pathologies are often severely painful (i....

Original Investigation  June 13, 2022 Mortality Among Patients Undergoing Blood Transfusion in Relation to Donor Sex and Parity: A Natural Experiment Jingcheng Zhao, Arvid Sjölander, Gustaf Edgren JAMA Intern Med. 2022;182(7):747-756. doi:10.1001/jamainternmed.2022.2115 Key Points Question  Does blood donor sex or parity affect mortality of patients undergoing transfusion? Findings  In this nationwide cohort study involving...

Infectious Diseases Society of America Guidance on the Treatment of AmpC β-Lactamase–Producing Enterobacterales, Carbapenem-Resistant Acinetobacter baumannii, and Stenotrophomonas maltophilia Infections Pranita D. Tamma, Samuel L. Aitken, Robert A. Bonomo, et al Clinical Infectious Diseases 2022; 74(12): 2089-2114 AMPC Β-LACTAMASE–PRODUCING ENTEROBACTERALES Question 1: Which Enterobacterales Should Be Considered at Moderate to High Risk for Clinically Signific...

Original Investigation  May 31, 2022 Racial and Ethnic Discrepancy in Pulse Oximetry and Delayed Identification of Treatment Eligibility Among Patients With COVID-19 Ashraf Fawzy,  Tianshi David Wu, Kunbo Wang, et al JAMA Intern Med. 2022;182(7):730-738. doi:10.1001/jamainternmed.2022.1906 Key Points Question  Are there systematic racial and ethnic biases in pulse oximetry among patients with COVID-19, and is there an association betwee...

Clinical, Organisational Factors and COVID-19 Mortality Coronavirus disease 2019 (COVID-19) is one of the most significant challenges faced by critical care workers worldwide. During the COVID-19 pandemic, an unprecedented number of patients with COVID-19 associated pneumonia were admitted to the ICU. As a result, most healthcare facilities faced capacity issues and had to designate clinical areas to accommodate these patients and provide them with the necessary cr...

Original Investigation  May 23, 2022 Assessment of Perioperative Outcomes Among Surgeons Who Operated the Night Before Eric C. Sun, Michelle M. Mello, Michelle T. Vaughn, et al JAMA Intern Med. 2022;182(7):720-728. doi:10.1001/jamainternmed.2022.1563 Key Points Question  Is operating overnight associated with worse outcomes for surgical procedures performed by the attending surgeon the subsequent day? Findings  In this cros...