ORIGINAL ARTICLE VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19 Zhujun Cao, Weiyi Gao, Hong Bao, et al N Engl J Med December 28, 2022DOI: 10.1056/NEJMoa2208822 Abstract BACKGROUND Nirmatrelvir–ritonavir has been authorized for emergency use by many countries for the treatment of coronavirus disease 2019 (Covid-19). However, the supply falls short of the global demand, which creates a need for more options. VV116 is an oral antiviral a...

ARTICLES|ONLINE FIRST Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis Alexandre Tran, Shannon M Fernando, Bram Rochwerg, et al. Lancet Respir Med Published:October 10, 2022DOI:https://doi.org/10.1016/S2213-2600(22)00296-X Summary Background Venovenous extracorporeal membrane oxygenation (ECMO) can be considered for patients with COVID-...

Research Christmas 2022: Physical Alcohol related disorders among elite male football players in Sweden: nationwide cohort study Peter Ueda, Björn Pasternak, Henrik Svanström, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-074093 (Published 21 December 2022)Cite this as: BMJ 2022;379:e074093 Abstract Objectives To assess whether male elite football players are at increased risk of alcohol related disorders compared with men from the gen...

Endotypes of Traumatic Brain Injury Traumatic brain injury (TBI) is a heterogeneous disease. It has various injury mechanisms and tissue pathologies. It is a leading cause of mortality and morbidity in young individuals globally. In addition, the incidence of TBI in older patients is an area of concern with an increase in an ageing population that is more likely to be multi-morbid and fall-prone.  Mortality from TBI has decreased over the years. How...

Research Christmas 2022: Don’t Believe the Hype Can artificial intelligence pass the Fellowship of the Royal College of Radiologists examination? Multi-reader diagnostic accuracy study Susan Cheng Shelmerdine, Helena Martin, Kapil Shirodkar, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072826 (Published 21 December 2022)Cite this as: BMJ 2022;379:e072826 Abstract Objective To determine whether an artificial intelligence candidate coul...

Prehospital Lyophilised Plasma Transfusion for Trauma-Induced Coagulopathy Trauma-induced coagulopathy affects approximately 20 to 50% of patients with severe trauma. Its occurrence increases transfusion requirements, multi-visceral failure, and mortality. Blood transfusion is the primary therapy for trauma-induced coagulopathy. However, optimal modalities for plasma transfusion in a prehospital setting remain undefined. Findings from the COMBAT (Control of...

Feature Christmas 2022: The Scientist On the 12th Day of Christmas, a Statistician Sent to Me . . . Richard D Riley, Tim J Cole, Jon Deeks, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072883 (Published 20 December 2022)Cite this as: BMJ 2022;379:e072883 The BMJ’s statistical editors relish a quiet Christmas, so make their wish come true and pay attention to the list of common statistical faux pas presented here by Riley and colleagues ...

Research Christmas 2022: R-E-S-P-E-C-T Direct Uptake of Nutrition and Caffeine Study (DUNCS): biscuit based comparative study Ceri Jones, John Francis BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072839 (Published 19 December 2022)Cite this as: BMJ 2022;379:e072839 Abstract Objectives To identify the time required to achieve optimal palatability of a cup of tea without risk of harm (oral scalding) using the resources available in a standard...

ARTICLES| VOLUME 10, ISSUE 12, P1119-1128, DECEMBER 01, 2022 Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial Holly R Keir, Merete B Long, Hani Abo-Leyah, et al. Lancet Respir Med 2022; 10: 1119-1128 Published:September 05, 2022 DOI: https://doi.org/10.1016/S2213-2600(22)00261-2 Summary Background Neutrophil serine proteases are in...

Venous Thromboembolism in Sepsis Septic patients are often affected by coagulation disorders. Hence, they are at a high risk of thrombotic complications, ranging from widespread microvascular involvement, such as disseminated intravascular coagulation, to venous thromboembolism, arising as deep vein thrombosis or pulmonary embolism. Over the years, knowledge about the interconnected and reciprocal influence of immune and coagulation systems has emerged. This phe...