#EA22: Reducing the Carbon Footprint of Anaesthetics Dr Nicolaas Hendrik Sperna Weiland, anaesthesiologist, Amsterdam University Medical Center, The Netherlands, and founder of the centre's Sustainable Healthcare Team discussed the environmental impact of inhaled anaesthetic agents and the need to massively reduce their use at this year's Euroanaesthesia Congress.  Volatile anaesthetics are potent greenhouse gases with a global warming potential (GWP) from ...

ONLINE FIRST (FREE ACCESS) OPEN ACCESS ~ Original How doctors manage conflicts with families of critically ill patients during conversations about end-of-life decisions in neonatal, pediatric, and adult intensive careSpijkers A.S. et al. Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital c...

Research Letter  July 22, 2022 Association Between Vaccination and Acute Myocardial Infarction and Ischemic Stroke After COVID-19 Infection Young-Eun Kim, Kyungmin Huh, Young-Joon Park, et al JAMA. Published online July 22, 2022. doi:10.1001/jama.2022.12992 Studies have suggested an increased incidence of acute myocardial infarction (AMI) and ischemic stroke after COVID-19 infection related to an increased risk of thrombosis.1,2 Vaccines...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Pain Management Specificities in Critically Ill Patients With Obesity In patients with obesity, standard, non-weight-based dosing, or weight-based dosing using either ideal body weight or adjusted body weight, is appropriate to limit the risk of overdosing. The prevalence of obesity is increasing worldwide (Schetz et al. 2019). This trend is confirmed in the Intensive Care Unit (ICU) where patients wit...

Original Investigation  July 7, 2022 Changes in the Relationship Between Income and Life Expectancy Before and During the COVID-19 Pandemic, California, 2015-2021 Hannes Schwandt, Janet Currie, Till von Wachter, et al JAMA. 2022;328(4):360-366. doi:10.1001/jama.2022.10952 Key Points Question  How did the first 2 years of the COVID-19 pandemic affect life expectancy in California and the relationship between census tract income and life exp...

ORIGINAL ARTICLE Phase 1–2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B Pratima Chowdary, Susan Shapiro, Mike Makris, et al N Engl J Med 2022; 387:237-247DOI: 10.1056/NEJMoa2119913 Abstract BACKGROUND FLT180a (verbrinacogene setparvovec) is a liver-directed adeno-associated virus (AAV) gene therapy that uses a synthetic capsid and a gain-of-function protein to normalize factor IX levels in patients with hemophilia B. METHODS In thi...

ORIGINAL ARTICLE Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 John P. Thornhill, Sapha Barkati, Sharon Walmsley, et al N Engl J Med July 21, 2022DOI: 10.1056/NEJMoa2207323 Abstract BACKGROUND Before April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of infectio...

ORIGINAL ARTICLE BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age Chandra J. Cohen-Stavi, Ori Magen, Noam Barda, et al N Engl J Med 2022; 387:227-236DOI: 10.1056/NEJMoa2205011 Abstract BACKGROUND Limited evidence is available on the real-world effectiveness of the BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) and specifically against infection with the omicron variant among children 5 to 11 years of age. M...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Delirium: How Can We Protect Our Patients? Detection and Treatment Strategies In this article, the authors aim to summarise the current management of delirium, emphasising new publications and possible new studies that will shed light on delirium management strategy. Introduction According to an updated nomenclature of delirium after an interdisciplinary panel of experts from ten medical societies (...

Research Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study Daniel Ayoubkhani, Charlotte Bermingham, Koen B Pouwels, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069676 (Published 18 May 2022)Cite this as: BMJ 2022;377:e069676 Abstract Objective To estimate associations between covid-19 vaccination and long covid symptoms in adults with SARS-CoV-2 infection bef...