Original Investigation  January 3, 2023 Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration: A Randomized Clinical Trial Nicolas Grillot, Gilles Lebuffe, Olivier Huet, et al JAMA. 2023;329(1):28-38. doi:10.1001/jama.2022.23550 Key Points Question  Are rapid-onset opioids noninferior to rapid-onset neuromuscular ...

Editorial  December 16, 2022 Long-term Follow-up After Critical COVID-19: REMAP-CAP Revisited Michael L. Barnett, Paul E. Sax JAMA. Published online December 16, 2022. doi:10.1001/jama.2022.23700 The year 2020 was a grim and uncertain time for any clinician caring for inpatients with COVID-19, especially those with critical illness. In an era of modern medicine in which the range of options for many conditions can seem limitless, this novel v...

Research Letter  November 18, 2022 COVID-19 and Excess All-Cause Mortality in the US and 20 Comparison Countries, June 2021-March 2022 Alyssa Bilinski, Kathryn Thompson, Ezekiel Emanuel JAMA. 2023;329(1):92-94. doi:10.1001/jama.2022.21795 The US experienced high COVID-19 death rates and higher excess all-cause mortality compared with peer countries during 2020.1 However, an important question is how cross-national differences in mortality shifted ...

Editorial  December 27, 2022 The Relationship Between Income and Child Health: New Data for an Old Question Janet Currie, Hannes Schwandt JAMA. 2022;328(24):2402-2403. doi:10.1001/jama.2022.22245 Researchers have been using statistical methods to investigate the link between health and income in both adults and children since individual-level data allowing them to do so first became available.1-3 However, previous investigators were forc...

COMMENT|ONLINE FIRST Nutrition in critical illness—research is worth the EFFORT Emma J Ridley, Lee-anne S Chapple Lancet Published:January 25, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00091-0 Multiple high-quality randomised controlled trials conducted over the past decade in critical care nutrition have shown no difference between interventions and routine care.1, 2, 3, 4 These findings have led to the assumption that nutrition in...

Original Investigation  December 27, 2022 Association of Family Income With Morbidity and Mortality Among US Lower-Income Children and Adolescents Victoria Udalova, Vinayak Bhatia, Maria Polyakova JAMA. 2022;328(24):2422-2430. doi:10.1001/jama.2022.22778 Key Points Question  Among children and adolescents from lower-income families in the US, is family income associated with health? Findings  This cross-sectional stu...

BEST OF JAMA NETWORK Most Viewed Articles 2022 – JAMA Read the most popular JAMA articles in 2022 covering the ongoing COVID-19 pandemic, the latest US Preventive Services Task Force recommendations, management of acute coronary syndromes, and more. COVID-19 False-Positive Results in Rapid Antigen Tests for SARS-CoV-2JAMA Research LetterFebruary 1, 2022 Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to Au...

Medical News & Perspectives  December 27, 2022 JAMA Network Articles of the Year 2022 Melissa Suran JAMA. 2022;328(24):2381-2385. doi:10.1001/jama.2022.17761 For our sixth annual Articles of the Year roundup, we considered all Original Investigations, Special Communications, and Brief Reports published across the JAMA Network from October 1, 2021, through September 30, 2022, and ranked them based on online views. Editors from each journal...

Continuous Cuff Pressure Control in Preventing Ventilator-Associated Pneumonia Patients in the ICU often require invasive mechanical ventilation support. This requires tracheal intubation, where an endotracheal cuff wrapped around the tip of the tube seals the extraluminal airway for positive pressure ventilation. Inappropriate cuff pressure control can contribute to ventilator-associated complications. Studies report that approximately 10–20% of long-term (≥ 48 hr...

EDITORIAL Extracorporeal CPR in Out-of-Hospital Cardiac Arrest — Still on Life Support? John F. Keaney, Jr., Thomas Münzel N Engl J Med 2023; 388:370-371DOI: 10.1056/NEJMe2214116 Despite many advances in the treatment of heart disease over the past four decades, up to one third of all patients with acute manifestations of heart disease do not reach the hospital after cardiac arrest. Only 8 to 10% of patients with out-of-hospital cardiac arrest survive; the eve...