Editorial  December 16, 2022 Long-term Follow-up After Critical COVID-19: REMAP-CAP Revisited Michael L. Barnett, Paul E. Sax JAMA. Published online December 16, 2022. doi:10.1001/jama.2022.23700 The year 2020 was a grim and uncertain time for any clinician caring for inpatients with COVID-19, especially those with critical illness. In an era of modern medicine in which the range of options for many conditions can seem limitless, this novel v...

Research Letter  Climate Change and Health December 20, 2022 Association Between the 2021 Heat Wave in Portland, Oregon, and Seattle, Washington, and Emergency Department Visits Amruta Nori-Sarma, Chad Milando, Kate R. Weinberger, et al JAMA. 2022;328(23):2360-2362. doi:10.1001/jama.2022.20665 Heat waves are becoming more frequent and severe, with pronounced effects on human health.1 In late June 2021, temperatures in the US Pacific N...

ICU Professionals’ Knowledge of End-of-Life Decision-Making Law There are laws regulating healthcare practice at the end of life. Most healthcare professionals rely on their clinical knowledge to inform treatment decisions during this time. However, the extent to which the law informants their decision-making at the end of life remains uncertain.  In this study, the researchers describe what healthcare professionals in the ICU and emergency departments know...

JAMA Insights  Genomics and Precision Health December 16, 2022 RNA Sequencing as a Diagnostic Tool Shamika Ketkar, Lindsay C. Burrage, Brendan Lee JAMA. Published online December 16, 2022. doi:10.1001/jama.2022.22843 RNA sequencing (RNA-seq) is a new tool in the genetic diagnostic laboratory made possible by the advent of low-cost, high-throughput, next-generation sequencing technology. Historically, RNA studies were limited to g...

Original Investigation  Caring for the Critically Ill Patient December 16, 2022 Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial Writing Committee for the REMAP-CAP Investigators JAMA. Published online December 16, 2022. doi:10.1001/jama.2022.23257 Key Points Question  What is the effect of treatment for critically ill patients with COVID-19 on longer-term mortali...

Research Rivaroxaban treatment for six weeks versus three months in patients with symptomatic isolated distal deep vein thrombosis: randomised controlled trial Walter Ageno, Lorenza Bertù, Eugenio Bucherini, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072623 (Published 23 November 2022)Cite this as: BMJ 2022;379:e072623 Abstract Objective To compare two different treatment durations of rivaroxaban in patients with symptomatic isolated di...

CRT Kinetics After Fluid Infusion Peripheral tissue hypoperfusion is a strong predictor of poor outcomes in patients suffering from severe conditions, such as sepsis, cardiac arrest or cardiogenic shock. The evaluation of peripheral tissue perfusion is very important in identifying shock patients. This can be done at the bedside with either semi-quantitative tools such as the mottling score, or quantitative tools, such as skin temperature and the capillary refill t...

Research Global burden of type 2 diabetes in adolescents and young adults, 1990-2019: systematic analysis of the Global Burden of Disease Study 2019 Jinchi Xie, Maoqing Wang, Zhiping Long, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072385 (Published 07 December 2022)Cite this as: BMJ 2022;379:e072385 Abstract Objective To estimate the global burden of type 2 diabetes in adolescents and young adults (aged 15-39 years) from 1990 to 2019. ...

Editorials Awake prone positioning and covid-19 Amol A Verma, Fahad Razak, Laveena Munshi, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj.o2888 (Published 07 December 2022)Cite this as: BMJ 2022;379:o2888 Safely reduces intubation for patients with hypoxaemia In a linked paper, Weatherald and colleagues (doi:10.1136/bmj-2022-071966) offer the most up-to-date evidence synthesis evaluating the use of awake prone positioning in adults with covid-19 ...

Research Efficacy of awake prone positioning in patients with covid-19 related hypoxemic respiratory failure: systematic review and meta-analysis of randomized trials Jason Weatherald, Ken Kuljit S Parhar, Zainab Al Duhailib, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071966 (Published 07 December 2022)Cite this as: BMJ 2022;379:e071966 Abstract Objective To determine the efficacy and safety of awake prone positioning versus usual care i...