Editorial  Can Transesophageal Echocardiography–Guided CPR Improve Out-of-Hospital Cardiac Arrest Outcomes? Teva D. Brender, Tracy Y. Wang, Sharon K. Inouye, et al JAMA Intern Med Published Online: March 23, 2026 doi: 10.1001/jamainternmed.2026.0115 Worldwide, an estimated 3.8 million persons experience an out-of-hospital cardiac arrest (OHCA) annually.1 In the United States, only 8.2% of individuals with an OHCA survive with a favorable neurological o...

ORIGINAL ARTICLE Conservative Oxygen for Unresponsive Patients after Cardiac Arrest The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMoa2513814 Abstract BACKGROUND In patients who are unresponsive after resuscitation from cardiac arrest, limiting oxygen exposure to that necessary to achieve acceptable oxygenation may increase the likelihood of...

Research Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study Katie Scandrett, Alice J Sitch, Jonathan Barratt, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-085005 (Published 19 March 2026)Cite this as: BMJ 2026;392:e085005 Abstract Objectives To provide evidence on the longitudinal accuracy of glomerular filtrat...

Acute Respiratory Distress Syndrome Molecular Phenotypes In ICU Wed, 21 Jan 2026 A new study investigated whether the two well-established molecular phenotypes of acute respiratory distress syndrome (ARDS)—hyperinflammatory and hypoinflammatory—are associated with distinct biological processes in the lung. Although these phenotypes were originally defined using plasma biomarkers and clinical variables and are known to differ in prognosis and treatment ...

Original Investigation  Transesophageal Echocardiography During CPR in Patients With Out-of-Hospital Cardiac Arrest: The EXECT-CPR Randomized Clinical Trial Sheng-En Chu, Chiao-Yin Cheng, Chih-Jung Chang, et al JAMA Intern Med Published Online: March 23, 2026 doi: 10.1001/jamainternmed.2026.0102 Key Points Question  Does transesophageal echocardiography (TEE)–guided cardiopulmonary resuscitation...

SPECIAL ARTICLE Society of Critical Care Medicine Guidelines on Caring for Older Adults in the ICU Ferrante, Lauren E.; Chaudhuri, Dipayan; Laiya Carayannopoulos, Kallirroi; et al Critical Care Medicine March 20, 2026 DOI: 10.1097/CCM.0000000000007085 Rationale:  Older adults (those 65 years old or greater) compose a substantial proportion of the ICU population. As older adults with critical illness possess unique factors and considerations relevant...

SPECIAL ARTICLE Society of Critical Care Medicine Guidelines for the Administration of Neuromuscular Blockade in Adults With Acute Respiratory Distress Syndrome Erstad, Brian L; Cobas, Miguel A; Qadir, Nida; et al Critical Care Medicine 54(3):p 634-643, March 2026. DOI: 10.1097/CCM.0000000000007002 Rationale:  Neuromuscular blocking agents (NMBAs) show potential benefits on mortality and other complications of acute respiratory distress syndrome (AR...

How Different Oximeters Affect Clinical Decision-Making In ICU Wed, 28 Jan 2026 An observational method comparison study examined whether different pulse oximetry devices provide consistent nocturnal oxygen saturation measurements in stable adults treated with continuous positive airway pressure (CPAP) or long-term noninvasive ventilation (NIV). Although overnight pulse oximetry is widely recommended to detect residual sleep-disordered breathing (SDB),...

Editorial  Surveillance of Sepsis in Children—Making Every Case Count Luregn J. Schlapbach, Shu-Ling Chong, Nora Luethi JAMA Published Online: March 22, 2026 doi: 10.1001/jama.2026.2814 Sepsis is a leading cause of hospital admissions, mortality, and health care expenditure worldwide. It disproportionally affects very young and very old individuals. Sepsis in young individuals carries a magnified societal impact through potential years of life lost and...

ARTICLE March 22, 2026 Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial Stacy Todd, Joanne Euden, Jennifer Condie, et al Lancet Respir Med Published March 22, 2026 DOI: 10.1016/S2213-2600(25)00433-3 Summary Background Sepsis is a co...