Postextubation Noninvasive Respiratory Support in Patients with Acute Brain Injury: Not a Panacea, but Don’t Throw the Baby Out with the Bathwater! Romain Pirracchio and  Alejandro A. Rabinstein Am J Respir Crit Care Med 2023; 208: 225-226 Extubation failure is a common problem in patients with acute brain injury, with rates ranging from 15% to 25% across studies (1–3). Older age, longer duration of mechanical ventilation, and impaired airway protective reflexes ...

ICU Management & Practice, Volume 23 - Issue 1, 2023 Utility of Biomarkers in Obstetric Patients With Preeclampsia Preeclampsia is a complex syndrome whose complications bear an impact on perinatal morbidity and mortality. Angiogenic biomarkers may significantly impact both the decision to admit patients and risk stratification and may also help guide patient management and level of care. Preeclampsia is one of the main causes of maternal and foetal morb...

ARTICLES|ONLINE FIRST Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study Xianming Zhu, Kelly A Gebo, Alison G Abraham, et al Lancet Microbe Published:August 07, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00171-4 Summary Background Cytokines and chemokines play a critical role in the response to infection and vaccination. We aimed to assess the longitudinal association of COVID...

Enhancing the Efficacy of Mesenchymal Stromal Cells in COVID-19–related Acute Respiratory Distress Syndrome Haibo Zhang and  Arthur S. Slutsky Am J Respir Crit Care Med 2023; 208: 222-224 Mesenchymal stromal cells (MSCs) have garnered considerable attention as a potential therapeutic option for patients with acute respiratory distress syndrome (ARDS) because of their capacity to modulate inflammation and promote tissue repair (1, 2). In this editorial, we su...

Research Association between antenatal corticosteroids and risk of serious infection in children Tsung-Chieh Yao, Sheng-Mao Chang, Chi-Shin Wu, et al BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2023-075835 (Published 02 August 2023)Cite this as: BMJ 2023;382:e075835 Abstract Objective To investigate the associations between exposure to antenatal corticosteroids and serious infection in children during the first three, six, and 12 months of life. ...

Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicenter, Randomized, Controlled Clinical Trial Ellen A. Gorman,  Jennifer Rynne,  Hannah J. Gardiner, et al Am J Respir Crit Care Med 2023; 208: 256-269 Abstract Rationale: Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair in coronavirus disease (COVID-19)–related acute respiratory distress syndrome (ARDS). Objectives: ...

ICU Management & Practice, Volume 22 - Issue 5, 2022 Bedside Point-of-Care Ultrasound Use in the Critically Ill Historical Perspectives and a Path Forward Critical Care Ultrasound is a rapidly evolving field with an ever-expanding footprint in ICUs. While much progress has been made, ongoing efforts need to continue towards demonstrating impact on patient-oriented outcome measures and on defining educational curricula and competency requirements. Poin...

Viral-associated Pulmonary Aspergillosis: Have We Finally Overcome the Debate of Colonization versus Infection? Werner C. Albrich and  Frédéric Lamoth Am J Respir Crit Care Med 2023; 208: 230-231 Invasive pulmonary aspergillosis (IPA) has emerged in the ICU setting following the recent influenza H1N1 and coronavirus disease (COVID-19) pandemics. Viral-associated IPA (VAPA) is quite different than classical IPA in terms of pathogenicity and clinical presentation i...

A Pathology-based Case Series of Influenza- and COVID-19–associated Pulmonary Aspergillosis: The Proof Is in the Tissue Lore Vanderbeke,  Cato Jacobs,  Simon Feys, et al Am J Respir Crit Care Med 2023; 208: 301-311 Abstract Rationale: Invasive pulmonary aspergillosis has emerged as a frequent coinfection in severe coronavirus disease (COVID-19), similarly to influenza, yet the clinical invasiveness is more debated. Objectives: We investigated the ...

ICU Management & Practice, Volume 23 - Issue 2, 2023 Early Mobilisation in Patients Undergoing Extracorporeal Membrane Oxygenation Extracorporeal membrane oxygenation is a resource that is accessible in hospitals and intensive care units all over the world. In serious situations, ECMO therapy is intended to provide haemodynamic and/or ventilatory support. Because of this, many people refer to the ECMO patient as "the most critical patient." As a result, the...