ORIGINAL ARTICLE Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia Stephan Ehrmann, François Barbier, Julien Demiselle, et al N Engl J Med October 25, 2023DOI: 10.1056/NEJMoa2310307 Abstract BACKGROUND Whether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear. METHODS In this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critica...

ORIGINAL ARTICLE Simvastatin in Critically Ill Patients with Covid-19 The REMAP-CAP Investigators N Engl J Med October 25, 2023DOI: 10.1056/NEJMoa2309995 Abstract BACKGROUND The efficacy of simvastatin in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS In an ongoing international, multifactorial, adaptive platform, randomized, controlled trial, we evaluated simvastatin (80 mg daily) as compared with no statin (c...

Invited Commentary  September 20, 2023 New Technology and Bile Duct Injuries Liane S. Feldman, L. Michael Brunt JAMA Surg. Published online September 20, 2023. doi:10.1001/jamasurg.2023.4404 Thirty-five years ago, the rapid adoption of laparoscopic cholecystectomy ushered in the minimally invasive surgical revolution. Combining 2 preexisting and safe operations, this transformative innovation nonetheless resulted in unexpected patient harms: ...

ORIGINAL ARTICLE Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients Benoît Misset,  Michael Piagnerelli, Eric Hoste, et al N Engl J Med 2023; 389:1590-1600DOI: 10.1056/NEJMoa2209502 Abstract BACKGROUND Passive immunization with plasma collected from convalescent patients has been regularly used to treat coronavirus disease 2019 (Covid-19). Minimal data are available regarding the use of convalescent plasma in patients with ...

Special Communication  October 12, 2023 Red Blood Cell Transfusion: 2023 AABB International Guidelines Jeffrey L. Carson, Simon J. Stanworth, Gordon Guyatt, et al JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.12914 Abstract Importance  Red blood cell transfusion is a common medical intervention with benefits and harms. Objective  To provide recommendations for use of red blood cell transfusion in adu...

Original Investigation  Caring for the Critically Ill Patient October 25, 2023 Intravenous Vitamin C for Patients Hospitalized With COVID-19Two Harmonized Randomized Clinical Trials The LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators JAMA. Published online October 25, 2023. doi:10.1001/jama.2023.21407 Key Points Question  Does vitamin C administered intravenously...

October 25, 2023 Landiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial Tony Whitehouse, Anower Hossain, Gavin D. Perkins, et al JAMA. Published online October 25, 2023. doi:10.1001/jama.2023.20134 Key Points Question  Does β-blockade for up to 14 days with landiolol reduce organ failure as measured by the Sequential Organ Failure Assessment (SOFA) score for critically ill patients with tachycar...

Editorial  October 14, 2023 Acute Kidney Injury With Empirical Antibiotics for Sepsis Steven Y. C. Tong, Balasubramanian Venkatesh, Erin K. McCreary JAMA. Published online October 14, 2023. doi:10.1001/jama.2023.18591 Sepsis describes life-threatening organ dysfunction due to a dysregulated host response to infection. It is a global health priority affecting 55 million people worldwide causing 11 million deaths annually.1 Failure to init...

ORIGINAL RESEARCH|ARTICLES IN PRESS Artificial Intelligence improves novices’ bronchoscopy performance – a randomized controlled trial in a simulated setting Kristoffer Mazanti Cold, Sujun Xie, Anne Orholm Nielsen, et al Chest Open Access Published:August 22, 2023 DOI:https://doi.org/10.1016/j.chest.2023.08.015 Abstract Background Navigating through the bronchial tree and visualizing all bronchial segments is the initial step toward learning flexible ...

Original Investigation  Caring for the Critically Ill Patient October 14, 2023 Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial Edward T. Qian, Jonathan D. Casey, Adam Wright, et al JAMA. 2023;330(16):1557-1567. doi:10.1001/jama.2023.20583 Key Points Question  Does the choice between cefepime and piperacillin-tazobactam affect ...