Original Investigation  May 25, 2023 Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, et al JAMA. 2023;329(22):1934-1946. doi:10.1001/jama.2023.8823 Key Points Question  What symptoms are differentially present in SARS-CoV-2–infected individuals 6 months or more after infection compared with uninfected individuals, and what symptom-based criteria can be us...

Tight Blood-Glucose Control Without Early Parenteral Nutrition Randomised, controlled trials conducted in ICUs show mixed results regarding the benefits and risks of tight blood glucose control. This inconsistency in findings may be attributed to differences in the administration of early parenteral nutrition and the occurrence of insulin-induced severe hypoglycaemia. In this study, patients admitted to the ICU were randomly assigned to two groups: one receiving...

Original Investigation  November 6, 2023 Overnight Stay in the Emergency Department and Mortality in Older Patients Melanie Roussel, Dorian Teissandier, Youri Yordanov, et al JAMA Intern Med. Published online November 6, 2023. doi:10.1001/jamainternmed.2023.5961 Key Points Question  Is spending a night in the emergency department (ED) associated with increased in-hospital mortality and morbidity...

Magnesium sulphate in patients with thrombotic thrombocytopenic purpura (MAGMAT): a randomised, double-blind, superiority trial Lara Zafrani, Emmanuel Canet, Anouk Walter-Petrich, et al Intensive Care Med 2023; 49: 1293-1304 Published: 23 October 2023 Abstract Purpose Studies have suggested benefits from magnesium sulphate in thrombotic thrombocytopenic purpura (TTP). We aimed to measure the effects of magnesium sulphate supplementation on TTP recovery. ...

ARTICLES| VOLUME 4, ISSUE 11, E883-E892, NOVEMBER 2023 Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis Eva Stadler, Khai Li Chai, Timothy E Schlub, et al Lancet Microbe 2023; 4: E883-E892 Published:November, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00194-5 Summary Background Randomised controlled trials of passive antibodies as treatment and prophylaxis for COVID-19 have reported variable eff...

Virtual and Augmented Reality in the ICU Virtual reality (VR) and augmented reality (AR) are emerging technologies with diverse applications, from entertainment and education to medical care. VR immerses users in a virtual three-dimensional environment, while AR retains connection to the real world while increasing information through the use of virtual elements. Both require specialised VR/AR glasses. These technologies have already found extensive use in healt...

ARTICLES| VOLUME 4, ISSUE 11, E893-E902, NOVEMBER 2023Download Full Issue Transplacental transfer efficiency of maternal antibodies against influenza A(H1N1)pdm09 virus and dynamics of naturally acquired antibodies in Chinese children: a longitudinal, paired mother–neonate cohort study Mei Li, Wei Wang, Junbo Chen, et al Lancet Microbe 2023; 4: E893-E902 Published:October 09, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00181-7 Summary Back...

ARTICLES| VOLUME 4, ISSUE 11, E903-E912, NOVEMBER 2023 Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010–19: a repeated cross-sectional study Kelsey M Sumner, Svetlana Masalovich, Alissa O'Halloran, et al Lancet Microbe 2023; 4: E903-E912 Published: September 25, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00187-8 Summary Background Influenza burden varies across seasons, partly due to differences i...

Vasopressin Loading for Refractory Septic Shock Vasopressin is a potent vasopressor used to treat septic shock, acting via a different receptor than catecholamines. Previous randomised control trials have demonstrated its efficacy. However, its use can also lead to adverse effects such as ischaemia events. Therefore, it is recommended as a second-line agent after noradrenaline. Typically, vasopressin is given as a continuous infusion up to 0.03 U/min (1.8 U/h). ...

ARTICLES| VOLUME 4, ISSUE 11, E931-E942, NOVEMBER 2023 Effect of amoxicillin on the gut microbiome of children with severe acute malnutrition in Madarounfa, Niger: a retrospective metagenomic analysis of a placebo-controlled trial Drew J Schwartz, Amy Langdon, Xiaoqing Sun, et al Lancet Microbe 2023; 4: E931-E942 Published:October 19, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00213-6 Summary Background Children with severe acute malnu...