Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial Obling, L.E.R., Beske, R.P., Meyer, M.A.S. et al. Intensive Care Med 2023; 49: 1467–1478 Abstract Purpose Patients who are successfully resuscitated following out-of-hospital cardiac arrest (OHCA) are still at a high risk of neurological damage and death. Inflammation and brain injury are components of the post-cardiac arr...

High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial Raffaele Di Fenza,  Naman S. Shetty,  Stefano Gianni, et al Am J Respir Crit Care Med 2023; 208: 1293-1304 Abstract Rationale: The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown. Objectives: The primary outcome was the change in arterial oxygenation (PaO2...

The Minnesota Medical Operations Coordination Center: A COVID-19 Statewide Response to Ensure Access to Critical Care and Medical-Surgical Beds Karyn D. Baum, Lauren Vlaanderen, Walter James, et al Chest 2024; 165: 95-109 Background COVID-19 led to unprecedented inpatient capacity challenges, particularly in ICUs, which spurred development of statewide or regional placement centers for coordinating transfer (load-balancing) of adult patients needing intensive ...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Neonatal Extracorporeal Membrane Oxygenation Xenios sponsored a lunch symposium at the 16th European Conference on Paediatric and Neonatal Ventilation (EPNV) in Montreux (CH) in May 2023. Matteo Di Nardo (Italy) introduced the audience to extracorporeal membrane oxygenation (ECMO) in neonates. Florian Kipfmüller (Germany) presented current knowledge and his experience with ECMO in neonates with congenital...

ONLINE FIRST (FREE ACCESS) TOP 6 MOST CITED ARTICLES IN 2023 OriginalEchocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID studyHuang S. et al. Direct assessment of microcirculation in shock: a randomized-controlled multicenter studyRomano Bruno R. et al. Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care...

ORIGINAL ARTICLE Skin Antisepsis before Surgical Fixation of Extremity Fractures The PREP-IT Investigators N Engl J Med 2024; 390:409-420DOI: 10.1056/NEJMoa2307679 BACKGROUND Studies evaluating surgical-site infection have had conflicting results with respect to the use of alcohol solutions containing iodine povacrylex or chlorhexidine gluconate as skin antisepsis before surgery to repair a fractured limb (i.e., an extremity fracture). METHODS In a cl...

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 165, ISSUE 1, P68-78, JANUARY 2024 Comparative Effectiveness of First-Line and Alternative Antibiotic Regimens in Hospitalized Patients With Nonsevere Community-Acquired Pneumonia: A Multicenter Retrospective Cohort Study Anthony D. Bai, Siddhartha Srivastava, Benjamin K.C. Wong, et al Chest 2024; 165: 68-78 Published: August 10, 2023 DOI: https://doi.org/10.1016/j.chest.2023.08.008 Background There are several...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Transforming a PICU in the Digital Age Digitalisation is ultimately the driving force behind digital transformation. It will take us from a reactive healthcare system to a proactive one that focuses on prediction and prevention. Introduction The digital transformation has left a few things untouched in recent years, radically changing healthcare management for citizens, professionals, and public hea...

Research Letter  Health Care Policy and Law January 2, 2024 Automated External Defibrillator Use After Out-of-Hospital Cardiac Arrest at Recreational Facilities Ahmed A. Kolkailah, Paul S. Chan, Qiang Li, et al JAMA Intern Med. Published online January 2, 2024. doi:10.1001/jamainternmed.2023.7248 Out-of-hospital cardiac arrest (OHCA) during exercise is often due to a ventricular arrhythmia for which prompt defibrillation from an automated ...

CHEST COMMENTARY| VOLUME 165, ISSUE 1, P16-18, JANUARY 2024Download Full Issue Upcoming Clinical Trials in Critical Care, Diffuse Lung Disease, Pulmonary Vascular Disease, and Thoracic Oncology in 2024 Adam Edward Lang, Michael N. Kammer, Aravind Menon, et al Chest 2024; 165: 16-18 DOI:https://doi.org/10.1016/j.chest.2023.07.029 Abbreviations:  CTEPH (chronic thromboembolic pulmonary hypertension), IPF(idiopathic pulmonary f...