ICU Management & Practice, Volume 24 - Issue 1, 2024 Defining Medicines Optimisation in the Intensive Care Unit Complex polypharmacy and pathophysiology are common in the intensive care unit (ICU). Medicines optimisation is essential to deliver safe, effective, and individualised pharmacotherapy. This is ideally performed by a specialised ICU pharmacist. Introduction Medicines are the most common intervention in healthcare and are a central compo...

Research 25 year trends in cancer incidence and mortality among adults aged 35-69 years in the UK, 1993-2018: retrospective secondary analysis Jon Shelton, Ewa Zotow, Lesley Smith, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-076962 (Published 13 March 2024)Cite this as: BMJ 2024;384:e076962 Abstract Objective To examine and interpret trends in UK cancer incidence and mortality for all cancers combined and for the most common cancer sites ...

ICU Management & Practice, Volume 24 - Issue 1, 2024 Haemoadsorption in Critically Ill Patients: The New Frontier Haemoadsorption may represent the new frontier in extracorporeal blood purification. Haemoadsorption has demonstrated effective extraction of a variety of toxins and drugs during episodes of sepsis, acute kidney injury or intoxication. Selective haemoadsorption can be performed by endotoxin-binding polymyxin B functionalised polystyrene fibres. The c...

Original Investigation  Cardiology February 1, 2024 Differential Associations of Alcohol Use With Ischemic Heart Disease Mortality by Socioeconomic Status in the US, 1997-2018 Yachen Zhu, Laura Llamosas-Falcón, William Kerr, et al JAMA Netw Open. 2024;7(2):e2354270. doi:10.1001/jamanetworkopen.2023.54270 Key Points Question  Does socioeconomic status (SES) modify the association of alcohol use with ischemic heart disease (IHD)...

Original Investigation  March 13, 2024 Accreditation Council for Graduate Medical Education Milestone Training Ratings and Surgeons’ Early Outcomes Brigitte K. Smith, Kenji Yamazaki, Ara Tekian, et al JAMA Surg. Published online March 13, 2024. doi:10.1001/jamasurg.2024.0040 Key Points Question  Does assessment of surgical competence using Accreditation Council for Graduate Medical Education Milestones during training predict fut...

ICU Management & Practice, Volume 24 - Issue 1, 2024 Corticosteroids in the Intensive Care Unit: Evidence-Based Recommendations Corticosteroids are commonly used drugs in multiple diseases and conditions of critically ill patients. In this article, we review the pharmacology of corticosteroids and provide recommendations for their use in the ICU based on the best available evidence. Corticosteroids: Pharmacology and General Aspects Corticosteroids are...

Original Investigation  Infectious Diseases March 13, 2024 Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria Sonali D. Advani, David Ratz, Jennifer K. Horowitz, et al JAMA Netw Open. 2024;7(3):e242283. doi:10.1001/jamanetworkopen.2024.2283 Key Points Question  What is the prevalence of bacteremia from a presumed urinary source in hospitalized patients with asymptomatic bacteriuria (...

Original Investigation  Surgery February 2, 2024 Risk of Venous Thromboembolic Events After Surgery for Cancer Johan Björklund, Juhana Rautiola, Renata Zelic, et al JAMA Netw Open. 2024;7(2):e2354352. doi:10.1001/jamanetworkopen.2023.54352 Key Points Question  Is major cancer surgery associated with an increased risk of venous thromboembolism after surgery? Findings  This population-based nationwide cohort study c...

Editorial Venous Doppler for Echocardiographic Right Atrial Pressure Estimation: Ready for Primetime? Jean Deschamps, William Beaubien-Souligny Chest 2024; 165: 478-481 https://doi.org/10.1016/j.chest.2023.11.007 For the last decade, inferior vena cava (IVC) measurements and variability have been the de facto noninvasive echocardiographic measurement to infer right-sided filling pressures and remain at the forefront of current echocardiography guidelines.1D...

ORIGINAL ARTICLE Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria Régis Peffault de Latour, Alexander Röth, Austin G. Kulasekararaj, et al N Engl J Med 2024; 390:994-1008DOI: 10.1056/NEJMoa2308695 Abstract BACKGROUND Persistent hemolytic anemia and a lack of oral treatments are challenges for patients with paroxysmal nocturnal hemoglobinuria who have received anti-C5 therapy or have not received complement inhibitors. Iptacopan, a first-...