Pulmonary Haemodynamic Trajectories in ECMO-Supported ARDS In ICU Wed, 4 Mar 2026 A recent study investigated the prevalence, determinants, and prognostic implications of pulmonary hypertension (PH) in patients with acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (V-V ECMO). PH, defined as a mean pulmonary artery pressure (mPAP) greater than 20 mmHg, is a recognised complication of ARDS and cont...

Research Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis Chanyan Huang, Xu Zhao, Siyu Geng, et al BMJ 2026; 393 doi: https://doi.org/10.1136/bmj-2025-089001 (Published 09 April 2026)Cite this as: BMJ 2026;393:e089001 Abstract Objective To evaluate the effectiveness of perioperative non-drug interventions in reducing postoperative pulmonary complications (P...

WHO guidelines for the clinical management of filovirus disease: Executive summary Key recommendations Systematic patient monitoring should be established for patients with suspected or confirmed filovirus disease, using structured and documented clinical assessment at regular intervals, with frequency adapted to patient condition (Good practice statement). WHO recommends that for patients with suspected or confirmed filovirus disease, systematic laboratory moni...

Invited Commentary  The Mechanics of Improving Compliance Meghan C. O’Leary, Jessica R. Schumacher, Gita N. Mody JAMA Surg Published Online: April 15, 2026 doi: 10.1001/jamasurg.2026.0897 We were pleased to read the report by Chan et al1 about an American College of Surgeons national quality improvement (QI) collaborative. The Lung Nodal, Operative, Dissection, Evaluation, and Staging (NODES) initiative involved a collection of multilevel interventions...

Albumin Replacement Therapy in Septic Shock In Sepsis Wed, 4 Mar 2026 The Albumin Replacement Therapy in Septic Shock (ARISS) trial, published in JAMA Network Open was designed to determine whether albumin replacement improves survival in patients with septic shock. The study was conducted on behalf of the SepNet Critical Care Trials Group and ARISS investigators. Albumin is a natural colloid with physiological roles extending beyond maintenance of ...

Original Investigation  Fecal Microbiota Transplant and Multidrug-Resistant Organism Decolonization in Gastrointestinal Disease: A Randomized Clinical Trial Himanshu Narang, Daizee Talukdar, Bipul Kumar, et al JAMA Intern Med Published Online: April 20, 2026 doi: 10.1001/jamainternmed.2026.0655 Key Points Question  Is fecal microbiota transplant (FMT) effective in achieving gut decolonization of...

Original Investigation  Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia: The FAST Randomized Clinical Trial Ritu Banerjee, Lauren Komarow, Yixuan Li, et al JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2026.5487 Key Points Question  Does use of rapid antimicrobial susceptibility testing directly from blood culture bottles positive for gram-negative bacteria impro...

Integrating Circadian Medicine in Critical Care A structured roadmap for integrating circadian medicine into critical care was developed during a five-day international workshop held at the Lorentz Center in Leiden, The Netherlands. Circadian rhythms, self-sustained approximately 24-hour physiological cycles regulated by a central clock in the suprachiasmatic nucleus and peripheral clocks throughout the body, are fundamental to human health. In the ICU, however, th...

Original Investigation  Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults Timothy J. Savage, Anne M. Butler, Matthew P. Kronman, et al JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2025.26902 Key Points Question  For acute sinusitis in adults younger than 65 years, is standard-dose amoxicillin-clavulanate associated with different risks of treatment failure and adver...

Original Investigation  Gastroenterology and Hepatology Computer-Assisted Colonoscopy in High–Adenoma Detection Rate Settings in a High-Risk Population: A Randomized Clinical Trial Wen-Feng Hsu, Chen-Ya Kuo, Hsu-Heng Yen, et al JAMA Netw Open 2026;9;(4):e264881. doi:10.1001/jamanetworkopen.2026.4881 Key Points Question  Does the use of computer-aided detection (CAD) during colonoscopy improve adenoma dete...