ARTICLES|ONLINE FIRST National, regional, and global estimates of low birthweight in 2020, with trends from 2000: a systematic analysis Yemisrach B Okwaraji, Julia Krasevec, Ellen Bradley, et al Lancet Published: February 28, 2024 DOI: https://doi.org/10.1016/S0140-6736(23)01198-4 Summary Background Low birthweight (LBW; <2500 g) is an important predictor of health outcomes throughout the life course. We aimed to update country, regional, and globa...

ICU Management & Practice, Volume 23 - Issue 5, 2023 Long-Term Home Ventilation in Children: Facing the Challenge Discharging ventilated children home is a difficult challenge in which the training of families is essential. We present our hospital's transition programme for ventilated children going home, which is based on a family-centred model. Introduction  The progressive improvement of neonatal intensive care (NICU) and paediatric intensive ...

Original Investigation  February 26, 2024 Racial Differences in Shared Decision-Making About Critical Illness Deepshikha C. Ashana, Whitney Welsh, Doreet Preiss, et al JAMA Intern Med. Published online February 26, 2024. doi:10.1001/jamainternmed.2023.8433 Key Points Question  How do critical care clinicians approach shared decision-making with Black compared with White caregivers of critically ill patients? Findings &nbs...

Original Investigation  February 26, 2024 COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes Abinet M. Aklilu, Sanchit Kumar, James Nugent, et al JAMA Intern Med. Published online February 26, 2024. doi:10.1001/jamainternmed.2023.8225 Key Points Question  Are hospitalized patients who develop acute kidney injury (AKI) associated with COVID-19 at risk of worse kidney function trajectory and higher mortality t...

ICU Management & Practice, Volume 23 - Issue 5, 2023 Administering Care to Critically Ill Patients with FAST HUGS IN BED PLEASE - Revisited Mnemonic In the ICU, providing better care with less is the holy grail. This mnemonic tries to resume a list of the key interventions for human, evidence-based and patient-centred care. Background In 2005, Prof Jean-Louis Vincent introduced the mnemonic "FAST HUG," advocating for a comprehensive approach to patien...

Original Investigation  June 6, 2023 Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial Ajit P. Limaye, Klemens Budde, Atul Humar, et al JAMA. 2023;330(1):33-42. doi:10.1001/jama.2023.9106 Key Points Question  Is prophylaxis with letermovir noninferior to valganiclovir for cytomegalovirus (CMV) disease prevention in high-risk CMV-seronegative kidney transpl...

ORIGINAL ARTICLE Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection Gregory W. Albers, Mouhammad Jumaa, Barbara Purdon, et al N Engl J Med 2024; 390:701-711DOI: 10.1056/NEJMoa2310392 Abstract BACKGROUND Thrombolytic agents, including tenecteplase, are generally used within 4.5 hours after the onset of stroke symptoms. Information on whether tenecteplase confers benefit beyond 4.5 hours is limited. METHODS We conducted a mul...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 165, ISSUE 2, P348-355, FEBRUARY 2024 Peripheral Administration of Norepinephrine: A Prospective Observational Study Jason R. Yerke, Eduardo Mireles-Cabodevila, Alyssa Y. Chen, et al Chest 2024; 165: 348-355 Published:August 20, 2023 DOI:https://doi.org/10.1016/j.chest.2023.08.019 Background Historically, norepinephrine has been administered through a central venous catheter (CVC) because of concerns about the risk o...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 165, ISSUE 2, P333-347, FEBRUARY 2024 Low Tidal Volume Ventilation Is Poorly Implemented for Patients in North American and United Kingdom ICUs Using Electronic Health Records Romit J. Samanta, Ari Ercole, Steven Harris, et al Chest 2024; 165: 333-347 Published:September 27, 2023 DOI:https://doi.org/10.1016/j.chest.2023.09.021 Background Low tidal volume ventilation (LTVV; < 8 mL/kg predicted body weight...

Cardiovascular Management in Septic Shock: Optimising Vascular and Cardiac Function An overview of vasopressor management, current evidence on its use, when to initiate vasopressor therapy for best possible patient outcome and a discussion regarding the use of landiolol in septic patients with persistent tachycardia.   Optimising Vasopressin Initiation in Septic Shock Patients with septic shock, and especially those with high vasopressor needs, are at r...