ARTICLES|ONLINE FIRST Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 GBD 2021 Causes of Death Collaborators Lancet Open Access Published: April 03, 2024 DOI: https://doi.org/10.1016/S0140-6736(24)00367-2 Summary Background Regular, detailed reporting on population health by underlying caus...

Past, Present, and Future of Sustainable Intensive Care In ICU Tue, 14 May 2024 Climate change is a critical challenge of the 21st century, with fossil fuel combustion being the largest contributor, responsible for over 75% of greenhouse gas (GHG) emissions. The global healthcare industry significantly impacts the environment, accounting for up to 5% of global carbon emissions, with the U.S. contributing the largest share. Nations with high c...

ARTICLES|ONLINE FIRST Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 GBD 2021 Diseases and Injuries Collaborators Lancet Open Access Published: April 17, 2024 DOI: https://doi.org/10.1016/S0140-6736(...

Invited Commentary  June 5, 2024 Travel Guide From the Brave New World of Artificial Intelligence Daniel E. Hall JAMA Surg. Published online June 5, 2024. doi:10.1001/jamasurg.2024.1645 Just over 1 year has passed since ChatGPT (OpenAI) burst onto the scene to become the fastest growing consumer software application in history.1 It was immediately obvious that large language models (LLMs) were extraordinarily powerful, but the scope, nat...

Research Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease: multinational, longitudinal, population based, cohort study Ping Liu, Simon Sawhney, Uffe Heide-Jørgensen, et al BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2023-078063 (Published 15 April 2024)Cite this as: BMJ 2024;385:e078063 Abstract Objective To train and test a super learner strategy for ri...

Corticosteroids in Critically Ill Patients With Sepsis, ARDS and CAP In ICU Tue, 14 May 2024 Critical illness-related corticosteroid insufficiency (CIRCI) is commonly seen in criticall ill patients and involves systemic inflammation, hypothalamus–pituitary–adrenal axis dysregulation, altered cortisol metabolism, and tissue glucocorticoid resistance. A task force of international experts from the Society of Critical Care Medicine (SCCM) and the ...

Original Investigation  June 10, 2024 Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial Alain Deschamps, Arbi Ben Abdallah, Eric Jacobsohn, et al JAMA. Published online June 10, 2024. doi:10.1001/jama.2024.8144 Key Points Question  Does electroencephalography-guided anesthetic administration to minimize elect...

Editor's Note  June 3, 2024 Traditional Chinese Medicine to Prevent Type 2 Diabetes—A Difficult Path Forward Mitchell H. Katz JAMA Intern Med. Published online June 3, 2024. doi:10.1001/jamainternmed.2024.1208 Safe and effective treatments for preventing type 2 diabetes in persons at high risk for the disease are needed. In this issue of JAMA Internal Medicine, Ji and colleagues1 randomized patients with impaired glucose tolerance a...

Research Letter  February 21, 2024 Electric Bicycle Injuries and Hospitalizations Adrian M. Fernandez, Kevin D. Li, Hiren V. Patel, et al JAMA Surg. 2024;159(5):586-588. doi:10.1001/jamasurg.2023.7860 Electric bicycles (e-bicycles) are a popular consumer choice in the clean transportation revolution. Imports of e-bicycles topped 1.1 million in 2022 compared with 437 000 in 2020.1 We examined e-bicycle injuries and hospitalizations in the US fro...

Toward Greener Anaesthesia Practices: Mitigating the Environmental Impact In ICU Wed, 24 Apr 2024 Inhaled anaesthetics, including volatile hydrofluorocarbons like desflurane, sevoflurane, isoflurane, and halothane, as well as nitrous oxide (N2O), have potent greenhouse gas properties, contributing significantly to global warming and ozone layer depletion. Despite efforts to mitigate their release through gas scavenging systems, these gases are ultimate...