ICU Management & Practice, Volume 23 - Issue 1, 2023 The Footprints of a Gigantic Hound – Biomarkers in Intensive Care Biomarkers hint at the pathophysiology behind a clinical entity, leading to better treatments. Access to biomarker testing may improve drug discovery in clinical trials, responses at the bedside and personalised patient management. The human body is a construct of chemical fires – each with a characteristic smoke signal. The smoke signal...

Editorials Understanding the burden of post-covid-19 condition Qiao Wu BMJ 2023; 381 doi: https://doi.org/10.1136/bmj.p932 (Published 31 May 2023)Cite this as: BMJ 2023;381:p932 A complex picture is emerging, along with urgent priorities for future research Covid-19 cases and deaths have decreased globally,1 yet, the long term consequences of infection, including post-covid-19 condition (often known as long covid), are still being managed. Most people ...

Editorial  May 21, 2023 Conversations on Goals of Care With Hospitalized, Seriously Ill Patients Douglas B. White, Sarah K. Andersen JAMA. Published online May 21, 2023. doi:10.1001/jama.2023.8970 Goals-of-care conversations between clinicians and patients with serious illness have been shown to improve measures of patient and family well-being, while also decreasing health care costs and high-intensity treatments at the end of life.1,2 ...

EDITORIAL Video Laryngoscopy for Intubation — Time for a New Paradigm? Yonathan Freund, Ben Bloom N Engl J Med June 16, 2023DOI: 10.1056/NEJMe2305596 Endotracheal intubation — a potentially lifesaving procedure that is used for the care of many critically ill patients — demands precision, speed, and skill. It involves the placement of a tube into the trachea to protect the airways while ensuring adequate oxygenation and ventilation for patients who are in resp...

EDITORIAL A New Step in Postexposure Prophylaxis for Leprosy David M. Scollard N Engl J Med 2023; 388:1904-1905DOI: 10.1056/NEJMe2302667 Infection with Mycobacterium leprae is curable with a combination of dapsone, rifampin, and clofazimine (multidrug therapy), as recommended by the World Health Organization (WHO) in 1982. The use of this multidrug regimen led to an initial rapid decline in the global prevalence of M. leprae infection, a re...

Editorial  June 20, 2023 Revisiting the Analogy Between Clinical Trials and Diagnostic Tests by Interpreting a Negative Trial as a Negative Test for Efficacy Roger J. Lewis, Kert Viele JAMA. 2023;329(23):2023-2025. doi:10.1001/jama.2023.8972 As noted in JAMA more than 30 years ago,1 randomized clinical trials are like diagnostic tests in several ways. Clinical trials are designed to detect hypothesized treatment effects in the ...

Perspective Toward Comprehensive Care for Long Covid Janko Ž. Nikolich, Clifford J. Rosen N Engl J Med May 9, 2023DOI: 10.1056/NEJMp2304550 Three years into the Covid pandemic, SARS-CoV-2 is still with us. As the virus evolves, it continues to pose a health threat in terms of both acute infections (or reinfections) and postacute sequelae. In regard to the former, there is evidence that several pharmacologic interventions reduce the severity of infections, less...

Editorial  May 21, 2023 Conversations on Goals of Care With Hospitalized, Seriously Ill Patients Douglas B. White, Sarah K. Andersen JAMA. 2023;329(23):2021-2022. doi:10.1001/jama.2023.8970 Goals-of-care conversations between clinicians and patients with serious illness have been shown to improve measures of patient and family well-being, while also decreasing health care costs and high-intensity treatments at the end of life.1,2 Nonetheless, achi...

#ISICEM23: Low vs Standard Calorie and Protein Feeding Critical illness requiring organ support is associated with high mortality and prolonged recovery. The acute phase is characterised by anorexia, metabolic disorders, endocrine dysfunction, and hypercatabolism with muscle wasting. Nutritional support is essential during this phase. Calorie and protein deficits have been linked to higher risks of healthcare-associated infections, ICU-acquired weakness, prolonged inva...

EDITORIAL Transcatheter Therapy for Tricuspid Regurgitation — First Act Mathias Orban, Steffen Massberg N Engl J Med 2023; 388:1902-1903DOI: 10.1056/NEJMe2302457 Severe tricuspid regurgitation is associated with impaired quality of life and poor survival.1 The condition is managed medically with diuretic agents; surgery is of limited use, since many patients have a variety of coexisting conditions that increase surgical risk. Current U.S. and European soc...