Invited Commentary  August 7, 2024 Surgeon Type and Anastomotic Leaks in Ovarian Cancer Alexandra C. Istl, Nerlyne Desravines, Ugwuji N. Maduekwe JAMA Surg. Published online August 7, 2024. doi:10.1001/jamasurg.2024.2929 For patients with advanced ovarian cancer, cytoreductive surgery (CRS) and platinum-based chemotherapy are pillars of treatment.1 Optimal completeness of cytoreduction, which may necessitate multivisceral resections, aim...

CENTER-TBI - Haemoglobin Values, Transfusion Practices, Outcomes In ICU Wed, 19 Jun 2024 Severe traumatic brain injury (TBI) can cause lasting cognitive, motor, and emotional issues. Despite advances in emergency care and neurosurgery, the long-term effects of TBI remain challenging for patients, caregivers, and healthcare providers. Managing TBI focuses on preventing secondary brain injuries, which can develop hours to days after the initial trauma...

Invited Commentary  August 7, 2024 Is Too Much Oxygen a Bad Thing? Bryant Fisher, Kathirvel Subramaniam, Danny Chu JAMA Surg. Published online August 7, 2024. doi:10.1001/jamasurg.2024.2921 The current referenced double-blind randomized clinical trial by Lopez and others1 compared strategies of intraoperative hyperoxia vs normoxia during elective cardiac surgery to assess the impact on oxidative stress and clinical markers of end-organ d...

1‑h Bundle and Mortality in Patients With Suspected Sepsis In Sepsis Wed, 3 Jul 2024 Sepsis and septic shock, caused by a dysregulated response to infection, affect nearly 50 million people globally, resulting in approximately 11 million deaths. Early identification and management, including source control, antimicrobial therapy, and fluid resuscitation, are associated with reduced mortality. The Surviving Sepsis Campaign (SSC) recommends a sepsis bund...

Tele-Critical Care Nursing: The Well-Established Predecessor of Today’s Virtual Nursing Cited more than 100 times in other publications, A Second Set of Eyes: An Introduction to Tele-ICU was published by Susan Goran in 2010 (Goran 2010). Goran described “the tele-ICU is that ‘second set of eyes’ that provides additional clinical surveillance and support”. She went on to explain how inadequate nurse staffing was “linked to medication errors, increased risk of ...

Inflammatory Subphenotype and Brain Dysfunction in Mechanically Ventilated Patients In ICU Wed, 3 Jul 2024 Up to 80% of mechanically ventilated ICU patients experience acute brain dysfunction, commonly manifesting as delirium or coma. Both conditions are linked to increased mortality and long-term cognitive impairment in survivors. The underlying pathophysiology of acute brain dysfunction during respiratory failure is poorly understood.  Previo...

Novel Lipopeptide Effective Against Staphylococcus Aureus In ICU Fri, 7 Jun 2024 A novel antibacterial lipopeptide produced by the bacterium Serratia marcescens is highly effective in killing Staphylococcus aureus, one of the most significant pathogens in humans. Staphylococcus aureus is among the five most common causes of hospital-acquired infections, often leading to life-threatening infections following surgery. Since the int...

Sex Differences in SOFA Score of Sepsis Patients In Sepsis Tue, 2 Jul 2024 Sepsis is a life-threatening condition caused by a dysregulated host response to infection. The Sepsis-related Organ Failure Assessment (SOFA) score, developed in 1996, quantifies organ dysfunction across six systems: neurological, cardiovascular, respiratory, renal, liver, and coagulation. Initially specific to sepsis, the SOFA score is widely used in ICUs for daily patient mon...

Nirmatrelvir-Ritonavir for Long-COVID In ICU Sun, 9 Jun 2024 In a recent clinical trial, a 15-day course of nirmatrelvir-ritonavir targeting SARS-CoV-2 was found to be safe as an extended-duration treatment. However, it did not alleviate specific symptoms of long COVID. These findings are published in JAMA Internal Medicine. The combination of nirmatrelvir-ritonavir is approved by the FDA for treating acute COVID-19 in newly infected adults, with mi...

VV-ECMO, Prone Position and Supine MV for Hypoxaemic ARDS In ICU Tue, 11 Jun 2024 Severe acute respiratory distress syndrome (ARDS) with PaO2/FiO2 < 80 mmHg is life-threatening, and its optimal management strategy is unclear. This meta-analysis aimed to compare the effects of low tidal volumes (Vt), moderate Vt, prone ventilation, and venovenous extracorporeal membrane oxygenation (VV-ECMO) on mortality in severe ARDS. Study researchers conducted...