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Effect of a quality improvement intervention with daily round checklists, goal setting, and clinician prompting on mortality of critically ill patients: a randomized clinical trial. ICM Index Number: 23/070 Authors: Writing Group for the CHECKLIST-ICU Investigators and the Brazilian Research in Intensive Care Network (BRICNet) et al. Reference: JAMA 2016;315:1480–1490. Trial registration number: NCT01785966. © American Medical Association. ICM ABSTRACT Objective To det...
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Trial of decompressive craniectomy for traumatic intracranial hypertension. ICM Index Number: 23/069 Authors: Hutchinson PJ, Kolias AG, Timofeev IS et al. Reference: N Engl J Med 2016;375:1119–1130. Trial registration number: ISRCTN66202560. © Massachusetts Medical Society. ICM ABSTRACT Objective To assess the effectiveness of craniectomy as a last-tier intervention in patients with traumatic brain injury (TBI) and refractory intracranial hypertension. Introduction Int...
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Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. ICM Index Number: 23/068 Authors: Su X, Meng ZT, Wu XH et al. Reference: Lancet 2016;388:1893-1902. Trial registration number: ChiCTR-TRC-10000802. © Elsevier Ltd. ICM ABSTRACT Objective To investigate whether prophylactic, low-dose dexmedetomidine could safely decrease the incidence of delirium in elderly patients admitted to ...
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Does Dexmedetomidine Reduce Delirium by Improving Sleep? Xian Su, MD; Dongxin Wang; MD ICU Management & Practice 2016; 16(4) Delirium is a common complication in intensive care unit (ICU) patients and its occurrence is associated with worse outcome (Inouye et al. 2014; Abelha et al. 2013). Sleep disturbances are considered one of the important risk factors of delirium development (Flink et al. 2012). Recent evidence shows that dexmedetomidine, either at sedative or n...
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Effect of palliative care-led meetings for families of patients with chronic critical illness: A randomized clinical trial. ICM Index Number: 23/059 Authors: Carson SS, Cox CE, Wallenstein S et al. Reference: JAMA 2016;316:51–62. Trial registration number: NCT01230099. © American Medical Association. ICM ABSTRACT Objective To determine whether support meetings led by palliative care clinicians improve anxiety and depression in decision makers acting on behalf of chroni...
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High-dose perioperative atorvastatin and acute kidney injury following cardiac surgery: a randomized clinical trial. ICM Index Number: 23/060 Authors: Billings FT IV, Hendricks PA, Schildcrout JS et al. Reference: JAMA 2016;315:877–888. Trial registration number: NCT00791648. © American Medical Association. ICM ABSTRACT Objective To test the hypothesis that short-term, high-dose perioperative atorvastatin reduces acute kidney injury (AKI) following cardiac surgery. Int...
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Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure: A randomized clinical trial. ICM Index Number: 23/058 Authors: Morris PE, Berry MJ, Files DC et al. Reference: JAMA 2016;315:2694–2702. Trial registration number: NCT00976833. © American Medical Association. ICM ABSTRACT Objective To determine whether early delivery of a standardized, multifaceted ICU and hospital rehabilitation programme might decrease hospital lengt...
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Medscape Critical Care > Critical Issues Ultrasound to Assess Volume Status--Why Bother? Aaron B. Holley, MD November 14, 2016 Volume Assessment by Bedside Debate 床旁评估容量的争论 Indulge me and imagine that you are on intensive care unit rounds at an academic hospital. You are discussing a patient who is mechanically ventilated, hypotensive, and on vasopressors. Your team is sure that the patient is septic, but he has already had aggressive resuscitation with fluids...
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Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial. ICM Index Number: 23/064 Authors: Sierink JC, Treskes K, Edwards MJ et al. Reference: Lancet 2016;388:673-683. Trial registration number: NCT01523626. © Elsevier Ltd. ICM ABSTRACT Objective To assess the effect of total-body CT scanning compared with the standard work-up on in-hospital mortality in trauma patien...
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Intensive blood-pressure lowering in patients with acute cerebral hemorrhage. ICM Index Number: 23/056 Authors: Qureshi AI, Palesch YY, Barsan WG et al. Reference: N Engl J Med 2016;375:1033-1043. Trial registration number: NCT01176565. © Massachusetts Medical Society. ICM ABSTRACT Objective To investigate whether reducing systolic (BP) earlier than in previous trials would show greater therapeutic benefit in patients with intracerebral haemorrhage (ICH). Introduction ...
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