#LIVES2023: Magnesium Sulphate in Patients with Thrombotic Thrombocytopaenic Purpura Previous research has indicated the potential benefits of using magnesium sulphate in thrombotic thrombocytopaenic purpura (TTP) treatment. The goal of the Magnesium sulphate in patients with thrombotic thrombocytopenic purpura (MAGMAT) study was to assess the impact of magnesium sulphate supplementation on the recovery of patients with TTP. This was a multicentre study invo...

Invited Commentary  November 15, 2023 Who Looks Like a Surgeon?—Evaluating Reflections From a Digital Mirror Rebecca Sorber, M. Libby Weaver JAMA Surg. Published online November 15, 2023. doi:10.1001/jamasurg.2023.5705 As the number of publicly available tools using artificial intelligence (AI) has rapidly expanded, innumerable attempts to find beneficial applications for such tools in medicine follow close behind.1 Perhaps one of the mo...

#LIVES2023: Initiation of CRRT versus IHD In critically ill patients with acute kidney injury (AKI), renal replacement therapy (RRT) is often necessary. The choice of RRT modality, such as intermittent haemodialysis (IHD) or continuous renal replacement therapy (CRRT), has been a subject of debate. IHD involves shorter, more frequent sessions, while CRRT is continuous and slower. CRRT is generally preferred for haemodynamically unstable patients, while IHD is used ...

ICU Management & Practice, Volume 22 - Issue 5, 2022 Improving Haemodynamic Management of ICU Patients: Decatecholaminisation & Cardiac Stress Reduction  summary of a symposium organised by AOP Health with presentations from Ricard Ferrer, Vall d’Hebron University Hospital, Barcelona, Spain; Bruno Levy, Centre Hospitalier Universitaire de Nancy, CHU Nancy · Réanimation Médicale Brabois, France; and Michael Fries, St. Vincenz Krankenhaus Limburg, De...

Editorial  November 29, 2023 The Value of Not Intubating Comatose Patients With Acute Poisoning Zaffer Qasim, Jeanmarie Perrone, M. Kit Delgado JAMA. Published online November 29, 2023. doi:10.1001/jama.2023.22462 Imagine if a new multicenter, randomized trial of a pharmaceutical drug found that for every 3 patients treated on presentation to the hospital with a common severe illness, one intubation and an intensive care unit (ICU) admission ...

IMMUNOCITRE Trial - Enteral L-citrulline Administration vs Placebo Critically ill patients admitted to the ICU often experience temporary immune deficiencies, leading to persistent organ dysfunction and a higher risk of ICU-acquired infections. Researchers have been exploring immune-enhancing diets to address these issues, focusing on nutrients like L-arginine. L-arginine is important because it can become deficient in critically ill patients and is associated with...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Cardiovascular Management in Sepsis: Improving Cardiac and Vascular Functions Vasopressin and landiolol are critical therapies for ensuring the vascular and cardiac systems are as close to optimal conditions as possible during septic shock. Better cardiovascular management in septic shock can help improve septic shock management. Sepsis is a life-threatening organ dysfunction caused by a dysregulated h...

ECLS in Infarct-Related Cardiogenic Shock Extracorporeal life support (ECLS) is used frequently in treating infarct-related cardiogenic shock, but there is a lack of evidence regarding its impact on mortality. In a multicentre trial involving patients with acute myocardial infarction complicated by cardiogenic shock and planned early revascularisation, participants were randomly assigned to receive ECLS along with standard medical treatment (ECLS group) or stand...

Genetically Predicted Insomnia and Risk of Sepsis Insomnia, a common sleep disorder, has been linked to various adverse health outcomes, including altered immune function and elevated systemic levels of inflammatory markers, which may affect women more than men. Dysregulated immune responses can lead to conditions like sepsis, which has high morbidity and mortality. A study was conducted to determine if insomnia is associated with risk of sepsis. Researchers als...

ICU Management & Practice, Volume 23 - Issue 2, 2023 Sustainability and Extracorporeal Organ Support Extracorporeal organ support (ECOS) involves an extensive use of healthcare resources and clinical problem-solving challenges. The feasibility of applying known ecological analysis and sustainability strategies in healthcare need to be started in this setting. Introduction As with any other species, human activity modifies the environment at multiple l...