Editor's Note  January 8, 2024 Protecting Patients by Reducing Diagnostic Error Grace Y. Zhang, Cary P. Gross JAMA Intern Med. Published online January 8, 2024. doi:10.1001/jamainternmed.2023.7334 Almost a decade after the release of “Improving Diagnosis in Health Care,” the National Academies of Sciences, Engineering, and Medicine report that highlighted the imperative to improve the diagnostic process in health care, diagnostic errors conti...

Uncovering Heterogeneity in Sepsis Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite progress in understanding its underlying mechanisms, there's no specific successful treatment for sepsis. Precision therapy is needed, and understanding the heterogeneity of sepsis is crucial. Recent methods have attempted to measure sepsis heterogeneity using various computational approaches on clinical, biomarker, or gene expre...

Redefining Acute Respiratory Distress Syndrome Acute Respiratory Distress Syndrome (ARDS) has been known for over a century but was officially described in 1967. Despite revisions in its definition, there's ongoing debate about whether ARDS is a distinct medical condition. The current diagnostic criteria for ARDS are challenging to apply in clinical practice, so standardising the assessment of pulmonary and extrapulmonary involvement is needed for more personalised...

Medical News & Perspectives  January 31, 2024 Paxlovid Is Effective but Underused—Here’s What the Latest Research Says About Rebound and More Rita Rubin JAMA. Published online January 31, 2024. doi:10.1001/jama.2023.28254 Anyone who watches television has probably seen the Pfizer commercial with the tagline, “If it’s COVID, Paxlovid.” That might be a catchy slogan, but, apparently, a lot of people aren’t getting the message. The...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Neonatal Extracorporeal Membrane Oxygenation Xenios sponsored a lunch symposium at the 16th European Conference on Paediatric and Neonatal Ventilation (EPNV) in Montreux (CH) in May 2023. Matteo Di Nardo (Italy) introduced the audience to extracorporeal membrane oxygenation (ECMO) in neonates. Florian Kipfmüller (Germany) presented current knowledge and his experience with ECMO in neonates with congenital...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Transforming a PICU in the Digital Age Digitalisation is ultimately the driving force behind digital transformation. It will take us from a reactive healthcare system to a proactive one that focuses on prediction and prevention. Introduction The digital transformation has left a few things untouched in recent years, radically changing healthcare management for citizens, professionals, and public hea...

CHEST COMMENTARY| VOLUME 165, ISSUE 1, P16-18, JANUARY 2024Download Full Issue Upcoming Clinical Trials in Critical Care, Diffuse Lung Disease, Pulmonary Vascular Disease, and Thoracic Oncology in 2024 Adam Edward Lang, Michael N. Kammer, Aravind Menon, et al Chest 2024; 165: 16-18 DOI:https://doi.org/10.1016/j.chest.2023.07.029 Abbreviations:  CTEPH (chronic thromboembolic pulmonary hypertension), IPF(idiopathic pulmonary f...

American Thoracic Society Guideline Update for Patients with ARDS ARDS is a life-threatening respiratory failure characterised by acute hypoxaemia and bilateral radiographic infiltrates. The definition of ARDS has evolved over 50 years, with recent suggestions to include intubated and non-intubated patients. Management remains largely supportive, focusing on strategies to limit lung injury, but high mortality rates persist, and survivors often face long-term impair...

Editorial  January 21, 2024 Transitioning From SIRS to Phoenix With the Updated Pediatric Sepsis Criteria: The Difficult Task of Simplifying the Complex Roberto Jabornisky, Nathan Kuppermann, Sebastián González-Dambrauskas JAMA. Published online January 21, 2024. doi:10.1001/jama.2023.27988 Everyone must acknowledge the difficulty of distinguishing diseases…whoever denies this may as well deny that there is such a thing as medical art. Wi...

Invited Commentary  December 13, 2023 Fertility, Family, and a Career in Surgery—Time to Change the Narrative J. Elaine Tang, Melina C. Vassiliou, Liane S. Feldman JAMA Surg. Published online December 13, 2023. doi:10.1001/jamasurg.2023.6397 Medical training usually falls within the window of optimal fertility for most trainees.1 Operating within the rigid confines of residency programs, the perceived realities of family planning can str...