[ICU Management & Practice]: 脓毒症的抗氧化及抗炎治疗已关闭评论
Antioxidant, Anti-inflammatory Therapy in Sepsis
Sepsis is associated with long-term cognitive impairment and poor psychological and functional outcomes. Potential mechanisms for this include intracerebral oxidative stress and inflammation. However, there is limited knowledge about the effects of early antioxidant and anti-inflammatory therapy on cognitive, psychological, and functional outcomes in sepsis survivors.
The Vitamin C, Thiamine, and Steroids in Sepsi...
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[Lancet Infect Dis发表述评]:尽管细菌感染风险很低,但新冠病毒感染患者使用了太多的抗生素已关闭评论
COMMENT|ONLINE FIRST
Too many antibiotics for patients with COVID-19 despite low bacterial infections
Daniele Roberto Giacobbe, Matteo Bassetti
Lancet Infect Dis Published:January 27, 2023
DOI:https://doi.org/10.1016/S1473-3099(22)00866-0
Although low rates of bacterial infections have frequently been reported in patients hospitalised with COVID-19, excessive use of antibiotics has also been described in this population since the beginning of the COVID-19 p...
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[ICU Management & Practice]: 创伤后出血及凝血功能障碍的欧洲诊疗指南已关闭评论
European Guidelines: Management of Bleeding, Coagulopathy Following Trauma
According to the Global Burden of Diseases, Injuries, and Risk Factors Study, trauma accounted for 8% of total deaths annually. Among adolescents aged 10-24 years, road injuries, self-harm, and interpersonal violence are the top causes of disability-adjusted life-years, and road injuries are ranked first in the 25-49 year age group. Post-traumatic bleeding and associated traumatic coagulopat...
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[ICU Management & Practice]: 儿童院外心跳骤停时医生在场已关闭评论
Prehospital Physician Presence During Paediatric OHCA
A study was conducted to investigate whether the presence of prehospital physicians affected the neurological outcomes of paediatric patients who experienced an out-of-hospital cardiac arrest (OHCA). The study included paediatric patients who were 17 years old or younger and were registered in a database between June 2014 and December 2019.
The researchers used logistic regression models and stabil...
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[ICU Management & Practice]: 颅脑创伤及卒中患者的早期与晚期气管切开已关闭评论
Early Tracheostomy vs Late Tracheostomy in Traumatic Brain Injury, Stroke
A recent review aimed to determine whether early tracheostomy benefits patients with severe traumatic brain injury (TBI) and stroke and whether these benefits persist across different underlying conditions.
The included studies in the review were those written in English, French, Spanish, or Portuguese and with a formulated question that compared outcomes between early and late tracheostom...
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[ICU Management & Practice]: 确诊脑死亡已关闭评论
Determining Brain Death
The Uniform Law Commission (ULC) created the Uniform Determination of Death Act (UDDA) in the United States in 1980, which was adopted by all 50 states. The UDDA defines death as either the irreversible cessation of circulatory and respiratory functions or the irreversible cessation of all functions of the entire brain, including the brainstem. While the loss of cardiorespiratory function has always been recognised as death, some view the de...
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[ICU Management & Practice]: 运送AED的无人机已关闭评论
Drones Delivering Automated External Defibrillators
Out-of-Hospital Cardiac Arrest (OHCA) is a dangerous condition with high mortality and poor health outcomes. According to the International Liaison Committee for Resuscitation (ILCOR), the global incidence of OHCA treated by emergency medical services (EMS) is 30.0-97.1 per 100,000 population, with discharge/30-day survival rates of 3.1-20.4% and good neurological outcomes of 2.8±18.2%. OHCA incidence in Europe is...
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[JAMA医学新闻]:从证据到行为改变平均需要17年—实施科学这一新兴领域寻求加速已关闭评论
Medical News & Perspectives
April 5, 2023
It Takes an Average of 17 Years for Evidence to Change Practice—the Burgeoning Field of Implementation Science Seeks to Speed Things Up
Rita Rubin
JAMA. Published online April 5, 2023. doi:10.1001/jama.2023.4387
Colorectal cancer screening with an at-home stool test is more convenient than with a colonoscopy, but an abnormal result on the former still requires a follow-up with the latter.
...
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[ICU Management & Practice]: 感染性休克的远处缺血处理已关闭评论
Remote Ischaemic Conditioning in Septic Shock
Septic shock is one of the most severe complications of any infection. It affects millions of people each year. Studies show that in the U.S. and Europe, nearly 10% of patients admitted to the ICU have septic shock. Significant efforts have been made to recognise and treat septic shock early. Still, over 50% of patients die of septic shock within days or weeks after diagnosis. Thus, there is a need for new therapeutic a...
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[JAMA发表述评]:肾素—血管紧张素系统抑制剂治疗新冠病毒感染没有获益已关闭评论
Editorial
April 11, 2023
Lack of Benefit of Renin-Angiotensin System Inhibitors in COVID-19
Matthew M. Y. Lee, John J. V. McMurray
JAMA. 2023;329(14):1155-1156. doi:10.1001/jama.2023.4405
There has been considerable interest in the potential role of renin-angiotensin system (RAS) inhibitors in patients with COVID-19 given that angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2.1 Because ACE inhibitors and angiot...
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