News & Perspective > Critical Issues Which Score to Use When Screening for Sepsis on the Wards Aaron B. Holley, MD April 21, 2017 Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients Outside the Intensive Care Unit Churpek MM, Snyder A, Han X, et al Am J Respir Crit Care Med. 2017;195:906-911 Background 背景 The Sepsis-3 consensus statement recom...

Blood Donor Age, Sex Do Not Affect Outcomes After All Diana Swift April 27, 2017 Blood donor age and sex are not associated with recipient survival, and are therefore not relevant to donated blood allocation, according to a Scandinavian study of almost 1 million transfusions. 斯堪的纳维亚一项对将近100万名输血患者的研究显示，献血者年龄和性别与接受输血患者的生存率并不相关，因此，在分配血液时无需考虑上述因素。 The new findings, published online April 24 in JAMA Internal M...

Original Investigation April 24, 2017 Association of Donor Age and Sex With Survival of Patients Receiving Transfusions Gustaf Edgren, Henrik Ullum, Klaus Rostgaard, et al JAMA Intern Med. Published online April 24, 2017. doi:10.1001/jamainternmed.2017.0890 Importance 背景 Following animal model data indicating the possible rejuvenating effects of blood from young donors, there have been at least 2 observational studies conducted with humans that have investigated w...

Recommended Reading from the NewYork-Presbyterian Hospital – Weill Cornell Medicine Pulmonary and Critical Care Medicine Fellows Kevin C. Ma, Daniel S. Jones, David R. Price, et al AJRCCM Articles in Press. Published on 13-March-2017 as 10.1164/rccm.201612-2478RR Neto AS, et al. Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual pa...

Recommended Reading from the NewYork-Presbyterian Hospital – Weill Cornell Medicine Pulmonary and Critical Care Medicine Fellows Kevin C. Ma, Daniel S. Jones, David R. Price, et al AJRCCM Articles in Press. Published on 13-March-2017 as 10.1164/rccm.201612-2478RR Dickson et al. Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome. Nat Microbio (8) Reviewed by Daniel S. Jones Acute respiratory distress syndrome (ARDS) is...

Recommended Reading from the NewYork-Presbyterian Hospital – Weill Cornell Medicine Pulmonary and Critical Care Medicine Fellows Kevin C. Ma, Daniel S. Jones, David R. Price, et al AJRCCM Articles in Press. Published on 13-March-2017 as 10.1164/rccm.201612-2478RR Kor DJ. Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA (1) Reviewed by Kevin C. Ma Acute respiratory distress syndr...

Editorial March 21, 2017 Optimizing the Settings on the Ventilator Settings: High PEEP for All? Ary Serpa Neto, Marcus J. Schultz JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2570 Mechanical ventilation is an effective life-support technique widely deployed across a variety of clinical settings in the care of many millions of patients each year worldwide. However, it is not a panacea. A central issue is that artificial ventilation works by pushing air ...

EMPIRICAL MICAFUNGIN TREATMENT AND SURVIVAL WITHOUT INVASIVE FUNGAL INFECTION IN ADULTS WITH ICU-ACQUIRED SEPSIS, CANDIDA COLONIZATION, AND MULTIPLE ORGAN FAILURE: 
THE EMPIRICUS RANDOMIZED CLINICAL TRIAL. Authors: Timsit JF, Azoulay E, Schwebel C, et al. Reference: JAMA 2016;316:1555–1564. © American Medical Association. Level of evidence: 2 ICM ABSTRACT Objective To determine the effect of empirical micafungin treatment on survival without an invasive fungal infection i...

Medscape Critical Care > Critical Issues How to Interpret a Diffusion Capacity of the Lung for Carbon Monoxide Aaron B. Holley, MD March 07, 2017 Background The diffusion capacity of the lung for carbon monoxide (DLCO) is used to measure the body's ability to transfer oxygen across the alveolar-capillary membrane. [1] Internists use this test to identify interstitial lung disease, oncologists order it to assess the effects of chemotherapy, and pulmonologists use it f...

EPIDEMIOLOGY OF ACUTE KIDNEY INJURY IN CRITICALLY ILL CHILDREN AND YOUNG ADULTS. Authors: Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL for the AWARE Investigators. Reference: N Engl J Med, 2017; 376: 11-20 © Massachusetts Medical Society. Level of evidence: 4 ICM ABSTRACT Objective To define the incremental risk of death and complications associated with severe acute kidney injury (AKI) in critically ill children and young adults. Introduction In adult patients, AKI is ...