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CORRESPONDENCE Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis N Engl J Med 2017; 377:994-995 DOI: 10.1056/NEJMc1708979 To the Editor: 致编辑 In reporting the results of their meta-analysis of individual patient data from three trials, the Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM) investigators (June 8 issue)1 conclude that early, goal-directed therapy (EGDT) did not result in better outcomes than usual care in the resuscit...
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EPIC III: ICU感染患病率研究 EPIC III: The Extended Study on Prevalence of Infection in Intensive Care   参加EPIC III研究的步骤 1. 登陆网站: 请登陆以下网址:www2.intensive.org/EPIC3/home.asp 2. 注册您所在的ICU相关信息 包括ICU名称,ICU床位数,收治患者人数,ICU种类等。 注册时间不迟于9月14日。 3. 下载CRF 您可在网站通过链接下载中文版CRF。 4. 入选患者 研究当日(9月13日)在ICU接受治疗的所有患者均入选。 5. 收集资料 EPIC III研究收集的大多数资料均为研究当日的临床及实验室检查结...
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ORIGINAL ARTICLE Oxygen Therapy in Suspected Acute Myocardial Infarction Robin Hofmann, M.D., Stefan K. James, M.D., Ph.D., Tomas Jernberg, M.D., Ph.D., Bertil Lindahl, M.D., Ph.D., David Erlinge, M.D., Ph.D., Nils Witt, M.D., Ph.D., Gabriel Arefalk, M.D., Mats Frick, M.D., Ph.D., Joakim Alfredsson, M.D., Ph.D., Lennart Nilsson, M.D., Ph.D., Annica Ravn-Fischer, M.D., Ph.D., Elmir Omerovic, M.D., Ph.D., Thomas Kellerth, M.D., David Sparv, B.Sc., Ulf Ekelund, M.D., Ph.D., R...
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Special Article Collection Sepsis Awareness Month We are pleased to present a new Special Article Collection focused on sepsis, drawing together a selection of recently published articles from CHEST in recognition of Sepsis Awareness Month. Selected articles are freely available to access throughout the month of September. Hydrocortisone and Ascorbic Acid Synergistically Prevent and Repair Lipopolysaccharide-Induced Pulmonary Endothelial Barrier Dysfunc...
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EPIC III: ICU感染患病率研究 EPIC III: The Extended Study on Prevalence of Infection in Intensive Care   参加EPIC III的理由 权威研究: 于1992年和2007年前后进行的EPIC及EPIC II研究,其主要研究结果发表在JAMA,为了解全球各国ICU中感染患者的基本特征及预后提供了翔实的第一手资料。 内容丰富: EPIC II的研究内容不仅涉及所有感染患者的一般特征,而且针对MRSA感染、念珠菌血症、老年危重病患者的感染、肝硬化患者、腹腔感染、低钠及高钠血症流行病学、细菌耐药等问题进行了后续的研究,共发表论...
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Comment International Surviving Sepsis Campaign guidelines 2016: the perspective from low-income and middle-income countries Gentle S Shrestha, Arthur Kwizera, Ganbold Lundeg, et al Lancet Infect Dis 2017; 17: 893-895 In the most recent international Surviving Sepsis Campaign guidelines, Rhodes and colleagues1excellently outline evidence-based management of patients with sepsis and septic shock. Of note, however, is that most of the world's population resides in low-income...
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Fluid Challenge: Its Impact on Fluid Responsiveness The fluid challenge is considered the gold standard for diagnosis of fluid responsiveness. A new systematic review finds that the duration of the fluid infusion in a fluid challenge has a significant influence on fluid responsiveness – i.e., a rapid infusion increases the proportion of patients with a positive response. However, the type and volume of fluid or the time of assessment does not appear to have any effect o...
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[编者按]:2017年4月8日,我们在网站上介绍了JAMA在线发表的RCT结果:肺保护性通气基础上肺复张对术后肺部并发症的影响。近日,JAMA刊登了两封读者来信,对该研究结果提出了自己的看法。 Comment & Response August 15, 2017 Alveolar Recruitment Strategies After Cardiac Surgery—Reply Marcelo B. P. Amato, Marcia S. Volpe, Ludhmila A. Hajjar JAMA. 2017;318(7):668-669. doi:10.1001/jama.2017.8697 In Reply Drs Li and Shi raised concerns about which of our study groups actually provided...
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Preliminary Communication August 22/29, 2017 Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial Ajit P. Limaye, Renee D. Stapleton, Lili Peng, et al. JAMA. 2017;318(8):731-740. doi:10.1001/jama.2017.10569 Abstract Importance 背景 The role of cytomegalovirus (CMV) reactivation in mediating adverse clinical outcomes in nonimmunosuppressed adults with critical illness is unknown. 对于无免疫功...
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