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Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study Rudy Sinharay, Jicheng Gong, Benjamin Barratt, et al Lancet 2017 Published online December 5, 2017 http://dx.doi.org/10.1016/ S0140-6736(17)32643-0 Summary Background Long-term exposure to pollution can lead t...
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IDSA POSITION STATEMENT:  Why IDSA Did Not Endorse the Surviving Sepsis Campaign Guidelines David N. Gilbert, Andre C. Kalil, Michael Klompas, Henry Masur, Dean L. Winslow, for IDSA Sepsis Task Force Clinical Infectious Diseases, cix997, https://doi.org/10.1093/cid/cix997 Published: 22 November 2017 摘要: IDSA 不赞成2016 年SCCM 的脓毒症指南。关于脓毒症指南的推荐意见,IDSA 和 SCCM 进行过多次友好的讨论。我们协会对于SCCM 指南中纳入的支持其推荐意见的研究结果有不同解读,...
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Original Investigation December 19, 2017 Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections Jeffrey S. Gerber, Rachael K. Ross, Matthew Bryan, et al JAMA. 2017;318(23):2325-2336. doi:10.1001/jama.2017.18715 Abstract Importance 背景 Acute respiratory tract infections account for the majority of antibiotic exposure in children, and broad-spectrum antibiotic...
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Intensive Care Medicine ONLINE FIRST THIS WEEK Original ~ Claude Guérin et al. A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study. Systematic Review ~ François Lamontagne et al. Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock. Original ~ Luregn J. Schlapbach et al. Prognostic accuracy of age-adapted SOFA, SIRS,...
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Perspective > Viewpoints COMMENTARY What We Can Learn From Treating Sepsis in Low-Resource Settings Gregory S. Martin, MD, MSc December 08, 2017 Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial Andrews B, Semler MW, Muchemwa L, et al JAMA. 2017;318:1233-1240 Study Summary Early and targeted sepsis resuscitation[1] has become the cornerstone of effective sepsis therapy,[2,3] yet...
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Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial Guy E Thwaites, Matthew Scarborough, Alexander Szubert, et al Lancet 2017 online first DOI: http://dx.doi.org/10.1016/S0140-6736(17)32456-X Summary Background 背景 Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampici...
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Estimates of global seasonal influenza-associated respiratory mortality: a modelling study A Danielle Iuliano, Katherine M Roguski, Howard H Chang, et al Lancet 2017 online first DOI: http://dx.doi.org/10.1016/S0140-6736(17)33293-2 Summary Background 背景 Estimates of influenza-associated mortality are important for national and international decision making on public health priorities. Previous estimates of 250 000–500 000 annual influenza deaths are outdated. We update...
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Original Investigation December 12, 2017 Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer Babak Ehteshami Bejnordi, Mitko Veta, Paul Johannes van Diest, et al. JAMA. 2017;318(22):2199-2210. doi:10.1001/jama.2017.14585 Abstract Importance 背景 Application of deep learning algorithms to whole-slide pathology images can potentially improve diagnostic accuracy and efficiency. 对全片病理图像应用深度学习...
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News > Reuters Health Information Prolonged Beta-lactam Infusion Better for Patients With Sepsis By Will Boggs MD December 04, 2017 NEW YORK (Reuters Health) - Mortality in patients with sepsis is lower for those who receive prolonged intravenous infusions of antipseudomonal beta-lactams than for those who receive short-term infusions, according to a systematic review and meta-analysis of randomized trials. "In a previous meta-analysis published in 2013 in Clinica...
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News Influenza Activity Increasing in United States, CDC Says Lara C. Pullen, PhD December 11, 2017 Influenza activity has increased since early November, according to the influenza activity update from the Centers for Disease Control and Prevention (CDC), published in the December 8 issue of the Morbidity and Mortality Weekly Report. Although the United States had low levels of influenza activity in October, several influenza activity indicators are now higher than is ...
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