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JAMA Insights November 23, 2020 Diagnosis, Management, and Pathophysiology of Arterial and Venous Thrombosis in COVID-19 Gregory Piazza, David A. Morrow JAMA. 2020;324(24):2548-2549. doi:10.1001/jama.2020.23422 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with arterial and venous thrombotic complications. In a US registry of patients with coronavirus disease 2019 (COVID-19), thrombotic complications occurred in 2.6%...
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Editorials Remdesivir: a pendulum in a pandemic lan S Schwartz, Emily L Heil, Erin K McCreary BMJ 2020; 371: m4560 doi: https://doi.org/10.1136/bmj.m4560 (Published 24 November 2020) New guidance challenges remdesivir use for patients with covid-19 Covid-19 has claimed over a million lives globally and devastated healthcare systems, economies, and societal welfare. Determining effective, safe, and scalable prevention and treatment measures is the top priori...
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Research Letter December 22/29, 2020 Uptake and Accuracy of the Diagnosis Code for COVID-19 Among US Hospitalizations Sameer S. Kadri, Jake Gundrum, Sarah Warner, et al JAMA. 2020;324(24):2553-2554. doi:10.1001/jama.2020.20323 Administrative claims may provide an understanding of the clinical and economic burden of novel coronavirus disease 2019 (COVID-19). However, their limited sensitivity in identifying conditions, such as sepsis,1 sugge...
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Original Investigation November 24, 2020E20-260 200-101 Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial Suzanne Schuh, Judy Sweeney, Maggie Rumantir, et al JAMA  2020;324(20):2038-2047. doi:10.1001/jama.2020.19839 Abstract Importance While intravenous magnesium decreases h...
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Feature Christmas 2020: The Citadel Harms and the Xmas factor Robin E Ferner, Jeffrey K Aronson BMJ 2020; 371: m4067 (Published 16 December 2020) doi: https://doi.org/10.1136/bmj.m4067 The Christmas season is associated with preventable harms from cards, tree decorations, and presents, as well as overeating and overdrinking. Given the balance of benefits and harms, Christmas may not be cost effective. We hope you’re well, that you’ve posted the last of...
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FeatureHPE6-A44 HPE6-A43 Covid-19: What now for remdesivir? Jeremy Hsu BMJ 2020; 371: m4457 doi: https://doi.org/10.1136/bmj.m4457 (Published 20 November 2020) The spectre of past pandemics looms large over remdesivir, one of the first drug treatments for covid-19. With a WHO trial finding little benefit, Jeremy Hsu asks if the expensive drug is just Tamiflu redux? It’s a cautionary tale worth remembering amid the coronavi...
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CORRESPONDENCECRISC C2090-611 Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer Teresa Aydillo, Ana S. Gonzalez-Reiche, Sadaf Aslam, et al N Engl J Med December 1, 2020DOI: 10.1056/NEJMc2031670 TO THE EDITOR: Detection of replication-competent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most reliable indicator of contagiousness.1 Although the duration of live-virus shedding is well-characterized in immunoc...
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ONLINE FIRST THIS WEEK(FREE ACCESS) Review ~ Demoule A. et al. - How to ventilate obstructive and asthmatic patients Review ~ Guérin C. et al. - Prone position in ARDS patients: why, when, how and for whom Review ~ Chanques G. et al. - Analgesia and sedation in patients with ARDSConference Reports and Expert Panel ~ Robba C. et al. - Mechanical ventilation in patients with acute b...
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ORIGINAL ARTICLE REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19 David M. Weinreich, Sumathi Sivapalasingam, Thomas Norton, et al N Engl J Med December 17, 2020DOI: 10.1056/NEJMoa2035002 Abstract BACKGROUND Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads. METHODS In this ongoing, double-blind, phase 1–3 trial involving nonhospitalized patients wit...
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Research Christmas 2020: House of God Estimating my equilibrium energy intake during lockdown: very introspective study R A Lewis BMJ 2020; 371: m4561 (Published 16 December 2020) doi: https://doi.org/10.1136/bmj.m4561 Abstract Objective To estimate the daily dietary energy intake for me to maintain a constant body weight. How hard can it be? Design Very introspective study. Setting At home. In lockdown. (Except every Tuesday afternoon a...
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