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ORIGINAL ARTICLE Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care Lia Bally, Hood Thabit, Sara Hartnell, et al N Engl J Med 2018; 379:547-556 DOI: 10.1056/NEJMoa1805233 Abstract BACKGROUND 背景 In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing evidence that a closed-loop delivery system (artificial pancreas) can improve glucose control in patients with type 1 diabetes. We want...
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Articles Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial Hunter B Moore, Ernest E Moore, Michael P Chapman, et al Lancet 2018; 392: 283-291 Summary Background 背景 Plasma is integral to haemostatic resuscitation after injury, but the timing of administration remains controversial. Anticipating approval of lyophilised plasma by the US Food and Drug Administration, the US Department of Defe...
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ORIGINAL ARTICLE A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus Wiebke Fenske, Julie Refardt, Irina Chifu, et al N Engl J Med 2018; 379:428-439 DOI: 10.1056/NEJMoa1803760 Abstract BACKGROUND 背景 The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation tes...
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CORRESPONDENCE Mobile Automated External Defibrillator Response System during Road Races Tomoya Kinoshi, Shota Tanaka, Ryo Sagisaka, et al N Engl J Med 2018; 379:488-489 DOI: 10.1056/NEJMc1803218 TO THE EDITOR: The number of marathon races and other road races has rapidly increased in Japan,1 as have the number of sudden cardiac arrests during these races.2 We developed a rapid mobile automated external defibrillator (AED) system to provide early cardiopulmonary resuscitat...
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ORIGINAL ARTICLE Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock Jason L. Sperry, Francis X. Guyette, Joshua B. Brown, et al N Engl J Med 2018; 379:315-326 DOI: 10.1056/NEJMoa1802345 Abstract BACKGROUND 背景 After a person has been injured, prehospital administration of plasma in addition to the initiation of standard resuscitation procedures in the prehospital environment may reduce the risk of downstream complications from...
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Original Investigation July 24/31, 2018 Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis Idris V. R. Evans, Gary S. Phillips, Elizabeth R. Alpern, et al JAMA. 2018;320(4):358-367. doi:10.1001/jama.2018.9071 Abstract Importance 背景 The death of a pediatric patient with sepsis motivated New York to mandate statewide sepsis treatment in 2013. The mandate included a 1-hour bundle of blood cultures, broad-spectrum antibi...
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JAMA Clinical Evidence Synopsis July 19, 2018 Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics Joshua Z. Goldenberg, Dominik Mertz, Bradley C. Johnston JAMA. Published online July 19, 2018. doi:10.1001/jama.2018.9064 Clinical Question In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficileinfection without an increase in adverse events? ...
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Perspective > Medscape Pharmacists > Ask the Pharmacists Tight Blood Glucose Control in Cardiac Surgery Patients Alyson P. Lozicki, PharmD July 20, 2018 Question: Does intensive, perioperative glucose control benefit patients with or without diabetes undergoing cardiac surgery? Response from Expert Alyson P. Lozicki, PharmD Drug Information Research Fellow Perioperative hyperglycemia (occurring intraoperatively or in the immediate postoperative period) develops in...
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News > Medscape Medical News Updated TAVR Consensus Document Highlights Quality, Not Just Volume Marlene Busko July 20, 2018 Four cardiology societies issued a joint statement for requirements for centers with existing or new transcatheter aortic valve replacement (TAVR) programs, which updates a 2012 statement. The new document is part of a transition away from using the volume of procedures performed to the quality of patient outcomes to measure TAVR-center perform...
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Perspective > Society for Healthcare Epidemiology of America (SHEA) > Expert Commentaries COMMENTARY Multidrug-Resistant Infections: What's on the Horizon? Jasmine R. Marcelin, MD July 18, 2018 Ceftazidime-Avibactam Resistance 头孢他啶-阿维巴坦耐药 Ceftazidime-avibactam is approved by the US Food and Drug Administration (FDA) for the treatment of complicated intra-abdominal and urinary tract infections, and has activity against carbapenem-resistant Enterobacteri...
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