ARTICLES|ONLINE FIRST Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial Luis Eduardo López-Cortés, Mercedes Delgado-Valverde, Elisa Moreno-Mellado, et al Lancet Infect Dis Published: January 09, 2024 DOI: https://doi.org/10.1016/S1473-3099(23)00686-2 Summary Background De-escalation from broad-spectrum to narrow-spe...

ARTICLES|ONLINE FIRST Individualised, short-course antibiotic treatment versus usual long-course treatment for ventilator-associated pneumonia (REGARD-VAP): a multicentre, individually randomised, open-label, non-inferiority trial Yin Mo, Suchart Booraphun, Andrew Yunkai Li, et al Lancet Respir Med Published: January 22, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00418-6 Summary Background Ventilator-associated pneumonia (VAP) is associated with ...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Seven Myths of Mechanical Ventilation in Paediatric and Neonatal Patients In this article, we will examine clinical concepts that have persisted over time, despite advancements in our understanding of physiology and technological innovations that have demonstrated their inapplicability in the routine clinical care of paediatric patients requiring respiratory support. These enduring beliefs have effectivel...

Research Letter  December 28, 2023 Lifting of Embargoes to Data Sharing in Clinical Trials Published in Top Medical Journals Maximilian Siebert, John P. A. Ioannidis JAMA. 2024;331(4):354-355. doi:10.1001/jama.2023.25394 Data sharing in clinical trials enhances trust and reproducibility and allows secondary analyses.1 However, sharing of clinical trials data is the exception rather than the rule2 and is often limited by embargoes, which const...

ARTICLES|ONLINE FIRST Risk factors for COVID-19-associated pulmonary aspergillosis: a systematic review and meta-analysis Francesca Gioia, Laura N Walti, Ani Orchanian-Cheff, et al Lancet Published: January 04, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00408-3 Summary Background COVID-19-associated pulmonary aspergillosis (CAPA) has been reported to be an emerging and potentially fatal complication of severe COVID-19. However, risk factors for C...

ARTICLES|ONLINE FIRST The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia Martí Català, Núria Mercadé-Besora, Raivo Kolde, et al Lancet Published: January 11, 2024 DOI:https://doi.org/10.1016/S2213-2600(23)00414-9 Summary Background Although vaccines have proved effective to prevent severe COVID-19, their effect on preventing long-term symptoms is not yet fully understoo...

ARTICLES|ONLINE FIRST Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial Claire Dahyot-Fizelier, Sigismond Lasocki, Thomas Kerforne, et al Lancet Respir Med Published: January 20, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00471-X Summary Background Patients with acute brain injury are at high risk of venti...

ARTICLES|ONLINE FIRST The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial Tinka Bakker, Joanna E Klopotowska, Dave A Dongelmans, et al Lancet Published:January 20, 2024 DOI:https://doi.org/10.1016/S0140-6736(23)02465-0 Summary Background Drug–drug interactions (DDIs) can harm patients admitted to the intensive ...

ORIGINAL ARTICLE Biomarker Changes during 20 Years Preceding Alzheimer’s Disease Jianping Jia, Yuye Ning, Meilin Chen, et al N Engl J Med 2024; 390:712-722DOI: 10.1056/NEJMoa2310168 Abstract BACKGROUND Biomarker changes that occur in the period between normal cognition and the diagnosis of sporadic Alzheimer’s disease have not been extensively investigated in longitudinal studies. METHODS We conducted a multicenter, nested case–control study of Alz...

ARTICLES| VOLUME 22, ISSUE 12, P1140-1149, DECEMBER 2023Download Full Issue Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials Rustam Al-Shahi Salman, Jacqueline Stephen, Prof Jayne F Tierney, et al. Lancet Neuron 2023; 22: 1140-1149 Published:October 12, 2023 DOI:https://doi.org/10.1016/S1474-4422(23)00315-0 Summar...