Original Investigation  Caring for the Critically Ill Patient March 19, 2024 Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults Kevin G. Buell, Alexandra B. Spicer, Jonathan D. Casey, et al JAMA. Published online March 19, 2024. doi:10.1001/jama.2024.2933 Key Points Question  Among critically ill adults, do the effects of peripheral oxygen-saturation (Spo2) targets on outcomes d...

Original Investigation  Caring for the Critically Ill Patient March 19, 2024 Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial Frederik M. Nielsen, Thomas L. Klitgaard, Martin Siegemund, et al JAMA. Published online March 19, 2024. doi:10.1001/jama.2024.2934 Key Points Question  Does targeting a Pao2 of 60 mm Hg vs 90 mm Hg affect the number of days...

Original Investigation  Infectious Diseases January 2, 2024 Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections Drew W. Engers, Pranita D. Tamma, Suiyini Fiawoo, et al JAMA Netw Open. 2024;7(1):e2349864. doi:10.1001/jamanetworkopen.2023.49864 Key Points Question  What is the timeline of transition from intravenous (IV) to oral antibiotics among patients with gram-negative blo...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalVenous thromboembolism in critically ill adult patients with hematologic malignancy: a population-based cohort studyCarini F. C. et al. OPEN ACCESS ~ OriginalAcute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trialMeersch M. et al Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with deliriumBekker Mortensen C. et al. Phase-3 ...

Research Letter  Equity, Diversity, and Inclusion January 11, 2024 Characteristics of Medical School Deans and University Hospital Directors in Japan Takashi Watari, Ashwin Gupta, Maika Hayashi, et al JAMA Netw Open. 2024;7(1):e2351526. doi:10.1001/jamanetworkopen.2023.51526 Introduction Medical school deans and university hospital directors are pivotal high-ranking leaders in health care organizations, exerting profound influence on th...

Original Investigation  Health Policy January 12, 2024 Vacation Days Taken, Work During Vacation, and Burnout Among US Physicians Christine A. Sinsky, Mickey T. Trockel, Lotte N. Dyrbye, et al JAMA Netw Open. 2024;7(1):e2351635. doi:10.1001/jamanetworkopen.2023.51635 Key Points Question  Are vacation days taken and working while on vacation associated with physician burnout? Findings  In this cross-sectional study...

Research Special Paper Publishers’ and journals’ instructions to authors on use of generative artificial intelligence in academic and scientific publishing: bibliometric analysis Conner Ganjavi, Michael B Eppler, Asli Pekcan, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077192 (Published 31 January 2024)Cite this as: BMJ 2024;384:e077192 Abstract Objectives To determine the extent and content of...

Research Letter  Pediatrics February 2, 2024 Interpretation of Antibiotic Trials in Pediatric Pneumonia Susan C. Lipsett, Alexander W. Hirsch, Richard G. Bachur, et al JAMA Netw Open. 2024;7(2):e2354470. doi:10.1001/jamanetworkopen.2023.54470 Introduction Recent randomized clinical trials have compared antibiotic regimens of varying intensity for the treatment of pediatric community-acquired pneumonia (CAP).1-4 These trials identif...

Original Investigation  Pediatrics February 2, 2024 Whole-Blood Gene Expression Profile After Hypoxic-Ischemic Encephalopathy Paolo Montaldo, Constance Burgod, Jethro A. Herberg, et al JAMA Netw Open. 2024;7(2):e2354433. doi:10.1001/jamanetworkopen.2023.54433 Key Points Question  Do genome expression profiles at birth in neonates with hypoxic-ischemic encephalopathy (HIE) in a high-income country (HIC) differ from those of the...

Original Investigation  Infectious Diseases March 13, 2024 COVID-19 Rebound After VV116 vs Nirmatrelvir-Ritonavir Treatment: A Randomized Clinical Trial Zhitao Yang, Yu Xu, Ruizhi Zheng, et al JAMA Netw Open. 2024;7(3):e241765. doi:10.1001/jamanetworkopen.2024.1765 Key Points Question  How common is COVID-19 rebound after a standard 5-day course of treatment with VV116 vs nirmatrelvir-ritonavir? Findings  In this ...