Medical News & Perspectives  January 12, 2024 As COVID-19 Cases Surge, Here’s What to Know About JN.1, the Latest SARS-CoV-2 “Variant of Interest” Rita Rubin JAMA. Published online January 12, 2024. doi:10.1001/jama.2023.27841 Parents often bask in the glow of their children’s accomplishments, so if SARS-CoV-2 variants were like people, BA.2.86 would be busting its buttons right about now. BA.2.86’s spawn, JN.1, has become the domi...

Original Investigation  January 8, 2024 Diagnostic Errors in Hospitalized Adults Who Died or Were Transferred to Intensive Care Andrew D. Auerbach, Tiffany M. Lee, Colin C. Hubbard, et al JAMA Intern Med. Published online January 8, 2024. doi:10.1001/jamainternmed.2023.7347 Key Points Question  How often do diagnostic errors happen in adult patients who are transferred to the intensive care unit (ICU) or die in the hospital, what...

Original Investigation  June 12, 2023 Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza: A Systematic Review and Meta-Analysis Ryan Hanula, Émilie Bortolussi-Courval, Arielle Mendel, et al JAMA Intern Med. 2024;184(1):18-27. doi:10.1001/jamainternmed.2023.0699 Key Points Question  Is the administration of oseltamivir to adult and adolescent outpatients with confirmed influenza associated with a reduced...

ARTICLES| VOLUME 12, ISSUE 1, E45-E54, JANUARY 2024 Oral swabs with a rapid molecular diagnostic test for pulmonary tuberculosis in adults and children: a systematic review E Chandler Church, Karen R Steingart, Gerard A Cangelosi, et al Lancet Global Health 2024; 12: E45-E54 Published:January, 2024 DOI: https://doi.org/10.1016/S2214-109X(23)00469-2 Summary Background Tuberculosis is a leading cause of infectious disease mortality worldwide, but diagno...

Inflammatory subphenotypes in patients at risk of ARDS: evidence from the LIPS-A trial Redaelli, S., von Wedel, D., Fosset, M. et al Intensive Care Med 49, 1499–1507 (2023). https://doi.org/10.1007/s00134-023-07244-z Abstract Purpose Latent class analysis (LCA) has identified hyper- and non-hyper-inflammatory subphenotypes in patients with acute respiratory distress syndrome (ARDS). It is unknown how early inflammatory subphenotypes can be identified in pat...

ARTICLES| VOLUME 6, ISSUE 1, E44-E57, JANUARY 2024Download Full Issue Development and validation of open-source deep neural networks for comprehensive chest x-ray reading: a retrospective, multicentre study Yashin Dicente Cid, Matthew Macpherson, Louise Gervais-Andre, et al Lancet Digital Health 2024; 6: E44-E57 Published:December 08, 2023 DOI: https://doi.org/10.1016/S2589-7500(23)00218-2 Summary Background Artificial intelligence (AI...

Association of language concordance and restraint use in adults receiving mechanical ventilation Gershengorn, H.B., Patel, S., Mallow, C.M. et al Intensive Care Med 49, 1489–1498 (2023) https://doi.org/10.1007/s00134-023-07243-0 Abstract Purpose Clinician–patient language concordance improves patient outcomes in non-intensive care unit (ICU) settings. We sought to assess the association of ICU nurse–patient language concordance with delirium-related outc...

Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study Zarbock, A., Weiss, R., Albert, F. et al. Intensive Care Med 49, 1441–1455 (2023) https://doi.org/10.1007/s00134-023-07169-7 Abstract Purpose The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries and health care systems is u...

Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial Obling, L.E.R., Beske, R.P., Meyer, M.A.S. et al. Intensive Care Med 2023; 49: 1467–1478 Abstract Purpose Patients who are successfully resuscitated following out-of-hospital cardiac arrest (OHCA) are still at a high risk of neurological damage and death. Inflammation and brain injury are components of the post-cardiac arr...

High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial Raffaele Di Fenza,  Naman S. Shetty,  Stefano Gianni, et al Am J Respir Crit Care Med 2023; 208: 1293-1304 Abstract Rationale: The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown. Objectives: The primary outcome was the change in arterial oxygenation (PaO2...