Original Investigation  Statistics and Research Methods Sex and All-Cause Mortality in the US, 1999 to 2019 Julia Francis, Barry I. Graubard, Hormuzd Katki, et al JAMA Netw Open 2026;9;(1):e2556299. doi:10.1001/jamanetworkopen.2025.56299 Key Points Question  Are there differences in mortality rates between males and females for all-cause mortality and the leading 9 causes of mortality? Findings &n...

Articles Medical oxygen and respiratory support requirements for patients hospitalised with COVID-19 in 23 low-income and middle-income countries: a prospective, observational cohort study Pryanka Relan, Jamie Rylance, Yaseen M Arabi, et al Lancet Global Health 2026; 14; e233-e241 Summary Background The COVID-19 pandemic highlighted a global shortage of, and inequity of access to, medical oxygen. Understanding patient outcomes an...

Articles Trends in mortality due to haemophagocytic lymphohistiocytosis across 29 European countries from 2011 to 2021: a retrospective, international, population-based study Leher Gumber, Reza Omidvar, Francesca Gonnelli, et al Lancet Rheumatol 2026; 8: e108-e115 https://doi.org/10.1016/S2665-9913(25)00292-9 Summary Background Previous research has suggested that the incidence of haemophagocytic lymphohistiocytosis is increasing in Europe. We aimed t...

Articles Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Lower Respiratory Infections and Antimicrobial Resistance Collaborators Lancet Infect Dis Available online 15 December 2025 https://doi.org/10.1016/S1473-3099(25)00689-9 Summary Background Lower respiratory infections (LRIs) remain the world's leading infectious cause of death. This analysis from...

Articles Cefiderocol versus standard therapy for hospital-acquired and health-care-associated Gram-negative bacterial bloodstream infection (the GAME CHANGER trial): an open-label, parallel-group, randomised trial David L Paterson, Helmi Sulaiman, Po-Yu Liu, et al Lancet Infect Dis 2026; 26: 148-159 https://doi.org/10.1016/S1473-3099(25)00469-4 Summary Background Bloodstream infections caused by bacteria with carbapenem resistance are associated with ...

Articles Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial Yao Lu, Ling Guan, Jialing Wu, et al Lancet Available online 30 January 2026 https://doi.org/10.1016/S0140-6736(25)01862-8 Summary Background Minocycline has been reported as a multi-target anti-neuroinflammatory drug with potential benefits for ischaemic stroke in preclinical models and small-scale c...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original Sex, time, and disability status differences in mortality, multidimensional morbidity, and health care utilization: a secondary analysis of the Canadian RECOVER studyBurns, K.E.A., Huszti, E., Li, Q. et al. EditorialUpdate on infection: from prevention to diagnosis and managementNseir, S., Salluh, J.I.F. & Póvoa, P. Update on sepsis and septic shock: from bundles to precision medicinePlata-Menchaca, E....

Research Letter  AI in Medicine Self-Disclosed Use of AI in Research Submissions to BMJ Journals Isamme AlFayyad, Maurice P. Zeegers, Lex Bouter, et al JAMA Published Online: January 28, 2026 doi: 10.1001/jama.2025.25688 Artificial intelligence (AI), including generative AI, has rapidly emerged as a powerful tool in scientific research and publication.1 Current estimates of AI use rely on self-reported su...

Research Letter  AI in Medicine Author Disclosure of Use of AI in Submissions to 13 JAMA Network Journals Roy H. Perlis, Annette Flanagin, Jacob Kendall-Taylor, et al JAMA Published Online: January 28, 2026 doi: 10.1001/jama.2025.25300 The scientific community has not reached consensus about the appropriate application of artificial intelligence (AI) in manuscript preparation and review.1 In August 2023, JAMA ...

Original Investigation  US State-Level Prevalence of Adult Obesity by Race and Ethnicity From 1990 to 2022 and Forecasted to 2035 Nicole K. DeCleene, Ethan Kahn, Chun-Wei Yuan, et al JAMA Published Online: January 28, 2026 doi: 10.1001/jama.2025.26817 Key Points Question  What are the current and future estimates of obesity prevalence in the US by state, race and ethnicity group, sex, and age? ...