Research Letter  Occupational Health Disinfecting Wipes and Barrier Resistance of Protective Clothing F. Selcen Kilinc-Balci, Patrick L. Yorio, Zafer Kahveci, et al JAMA Netw Open 2025;8;(10):e2539307. doi:10.1001/jamanetworkopen.2025.39307 Introduction Protective clothing (PC), including gowns and coveralls, is crucial personal protective equipment (PPE) for health care and laboratory workers (HCLWs) to prevent transmission of contaminated fluids. ...

Original Investigation  Targeted Oxygen for Initial Resuscitation of Preterm Infants: The TORPIDO 30/60 Randomized Clinical Trial Ju Lee Oei, Adrienne Kirby, Javeed Travadi, et al JAMA Published Online: December 10, 2025 doi: 10.1001/jama.2025.23327 Key Points Question  Does initiating resuscitation of extremely preterm newborns with a higher level of fraction of inspired oxygen (Fio2; 0.6) redu...

Original Investigation  Cardiology Light Exposure at Night and Cardiovascular Disease Incidence Daniel P. Windred, Angus C. Burns, Martin K. Rutter, et al JAMA Netw Open 2025;8;(10):e2539031. doi:10.1001/jamanetworkopen.2025.39031 Key Points Question  Is personal light exposure at night associated with cardiovascular disease incidence? Findings  In this cohort study of 88 905 adults aged older than 40 years, exposure to bright...

Articles Prognostic accuracy of clinical markers of postpartum bleeding in predicting maternal mortality or severe morbidity: a WHO individual participant data meta-analysis Ioannis Gallos, Caitlin R Williams, Malcolm J Price, et al Lancet 2025; 406: 1969-1982 https://doi.org/10.1016/S0140-6736(25)01639-3 Summary Background Postpartum haemorrhage (excessive bleeding after birth) is a leading cause of maternal mortality and morbidity worldwide. However...

Original Investigation  Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial Kristin A. Shimano, Amanda B. Grimes, Shipra Kaicker, et al JAMA Published Online: October 22, 2025 doi: 10.1001/jama.2025.18168 Key Points Question  What is the efficacy of eltrombopag compared with standard therapy in children with newly diagnosed i...

Articles Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa): a prospective, open-label, multicentre, non-inferiority, randomised clinical trial Charles Burdet, Nadia Saïdani, Céline Dupieux, et al Lancet Available online 17 October 2025 https://doi.org/10.1016/S0140-6736(25)01624-1 Summary Background Although widely used, cefazolin efficacy for the treatment of meticillin-susceptible Staphylococcus...

Research Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial Parco M Siu, Danny J Yu, Angus P Yu, et al BMJ 2025; 391 doi: https://doi.org/10.1136/bmj-2025-084320 (Published 26 November 2025)Cite this as: BMJ 2025;391:e084320 Abstract Objective To assess whether tai chi is non-inferior to cognitive behavioural therapy for insomnia (CBT-I), the first line treatment, for managin...

Original Investigation  Hematology Cost-Effectiveness of Cryopreserved vs Liquid-Stored Platelets for Managing Surgical Bleeding Zhomart Orman, Michael C. Reade, Denese C. Marks, et al JAMA Netw Open 2025;8;(12):e2554363. doi:10.1001/jamanetworkopen.2025.54363 Key Points Question  Are cryopreserved platelets cost-effective compared with liquid-stored platelets for managing active bleeding in patients unde...

Original Investigation  Rituximab for Relapsing Nephrotic Syndrome in Adults: A Randomized Clinical Trial Yoshitaka Isaka, Yusuke Sakaguchi, Maki Shinzawa, et al JAMA 2025;334;(22):2011-2019. doi:10.1001/jama.2025.19316 Key Points Question  Does rituximab, compared with placebo, prevent relapse in adult patients with frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome? Findings&n...

Original Investigation  Gastroenterology and Hepatology Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis: A Randomized Clinical Trial Wenhua He, Ling Ding, Zhijun Liu, et al JAMA Netw Open 2025;8;(11):e2542124. doi:10.1001/jamanetworkopen.2025.42124 Key Points Question  Is low-molecular-weight heparin combined with insulin superior to insulin alone in improving clinical...