ORIGINAL ARTICLE Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage Gustavo Pradilla, Jonathan J. Ratcliff, Alex J. Hall, et al N Engl J Med 2024;390:1277-1289 DOI: 10.1056/NEJMoa2308440 Abstract BACKGROUND Trials of surgical evacuation of supratentorial intracerebral hemorrhages have generally shown no functional benefit. Whether early minimally invasive surgical removal would result in better outcomes than medical management is no...

ORIGINAL ARTICLE Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock Jacob E. Møller, Thomas Engstrøm, Lisette O. Jensen, et al N Engl J Med Published April 7, 2024 DOI: 10.1056/NEJMoa2312572 Abstract BACKGROUND The effects of temporary mechanical circulatory support with a microaxial flow pump on mortality among patients with ST-segment elevation myocardial infarction (STEMI) complicated by ca...

ORIGINAL ARTICLE Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy Martin S. Maron, Ahmad Masri, Michael E. Nassif, et al N Engl J Med 2024;390:1849-1861 DOI: 10.1056/NEJMoa2401424 Abstract BACKGROUND One of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from left ventricular outflow tract obstruction. ...

Original Investigation  Health Informatics March 20, 2024 Artificial Intelligence–Generated Draft Replies to Patient Inbox Messages Patricia Garcia, Stephen P. Ma, Shreya Shah, et al JAMA Netw Open. 2024;7(3):e243201. doi:10.1001/jamanetworkopen.2024.3201 Key Points Question  What is the adoption of and clinician experience with clinical practice deployment of a large language model used to draft responses to patient inbox mes...

Research Derivation and external validation of a simple risk score for predicting severe acute kidney injury after intravenous cisplatin: cohort study Shruti Gupta, Ilya G Glezerman, Jamie S Hirsch, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077169 (Published 27 March 2024)Cite this as: BMJ 2024;384:e077169 Abstract Objective To develop and externally validate a prediction model for severe cisplatin associated acute kidney injury (CP-AKI...

Research Delirium and incident dementia in hospital patients in New South Wales, Australia: retrospective cohort study Emily H Gordon, David D Ward, Hao Xiong, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077634 (Published 27 March 2024)Cite this as: BMJ 2024;384:e077634 Abstract Objectives To determine the strength and nature of the association between delirium and incident dementia in a population of older adult patients without dementia...

Original Investigation  Hematology March 26, 2024 Accuracy of Diagnosing Heparin-Induced Thrombocytopenia Emil List Larsen, Henning Nilius, Jan-Dirk Studt, et al JAMA Netw Open. 2024;7(3):e243786. doi:10.1001/jamanetworkopen.2024.3786 Key Points Question  Is the current diagnostic practice for suspected heparin-induced thrombocytopenia (HIT) accurate? Findings  In this diagnostic study of 1318 patients suspected o...

Original Investigation  Infectious Diseases March 27, 2024 CDC’s Hospital-Onset Clostridioides difficile Prevention Framework in a Regional Hospital Network Nicholas A. Turner, Jay Krishnan, Alicia Nelson, et al JAMA Netw Open. 2024;7(3):e243846. doi:10.1001/jamanetworkopen.2024.3846 Key Points Question  Was implementation of the Centers for Disease Control and Prevention’s Strategies to Prevent Clostridioides d...

Original Investigation  April 1, 2024 Reducing Hospitalizations and Multidrug-Resistant Organisms via Regional Decolonization in Hospitals and Nursing Homes Gabrielle M. Gussin, James A. McKinnell, Raveena D. Singh, et al JAMA. Published online April 1, 2024. doi:10.1001/jama.2024.2759 Key Points Question  Is implementation of a regional hospital and nursing home decolonization collaborative (coordinated intervention adopted by p...

Original Investigation  March 18, 2024 Text vs Patient Portal Messaging to Improve Influenza Vaccination Coverage: A Health System–Wide Randomized Clinical Trial Peter G. Szilagyi, O. Kenrik Duru, Alejandra Casillas, et al JAMA Intern Med. Published online March 18, 2024. doi:10.1001/jamainternmed.2024.0001 Key Points Question  Can either patient portal or text message reminders to patients abou...