Original Investigation  February 14, 2024 Implementation of Best Practices in Pancreatic Cancer Care in the Netherlands: A Stepped-Wedge Randomized Clinical Trial Tara M. Mackay, Anouk E. J. Latenstein, Simone Augustinus, et al JAMA Surg. Published online February 14, 2024. doi:10.1001/jamasurg.2023.7872 Key Points Question  Can enhanced nationwide implementation of guideline-based best practice...

Research Letter  February 15, 2024 Prevalence of Immunosuppression Among US Adults Melissa L. Martinson, Jessica Lapham JAMA. Published online February 15, 2024. doi:10.1001/jama.2023.28019 The prevalence of immunosuppression from health conditions and medication use among US adults is often reported to be about 3%, which is based on an estimate of 2.7% from nationally representative data1 from 2013 and an estimate of 2.8% for the preval...

RESEARCH ARTICLE VOLUME 20, 100270, MARCH 2020 Clinical risk assessment model to predict venous thromboembolism risk after immobilization for lower-limb trauma Banne Nemeth, Delphine Douillet, Saskia le Cessie, et al EClinicalMedicine 2020; 20: 100270 Published: February 04, 2020 DOI: https://doi.org/10.1016/j.eclinm.2020.100270 Abstract Background Patients with lower-limb trauma requiring immobilization have an increased risk of venous thromboembolis...

ARTICLES|ONLINE FIRST Targeted prophylactic anticoagulation based on the TRiP(cast) score in patients with lower limb immobilisation: a multicentre, stepped wedge, randomised implementation trial Delphine Douillet, Andrea Penaloza, Damien Viglino, et al Lancet Published: February 15, 2024 DOI:https://doi.org/10.1016/S0140-6736(23)02369-3 Summary Background Prophylactic anticoagulation in emergency department patients with lower limb trauma requiring i...

ARTICLES|ONLINE FIRST Solar-powered O2 delivery for the treatment of children with hypoxaemia in Uganda: a stepped-wedge, cluster randomised controlled trial Nicholas Conradi, Robert O Opoka, Qaasim Mian, et al Lancet Published: February 14, 2024 DOI:https://doi.org/10.1016/S0140-6736(23)02502-3 Summary Background Supplemental O2 is not always available at health facilities in low-income and middle-income countries (LMICs). Solar-powered O2delive...

ARTICLES|ONLINE FIRST Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data Xin Wang, You Li, Ting Shi, et al Lancet Published: February 14, 2024 DOI:https://doi.org/10.1016/S0140-6736(24)00138-7 Summary Background Infants and young children born prematurely ...

Original Investigation  February 13, 2024 Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates Kevin C. Zhang, Nikhil Narang, Carine Jasseron, et al JAMA. 2024;331(6):500-509. doi:10.1001/jama.2023.27029 Key Points Question  Which medical urgency system identifies the adult US heart transplant candidates most likely to die without heart transplant? Findings &n...

ORIGINAL ARTICLE Cefepime–Taniborbactam in Complicated Urinary Tract Infection Florian M. Wagenlehner, Leanne B. Gasink, Paul C. McGovern, et al N Engl J Med 2024; 390:611-622DOI: 10.1056/NEJMoa2304748 Abstract BACKGROUND Carbapenem-resistant Enterobacterales species and multidrug-resistant Pseudomonas aeruginosaare global health threats. Cefepime–taniborbactam is an investigational β-lactam and β-lactamase inhibitor combination with activity agains...

Original Investigation  February 13, 2024 Mass Azithromycin Distribution to Prevent Child Mortality in Burkina Faso: The CHAT Randomized Clinical Trial Catherine E. Oldenburg, Mamadou Ouattara, Mamadou Bountogo, et al JAMA. 2024;331(6):482-490. doi:10.1001/jama.2023.27393 Key Points Question  Does twice-annual mass azithromycin distribution prevent all-cause childhood mortality among children in Burkina Faso aged 1 to 59 months i...

Research Duration of cardiopulmonary resuscitation and outcomes for adults with in-hospital cardiac arrest: retrospective cohort study Masashi Okubo, Sho Komukai, Lars W Andersen, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-076019 (Published 07 February 2024)Cite this as: BMJ 2024;384:e076019 Abstract Objective To quantify time dependent probabilities of outcomes in patients after in-hospital cardiac arrest as a function of duration of ca...