Original Investigation January 24, 2022 Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial Gavin D. Perkins, Chen Ji, Bronwen A. Connolly, et al JAMA. Published online January 24, 2022. doi:10.1001/jama.2022.0028 Key Points Question  What is the effect of initial noni...

ORIGINAL ARTICLEFREE PREVIEW Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia Kristi L. Watterberg, Michele C. Walsh, Lei Li, et al N Engl J Med 2022; 386:1121-1131DOI: 10.1056/NEJMoa2114897 Abstract BACKGROUND Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment after the second postnatal...

Original Investigation Caring for the Critically Ill PatientJanuary 24, 2022 Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19 Hidde Heesakkers, Johannes G. van der Hoeven, Stijn Corsten, et al JAMA. Published online January 24, 2022. doi:10.1001/jama.2022.0040 Key Points Question  What are the 1-year outcomes among patients who survive intensive care unit (ICU) treatment for ...

ORIGINAL ARTICLE Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar Laith J. Abu-Raddad, Hiam Chemaitelly, Houssein H. Ayoub, et al N Engl J Med March 9, 2022DOI: 10.1056/NEJMoa2200797 Abstract BACKGROUND Waning of vaccine protection against coronavirus disease 2019 (Covid-19) and the emergence of the omicron (or B.1.1.529) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to expedited efforts...

ARTICLES|ONLINE FIRST Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis COVID-19 Forecasting Team Lancet Published: February 24, 2022 DOI:https://doi.org/10.1016/S0140-6736(21)02867-1 Summary Background The infection–fatality ratio (IFR) is a metric that quantifies the likelihood of an individual dying once infected with a pathogen. Understanding the determinants of IFR var...

Original Investigation January 21, 2022 Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants Emma K. Accorsi, Amadea Britton, Katherine E. Fleming-Dutra, et al JAMA. Published online January 21, 2022. doi:10.1001/jama.2022.0470 Key Points Question  What is the association between 3 doses of mRNA COVID-19 vaccine and symptomatic SARS-CoV-2 infection with th...

ARTICLES| VOLUME 399, ISSUE 10322, P384-392, JANUARY 22, 2022 An educational programme in neonatal intensive care units (SEPREVEN): a stepped-wedge, cluster-randomised controlled trial Laurence Caeymaex, Dominique Astruc, Valérie Biran, et al Lancet Published:January 22, 2022DOI:https://doi.org/10.1016/S0140-6736(21)01899-7 Summary Background Patients in neonatal intensive care units (NICUs) are at high risk of adverse events. The effects ...

Research Letter January 28, 2022 Frequency and Risk of Emergency Medical Service Interhospital Transportation of Patients With Acute Lower Respiratory Tract Illness During the COVID-19 Pandemic in the US Sadia H. Sarzynski, Alex Mancera, Clay Mann, et al JAMA. 2022;327(9):874-877. doi:10.1001/jama.2022.0812 Surges in hospital COVID-19 caseloads are detrimental to patients hospitalized with COVID-191 and other conditions.2 Transporting patients out of hosp...

ARTICLES|ONLINE FIRST A three-step support strategy for relatives of patients dying in the intensive care unit: a cluster randomised trial Nancy Kentish-Barnes, Sylvie Chevret, Sandrine Valade, et al Lancet Published:January 19, 2022DOI:https://doi.org/10.1016/S0140-6736(21)02176-0 Summary Background In relatives of patients dying in intensive care units (ICUs), inadequate team support can increase the prevalence of prolonged grief and other psychologica...

Research SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study Anders Husby, Jørgen Vinsløv Hansen, Emil Fosbøl, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-068665 (Published 16 December 2021)Cite this as: BMJ 2021;375:e068665 Abstract Objective To investigate the association between SARS-CoV-2 vaccination and myocarditis or myopericarditis. Design Population based cohort study. Setting D...