ARTICLES| VOLUME 5, ISSUE 4, E390-E399, APRIL 2024 Whole-genome characterisation of Escherichia coli isolates from patients with bacteraemia presenting with sepsis or septic shock in Spain: a multicentre cross-sectional study Natalia Maldonado, Inmaculada López-Hernández, Andrea García-Montaner, et al Lancet Microbe 2024; 5: E390-E399 DOI: https://doi.org/10.1016/S2666-5247(23)00369-5 Summary Background Escherichia coli is the most frequent cause...

Original Investigation  April 19, 2024 Stewardship Prompts to Improve Antibiotic Selection for Pneumonia: The INSPIRE Randomized Clinical Trial Shruti K. Gohil, Edward Septimus, Ken Kleinman, et al JAMA. Published online April 19, 2024. doi:10.1001/jama.2024.6248 Key Points Question  Can computerized provider order entry (CPOE) prompts that provide patient-specific risk estimates for multidrug-resistant organisms (MDROs) reduce e...

Original Investigation  Emergency Medicine April 19, 2024 Shifts in Diagnostic Testing for Headache in the Emergency Department, 2015 to 2021 Dustin G. Mark, Brandon H. Horton, Mary E. Reed, et al JAMA Netw Open. 2024;7(4):e247373. doi:10.1001/jamanetworkopen.2024.7373 Key Points Question  Has the diagnostic evaluation of headache in the emergency department recently changed? Findings  In a cohort study of 21 emer...

ARTICLES| VOLUME 24, ISSUE 4, P375-385, APRIL 2024 Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial Luis Eduardo López-Cortés, Mercedes Delgado-Valverde, Elisa Moreno-Mellado, et al Lancet Infect Dis 2024; 24: 375-385 DOI:https://doi.org/10.1016/S1473-3099(23)00686-2 Summary Background De-escalation from broad-spec...

Research Glucagon-like peptide 1 receptor agonist use and risk of thyroid cancer: Scandinavian cohort study Björn Pasternak, Viktor Wintzell, Anders Hviid, et al BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2023-078225 (Published 10 April 2024)Cite this as: BMJ 2024;385:e078225 Abstract Objective To investigate whether use of glucagon-like peptide 1 (GLP1) receptor agonists is associated with increased risk of thyroid cancer. Design Scandinav...

ORIGINAL ARTICLE Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke Gang Li, Yapeng Lin, Jie Yang, et al N Engl J Med 2024;390:1862-1872 DOI: 10.1056/NEJMoa2314741 Abstract BACKGROUND Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated acute stroke is ...

Original Investigation  Emergency Medicine April 9, 2024 Emergency Nurses’ Reasons for Not Recommending Their Hospital to Clinicians as a Good Place to Work K. Jane Muir, Raina M. Merchant, Karen B. Lasater, et al JAMA Netw Open. 2024;7(4):e244087. doi:10.1001/jamanetworkopen.2024.4087 Key Points Question  Why do emergency nurses not recommend their hospital to clinicians as a good place to work? Findings  This qu...

Original Investigation  April 10, 2024 Automated CT Analysis of Body Composition as a Frailty Biomarker in Abdominal Surgery Ijeamaka Anyene Fumagalli, Sidney T. Le, Peter D. Peng, et al JAMA Surg. Published online April 10, 2024. doi:10.1001/jamasurg.2024.0628 Key Points Question  Can preoperative computed tomography (CT) scans provide patient frailty assessments that are associated with outcomes of abdominal surgery? Finding...

Research Letter  April 8, 2024 Cardiac Function Before Sepsis and Clinical Outcomes Stuthi Iyer, Jason N. Kennedy, Jacob C. Jentzer, et al JAMA. Published online April 8, 2024. doi:10.1001/jama.2024.3917 Between 2009 and 2014, 21% of US adults with sepsis did not survive.1 Guidelines recommend urgent resuscitation of patients with sepsis, although the ideal treatment regimen is not clear2 and challenges to resuscitation, including t...

Research Letter  April 10, 2024 Intravascular Microaxial Left Ventricular Assist Device Manufacturer Payments to Cardiologists and Use of Devices Sanket S. Dhruva, Joseph S. Ross, Michael A. Steinman, et al JAMA. Published online April 10, 2024. doi:10.1001/jama.2024.4682 Mechanical circulatory support devices are increasingly used by physicians for patients receiving percutaneous coronary intervention (PCI).1 Use of intra-aortic balloon...